Presynaptic plasticity: The regulation of Ca2+-dependent transmitter release

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The Organization of Behavior: A Neuropsychological Theory

1950 • 4,130 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Ionic Channels of Excitable Membranes

1985 • 3,014 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 2,122 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Biological Applications of Ionophores

1976 • 1,829 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

Short-Term Synaptic Plasticity

1989 • 1,464 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.

1979 • 1,408 citations

Multiple types of neuronal calcium channels and their selective modulation

1988 • 1,399 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

The role of calcium in neuromuscular facilitation

1968 • 1,331 citations

Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function

1993 • 1,302 citations

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

1992 • 1,274 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

1983 • 1,162 citations

Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate

1992 • 1,144 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Classes of Calcium Channels in Vertebrate Cells

1989 • 1,082 citations

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

1991 • 1,016 citations

Nitric Oxide: First in a New Class of Neurotransmitters

1992 • 1,001 citations

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

1992 • 968 citations

Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex

1990 • 893 citations

Dominant Role of N-Type Ca ²⁺ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons

1988 • 859 citations

Microdomains of High Calcium Concentration in a Presynaptic Terminal

1992 • 837 citations

TURNOVER OF TRANSMITTER AND SYNAPTIC VESICLES AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 835 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

Long-Term Potentiation

1987 • 804 citations

Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices

1990 • 803 citations

Calcium Action in Synaptic Transmitter Release

1987 • 742 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

1993 • 716 citations

Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse

1981 • 704 citations

Presynaptic mechanism for long-term potentiation in the hippocampus

1990 • 691 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

The syntaxin family of vesicular transport receptors

1993 • 656 citations

Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase

1992 • 644 citations

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

1987 • 640 citations

Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse

1991 • 638 citations

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.

1985 • 636 citations

Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison.

1989 • 631 citations

Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain

1985 • 625 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

A Cellular Mechanism of Classical Conditioning in Aplysia : Activity-Dependent Amplification of Presynaptic Facilitation

1983 • 620 citations

Neuropeptides in perspective: The last ten years

1991 • 620 citations

Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus

1989 • 612 citations

Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release

1985 • 609 citations

Calcium ions, active zones and synaptic transmitter release

1988 • 609 citations

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter

1992 • 594 citations

Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture.

1991 • 589 citations

Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials

1987 • 585 citations

Statistical factors involved in neuromuscular facilitation and depression

1954 • 582 citations

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis

1984 • 576 citations

Long-term potentiation phenomena in the rat limbic forebrain

1983 • 562 citations

Coexistence of peptides and classical neurotransmitters

1983 • 559 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Do GTPases direct membrane traffic in secretion?

1988 • 540 citations

Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins

1989 • 535 citations

Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice

1984 • 531 citations

Multiple calcium-dependent processes related to secretion in bovine chromaffin cells

1993 • 524 citations

Proteins of synaptic vesicles involved in exocytosis and membrane recycling

1991 • 523 citations

Calcium transport and buffering in neurons

1988 • 519 citations

Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain.

1989 • 513 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

1988 • 512 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

1993 • 504 citations

The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1.

1989 • 500 citations

A persistent postsynaptic modification mediates long-term potentiation in the hippocampus

1988 • 496 citations

A new conus peptide ligand for mammalian presynaptic Ca2+ channels

1992 • 487 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

The Biosynthesis Of Neuropeptides: Peptide Alpha-Amidation

1992 • 482 citations

Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation

1989 • 481 citations

Expression cloning of a reserpine-sensitive vesicular monoamine transporter.

1992 • 481 citations

Molecular Neurobiology of the Mammalian Brain

1987 • 481 citations

Brief bursts of high-frequency stimulation produce two types of structural change in rat hippocampus.

1980 • 474 citations

INTERACTING PHOSPHOLIPID BILAYERS: Measured Forces and Induced Structural Changes

1981 • 464 citations

Pathways to Regulated Exocytosis in Neurons

1990 • 454 citations

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

1991 • 441 citations

Currents through the fusion pore that forms during exocytosis of a secretory vesicle

1987 • 432 citations

NMDA application potentiates synaptic transmission in the hippocampus

1988 • 421 citations

Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons

1992 • 421 citations

Synapsin I bundles F-actin in a phosphorylation-dependent manner

1987 • 409 citations

Strategic location of calcium channels at transmitter release sites of frog neuromuscular synapses

1990 • 398 citations

Hypervariable C-termmal domain of rab proteins acts as a targeting signal

1991 • 394 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Rab GTPases in vesicular transport

1993 • 379 citations

Release of Glutamate, Aspartate, and γ‐Aminobutyric Acid from Isolated Nerve Terminals

1989 • 378 citations

Presynaptic calcium currents in squid giant synapse

1981 • 366 citations

The role of NMDA receptors in learning and memory

1987 • 360 citations

Glutamate uptake by