Endogenous Opioid Regulation of Hippocampal Function

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system.

1934 • 1,982 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats

1985 • 1,101 citations

Lamellar organization of hippocampal excitatory pathways

1971 • 914 citations

Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity

1988 • 912 citations

A golgi study of cell types in the hilar region of the hippocampus in the rat

1978 • 889 citations

Activity-Dependent Action Potential Invasion and Calcium Influx into Hippocampal CA1 Dendrites

1995 • 846 citations

Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study

1994 • 840 citations

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

1989 • 815 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor

1982 • 777 citations

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

1993 • 736 citations

Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The “dormant basket cell” hypothesis and its possible relevance to temporal lobe epilepsy

1991 • 706 citations

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

1987 • 616 citations

Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission

1991 • 615 citations

Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy

1990 • 615 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Opioid Peptides May Excite Hippocampal Pyramidal Neurons by Inhibiting Adjacent Inhibitory Interneurons

1979 • 610 citations

Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP

1994 • 600 citations

Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones ¹

1989 • 552 citations

Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence

1991 • 539 citations

The current excitement in long term potentiation

1988 • 538 citations

Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists

1987 • 529 citations

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

1994 • 501 citations

Synaptic Activation of Voltage-Gated Channels in the Dendrites of Hippocampal Pyramidal Neurons

1995 • 449 citations

Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

1982 • 448 citations

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

1989 • 441 citations

Specific receptor for the opioid peptide dynorphin: structure--activity relationships.

1981 • 411 citations

Peptidergic transmission in sympathetic ganglia of the frog.

1982 • 387 citations

Electrophysiology of opioids.

1983 • 377 citations

Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate

1974 • 373 citations

Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats

1992 • 369 citations

Molecular biology of opioid receptors

1993 • 358 citations

Localization of enkephalin‐like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus

1981 • 357 citations

Atrial G protein-activated K+ channel: expression cloning and molecular properties.

1993 • 355 citations

The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation

1993 • 342 citations

Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin

1995 • 339 citations

Enkephalin blocks inhibitory pathways in the vertebrate CNS

1980 • 334 citations

Differential release of amino acids, neuropeptides, and catecholamines from isolated nerve terminals

1991 • 330 citations

Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors.

1988 • 315 citations

The development, ultrastructure and synaptic connections of the mossy cells of the dentate gyrus

1985 • 313 citations

Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.

1977 • 299 citations

The role of Ca2+ channels in hippocampal mossy fiber synaptic transmission and long-term potentiation

1994 • 297 citations

Enkephalin hyperpolarizes interneurones in the rat hippocampus.

1988 • 296 citations

Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity.

1983 • 289 citations

Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus

1993 • 279 citations

Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibers

1992 • 279 citations

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

1987 • 266 citations

The Opiate Receptors

1978 • 266 citations

On the potassium conductance increased by opioids in rat locus coeruleus neurones.

1985 • 265 citations

Enkephalin opens potassium channels on mammalian central neurones

1982 • 264 citations

Opioid inhibition of GABA release from presynaptic terminals of rat hippocampal interneurons

1992 • 261 citations

Frequency-Dependent Noradrenergic Modulation of Long-Term Potentiation in the Hippocampus

1984 • 257 citations

The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C

1995 • 245 citations

Nonopiate Effects of Dynorphin and Des-Tyr-Dynorphin

1982 • 235 citations

Isolation and structural organization of the human preproenkephalin gene

1982 • 217 citations

Mechanism of mu‐opioid receptor‐mediated presynaptic inhibition in the rat hippocampus in vitro.

1993 • 216 citations

Exocytosis from large dense cored vesicles outside the active synaptic zones of terminals within the trigeminal subnucleus caudalis: A possible mechanism for neuropeptide release

1986 • 216 citations

Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses

1992 • 201 citations

Coupling of opiate receptors to adenylate cyclase: requirement for Na+ and GTP.

1979 • 200 citations

Animal models of normal aging: Relationship between cognitive decline and markers in hippocampal circuitry

1993 • 195 citations

beta-Endorphin induces nonconvulsive limbic seizures.

1978 • 192 citations

A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra

1984 • 191 citations

Molecular cloning and amino acid sequence of rat enkephalinase

1987 • 190 citations

Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus

1990 • 187 citations

Ca2+ and secretory-vesicle dynamics

1995 • 185 citations

Distribution of opiate receptor subtypes and enkephalin and dynorphin immunoreactivity in the hippocampus of squirrel, guinea pig, rat, and hamster

1987 • 180 citations

Receptor‐mediated regulation of calcium channels and neurotransmitter release

1990 • 168 citations

Norepinephrine induces pathway-specific long-lasting potentiation and depression in the hippocampal dentate gyrus.

1989 • 168 citations

Differential regulation of neuropeptide and proto-oncogene mRNA content in the hippocampus following recurrent seizures

1987 • 168 citations

Opiate Antagonists Improve Spatial Memory

1983 • 162 citations

Opioid inhibition of Ih via adenylyl cyclase

1994 • 160 citations

Seizures induce dramatic and distinctly different changes in enkephalin, dynorphin, and CCK immunoreactivities in mouse hippocampal mossy fibers

1988 • 157 citations

Dynorphin A decreases voltage‐dependent calcium conductance of mouse dorsal root ganglion neurones.

1986 • 150 citations

Demonstration and Characterization of Opiate Inhibition of the Striatal Adenylate Cyclase

1981 • 149 citations

Muscarinic Depression of Long-Term Potentiation in CA3 Hippocampal Neurons

1988 • 146 citations

Induction of long-term potentiation at hippocampal mossy-fiber synapses follows a Hebbian rule

1990 • 145 citations

Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation

1991 • 145 citations

Opioid Actions on Membrane Ion Channels

1993 • 144 citations

Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters

1994 • 143 citations

Opioid receptors modulate diverse types of calcium channels in the nucleus tractus solitarius of the rat

1994 • 140 citations

Enkephalin and opiate narcotics increase cyclic GMP accumulation in slices of rat neostriatum

1976 • 132 citations

kappa-Opioid receptors also increase potassium conductance.

1993 • 131 citations

Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus

1985 • 131 citations

Morphine and opioid peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells in vitro without alteration of membrane potential.

1981 • 130 citations

Endogenous opioid peptides and epilepsy: quieting the seizing brain?

1988 • 126 citations

Behavioral effects and in vivo degradation of intraventricularly administered dynorphin-(1-13) and D-Ala2-dynorphin-(1-11) in rats

1980 • 125 citations

Long-term potentiation of hippocampal mossy fiber synapses is blocked by postsynaptic injection of calcium chelators

1989 • 125 citations

Selective Protection of Methionine Enkephalin Released from Brain Slices by Enkephalinase Inhibition

1981 • 123 citations

Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons

1994 • 123 citations

Norepinephrine regulates long-term potentiation of both the population spike and dendritic EPSP in hippocampal dentate gyrus

1987 • 119 citations

Delta and mu enkephalins inhibit spontaneous GABA-mediated IPSCs via a cyclic AMP-independent mechanism in the rat hippocampus

1995 • 119 citations

Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells

1994 • 117 citations

Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus

1992 • 116 citations

Regulation of endogenous acetylcholine release from mammalian brain slices by opiate receptors: Hippocampus, striatum and cerebral cortex of guinea-pig and rat

1989 • 115 citations

Morphological changes in the dentate gyrus in human temporal lobe epilepsy.

1992 • 114 citations

Kainic acid alters the metabolism of Met5-enkephalin and the level of dynorphin A in the rat hippocampus

1986 • 114 citations

Changes in dynorphin, enkephalin and cholecystokinin content of hippocampus and substantia nigra after amygdala kindling

1986 • 113 citations

Opioid receptor regulation of the release of norepinephrine in brain

1987 • 111 citations

Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes.

1995 • 110 citations

Changes of hippocampal Met-enkephalin content after recurrent motor seizures

1980 • 110 citations

Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task.

1989 • 110 citations

L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells

1995 • 109 citations

Neuroanatomical localization ofκ1and κ2 opioid receptors in rat and guinea pig brain

1991 • 108 citations

Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells.

1992 • 108 citations

Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor.

1994 • 105 citations

Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro

1994 • 104 citations

Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents.

1990 • 104 citations

κOpiate Agonists Inhibit Ca2+ Influx in Rat Spinal Cord-Dorsal Root Ganglion Cocultures

1989 • 104 citations

Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization

1992 • 103 citations

The epileptogenic spectrum of opiate agonists

1982 • 103 citations

Agonist-induced Desensitization of the Mu Opioid Receptor-coupled Potassium Channel (GIRK1)

1995 • 102 citations

Cholera toxin-A subunit blocks opioid excitatory effects of sensory neuron action potentials indicating mediation by Gs-linked opioid receptors

1990 • 102 citations

Large long-lasting potentiation in the dentate gyrus in vitro during blockade of inhibition

1983 • 101 citations

The ionic mechanisms underlying opioid actions

1988 • 101 citations

μ-, δ-, κ-Opioid receptors and their subtypes. A critical review with emphasis on radioligand binding experiments

1994 • 101 citations

Opioid receptor selectivity of dynorphin gene products.

1984 • 99 citations

Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras

1994 • 99 citations

A Chimeric Study of the Molecular Basis of Affinity and Selectivity of the κ and the δ Opioid Receptors.

1995 • 98 citations

Possible mechanisms of enkephalin action on hippocampal CA1 pyramidal neurons

1981 • 96 citations

Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus.

1988 • 94 citations

EPSPs of dentate gyrus granule cells during epileptiform bursts of dentate hilar "mossy" cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices

1994 • 93 citations

Rat hippocampus and memory for places of changing significance.

1978 • 92 citations

Epileptiform effects of met-enkephalin, β-endorphin and morphine: Kindling of generalized seizures and potentiation of epileptiform effects by handling

1985 • 91 citations

Characterization of the Rat Prodynorphin Gene

1989 • 90 citations

Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.

1995 • 90 citations

Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse.

1991 • 89 citations

Long‐term Potentiation and Field EPSPs in the Lateral and Medial Perforant Paths in the Dentate Gyrus In Vitro: a Comparison

1992 • 88 citations

Fast, local signal transduction between the mu opioid receptor and Ca2+ channels

1995 • 88 citations

Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.

1994 • 87 citations

Enkephalin biosynthesis and enkephalin gene expression are increased in hippocampal mossy fibers following a unilateral lesion of the hilus

1987 • 86 citations

Hippocampal circuitry complicates analysis of long‐term potentiation in mossy fiber synapses

1993 • 84 citations

Naloxone blocks the induction of long-term potentiation in the lateral but not in the medial perforant pathway in the anesthetized rat

1988 • 84 citations

Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells

1994 • 82 citations

U50,488, a highly selective kappa opioid: anticonvulsant profile in rats.

1986 • 82 citations

Dynorphin- and enkephalin-like immunoreactivity is altered in limbic-basal ganglia regions of rat brain after repeated electroconvulsive shock.

1986 • 82 citations

U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals

1991 • 81 citations

μ-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening

1995 • 81 citations

Opioid receptors are involved in an NMDA receptor-independent mechanism of LTP induction at hippocampal mossy fiber-CA3 synapses

1991 • 81 citations

Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus.

1994 • 80 citations

Systemic administration of kainic acid differentially regulates the levels of prodynorphin and proenkephalin mRNA and peptides in the rat hippocampus

1991 • 78 citations

δ Opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo

1991 • 77 citations

Forskolin and Phorbol Esters Reduce the Same Potassium Conductance of Mouse Neurons in Culture

1987 • 77 citations

Characterization and Distribution of a Cloned Rat μ‐Opioid Receptor

1995 • 76 citations

Mu opioid receptors are associated with the induction of hippocampal mossy fiber long-term potentiation.

1992 • 75 citations

Focal Stimulation of the Mossy Fibers Releases Endogenous Dynorphins That Bind _K1‐Opioid Receptors in Guinea Pig Hippocampus

1991 • 75 citations

Dynorphin- and enkephalin-like immunoreactivity is altered in limbic- basal ganglia regions of rat brain after repeated electroconvulsive shock

1986 • 75 citations

Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus.

1983 • 74 citations

Nimodipine improves spatial working memory and elevates hippocampal acetylcholine in young rats

1991 • 74 citations

Amygdaloid kindling increases enkephalin-like immunoreactivity but decreases dynorphin-A-like immunoreactivity in rat hippocampus

1986 • 74 citations

Microinjection of dynorphin into the hippocampus impairs spatial learning in rats

1990 • 73 citations

Functional Couplings of the δ- and the κ-Opioid Receptors with the G-Protein-Activated K+ Channel

1995 • 73 citations

Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus

1994 • 70 citations

Excessive intra- and supragranular mossy fibers in the dentate gyrus of tottering (tg/tg) mice

1989 • 69 citations

Effects of opiate antagonists on spatial memory in young and aged rats

1985 • 69 citations

Characterization of Opioid Receptors Modulating Noradrenaline Release in the Hippocampus of the Rabbit

1986 • 69 citations

Inhibition of Ca2+ currents by a mu-opioid in a defined subset of rat sensory neurons

1993 • 69 citations

Effects of enkephalin, morphine, and naloxone on the electrical activity of the in vitro hippocampal slice preparation

1981 • 69 citations

Anticonvulsant action of acute morphine administration in rats.

1976 • 67 citations

Kainate‐Induced Changes in Opioid Peptide Genes and AP‐1 Protein Expression in the Rat Hippocampus

1993 • 67 citations

Topographically selective reinnervation of adult mammalian skeletal muscles

1988 • 67 citations

Molecular and cellular mechanisms of neurotransmitter release

1994 • 67 citations

Activation of AP5-sensitive NMDA Receptors is Not Required to Induce LTP of Synaptic Transmission in the Lateral Perforant Path

1991 • 67 citations

Opioid receptor activation is one factor underlying the frequency dependence of mossy fiber LTP induction

1994 • 65 citations

Bimodal Opioid Regulation of Cyclic AMP Formation: Implications for Positive and Negative Coupling of Opiate Receptors to Adenylyl Cyclase

1994 • 65 citations

On the relationship between neuropathology and pathophysiology in the epileptic hippocampus of humans and experimental animals

1994 • 65 citations

Enkephalin inhibition of inhibitory input to CA1 and CA3 pyramidal neurons in the hippocampus

1982 • 65 citations

Rapid kindling with recurrent hippocampal seizures

1993 • 64 citations

Immunocytochemical localization of delta opioid receptors in mouse brain

1995 • 64 citations

Relationship between hippocampal opioid peptides and seizures

1993 • 63 citations

The k-opiate agonist U50488H decreases the entry of 45Ca into rat cortical synaptosomes by inhibiting N- but not L-type calcium channels

1990 • 63 citations

The hippocampus: A biological model for studying learning and memory

1994 • 62 citations

Naloxone and long term potentiation of hippocampal CA3 field potentials in vitro

1983 • 60 citations

Dissociation of μ and δ opioid receptor-mediated reductions in evoked and spontaneous synaptic inhibition in the rat hippocampus in vitro

1992 • 59 citations

Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain

1989 • 59 citations

Separable roles of hippocampal granule cells in forgetting and pyramidal cells in remembering spatial information

1987 • 58 citations

Modification of kindled amygdaloid seizures by opiate agonists and antagonists.

1984 • 58 citations

Presynaptic K‐Opioid Receptors on Noradrenergic Nerve Terminals Couple to G Proteins and Interact with the α₂‐Adrenoceptors

1989 • 56 citations

Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat

1985 • 56 citations

Effects of met-enkephalin on GABAergic spontaneous miniature IPSPs in organotypic slice cultures of the rat hippocampus

1993 • 55 citations

Inhibition of glutamate release by presynaptic kappa 1-opioid receptors in the guinea pig dentate gyrus

1994 • 54 citations

Selective impairment of declarative memory following stimulation of dentate gyrus granule cells: a naloxone-sensitive effect

1984 • 54 citations

Opioid peptide modulation of Ca2+-dependent K+ and voltage-activated Ca2+ currents in bovine adrenal chromaffin cells

1993 • 52 citations

Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus

1990 • 52 citations

Levels of prodynorphin mRNA in rat dentate gyrus are decreased during hippocampal kindling

1987 • 51 citations

Selective kappa antagonist properties of nor-binaltorphimine in the rat mes seizure model

1989 • 51 citations

Opiate-induced seizures: A study of μ and δ specific mechanisms

1986 • 51 citations

The Posttranslational Processing of Prodynorphin in the Rat Anterior Pituitary*

1989 • 50 citations

Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the rat

1984 • 50 citations

cellular responses to electrophoretically applied dynorphin in the rat hippocampus

1982 • 49 citations

An in vitro autoradiographic analysis of mu and delta opioid binding in the hippocampal formation of kindled rats

1987 • 49 citations

K‐Opioid Agonist Modulation of [³H]Thymidine Incorporation into DNA: Evidence for the Involvement of Pertussis Toxin‐Sensitive G Protein‐Coupled Phosphoinositide Turnover

1993 • 49 citations

Vesicle-associated Membrane Protein (VAMP)/Synaptobrevin-2 Is Associated with Dense Core Secretory Granules in PC12 Neuroendocrine Cells

1995 • 49 citations

Opiate-like electroencephalographic and behavioral effects of electroconvulsive shock in rats

1981 • 49 citations

F11 neuroblastoma × DRG neuron hybrid cells express inhibitory μ- and δ-opioid receptors which increase voltage-dependent K+ currents upon activation

1992 • 49 citations

Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-A and -B may act on μ-receptors in the CA1 region

1985 • 47 citations

Opioid actions at mu and delta receptors in the rat dentate gyrus in vitro.

1993 • 47 citations

Colocalization of mu opioid receptors with GIRK1 potassium channels in the rat brain: an immunocytochemical study.

1995 • 47 citations

Pro- and anticonvulsant action of morphine in rats

1980 • 47 citations

Induction of the Rat Prodynorphin Gene through Gs-Coupled Receptors May Involve Phosphorylation-Dependent Derepression and Activation

1994 • 45 citations

Frequency-dependent associative long-term potentiation at the hippocampal mossy fiber-CA3 synapse.

1994 • 44 citations

Opiate modification of amygdaloid-kindled seizures in rats

1982 • 44 citations

The anticonvulsant effect of opioids and opioid peptides against maximal electroshock seizures in rats

1984 • 43 citations

Repeated electroconvulsive shock downregulates the opioid receptors in rat brain

1985 • 43 citations

Changes in glutamate receptor and proenkephalin gene expression after kindled seizures

1994 • 43 citations

Effect of Potassium Channel Modulating Drugs on Isolated Smooth Muscle

1994 • 42 citations

Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus

1995 • 42 citations

In vitro release of [5-methionine]enkephalin and [5-leucine]-enkephalin from the rat globus pallidus

1978 • 41 citations

Alterations in somatostatin and proenkephalin mRNA in response to a single amygdaloid stimulation versus kindling

1991 • 41 citations

Activating endogenous opioid systems by electroconvulsive shock or footshock stress inhibits recurrent kindled seizures in rats

1984 • 41 citations

Localization of kappa opioid receptor binding sites in human forebrain using [3H]U69,593: Comparison with [3H]bremazocine

1987 • 39 citations

Mu and delta opioid receptors inhibit serotonin release in rat hippocampus.

1989 • 39 citations

Presynaptic plasticity: The regulation of Ca2+-dependent transmitter release

1994 • 39 citations

15 Differential release of classical transmitters and peptides

1994 • 39 citations

Presynaptic α2-adrenoceptor and κ-opiate receptor occupancy promotes closure of neuronal (N-type) calcium channels

1989 • 38 citations

Release of endogenous opiod peptides displaces [3H]diprenorphine binding in rat hippocampal slices

1989 • 37 citations

Exocytosis from large dense cored vesicles as a mechanism for neuropeptide release in the peripheral and central nervous system.

1986 • 36 citations

Morphological evidence for altered synaptic organization and structure in the hippocampal formation of seizure‐sensitive gerbils

1992 • 36 citations

kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.

1995 • 36 citations

Differential effects of methionine5 enkephalin on hippocampal pyramidal cells and interneurons

1989 • 36 citations

Induction of the rat prodynorphin gene through Gs-coupled receptors may involve phosphorylation-dependent derepression and activation.

1994 • 36 citations

Different Drug-Susceptibilities of long-term potentiation in three input systems to the CA3 region of the guinea pig hippocampus in vitro

1990 • 35 citations

Selective participation of both “enkephalinase” and aminopeptidase activities in the metabolism of endogenous enkephalins

1982 • 33 citations

Dynorphin prolongs the action potential of mouse sensory ganglion neurons by decreasing a potassium conductance whereas another specific kappa opioid does so by increasing a calcium conductance.

1990 • 33 citations

PD117302, a selective non-peptide opioid kappa agonist, protects against NMDA and maximal electroshock convulsions in rats

1990 • 33 citations

A microiontophoretic study of the actions of μ‐, δ‐ and κ‐opiate receptor agonists in the rat brain

1984 • 32 citations

Comparison of opioid and GABA receptor control of excitability and membrane conductance in hippocampal CA1 pyramidal cells in rat

1989 • 32 citations

Opiate and non-opiate aspects of morphine induced seizures

1982 • 32 citations

Opioid peptide expression in models of chronic temporal lobe epilepsy

1995 • 31 citations

Perforant path kindling induces differential alterations in the mRNA levels coding for prodynorphin and proenkephalin in the rat hippocampus

1990 • 31 citations

Different effects of dynorphin a on in vitro guinea pig hippocampal CA3 pyramidal cells with various degrees of paired-pulse facilitation

1986 • 30 citations

Peptidases that terminate the action of enkephalins. Consideration of physiological importance for amino-, carboxy-, endo-, and pseudoenkephalinase

1985 • 30 citations

Opioid peptide biosynthesis: enzymatic selectivity and regulatory mechanisms

1987 • 30 citations

Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism

1987 • 30 citations

Dynorphin prolongs the action potential of mouse sensory ganglion neurons by decreasing a potassium conductance whereas another specific kappa opioid does so by increasing a calcium conductance

1990 • 30 citations

Dynorphin-A alters the excitability of pyramidal neurons of the rat hippocampus

1983 • 29 citations

Effects of selective μ- and δ-opioid peptides on kindled amygdaloid seizures in rats

1987 • 29 citations

Ca2+ channel inhibition by K opioid receptors expressed in Xenopus oocytes

1994 • 27 citations

Effects of pertussis toxin on opioid regulation of catecholamine release from rat and guinea pig brain slices

1989 • 27 citations

Relationship between kappa1 opioid receptor binding and inhibition of adenylyl cyclase in guinea pig brain membranes

1993 • 27 citations

Kappa opioid receptor-mediated suppression of voltage-activated potassium current in a catecholaminergic neuronal cell line.

1995 • 26 citations

Modulation of the inactivation of voltage-dependent potassium channels by cAMP

1995 • 25 citations

Intrahippocampal injections of a specific μ-receptor ligand PL017 produce generalized convulsions in rats

1988 • 24 citations

Opioid receptor alterations in a genetic model of generalized epilepsy

1986 • 23 citations

Endogenous opioids released from perforant path modulate norepinephrine actions and inhibitory postsynaptic potentials in guinea pig CA3 pyramidal cells.

1991 • 23 citations

The prodynorphin system in the rat hippocampus is differentially influenced by kainic acid and pentetrazole

1992 • 22 citations

Depression of LTP in rat dentate gyrus by naloxone is reversed by GABAA blockade

1995 • 21 citations

Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by κ opioid receptors expressed in Xenopus oocytes

1994 • 21 citations

Stimulation of the perforant path alters hippocampal levels of opioid peptides, glutamine and GABA

1987 • 20 citations

LTP, post or pre? A look at the evidence for the locus of long-term potentiation.

1991 • 20 citations

Opioid-Coupled Second Messenger Systems

1988 • 18 citations

Elevation of naloxone-sensitive 3H-dihydromorphine binding in hippocampal formation of genetically epilepsy-prone rats

1988 • 18 citations

A subtype of opioid κ‐receptor is coupled to inhibition of Gil‐mediated phospholipase C activity in the guinea pig cerebellum

1995 • 18 citations

Enkephalin enhances responsiveness to perforant path input while decreasing spontaneous activity in the dentate gyrus

1987 • 18 citations

Alteration of opioid receptors in seizure-susceptible El mouse brain

1989 • 17 citations

Increase in enkephalin-like immunoreactivity in hippocampi of adults with generalized epilepsy

1994 • 17 citations

Hippocampal opioid peptides and seizures.

1992 • 17 citations

Opioids regulate cGMP formation in cloned neuroblastoma cells

1982 • 16 citations

Ventral hippocampal dentate granule cell lesions enhance motor seizures but reduce wet dog shakes induced by mu opioid receptor agonist

1990 • 16 citations

The actions of the κ1 opioid agonist U-50,488 on presynaptic nerve terminals of the chick ciliary ganglion

1993 • 16 citations

Opioid enhancement of perforant path transmission: effect of an enkephalin analog on inhibition and facilitation in the dentate gyrus

1986 • 16 citations

The effect of ?-opioid agonist U-50, 488H on wet-dog shaking behavior induced by hippocampal stimulation in rats

1987 • 15 citations

Endogenous opioid regulation of norepinephrine release in guinea pig hippocampus

1992 • 12 citations

Pertussis toxin pretreatment antagonizes the actions of μ- and δ-opiate agonists in hippocampal slices

1988 • 11 citations

Intracerebral microinjections of dermorphin

1994 • 10 citations

8-Bromo-cAMP blocks opioid activation of a voltage-gated potassium current in isolated hippocampal neurons

1992 • 8 citations

Kappa receptor immunoreactivity is present in cells and fibers of the rat forebrain

1994 • 8 citations

Deleted Work

1955 • 0 citations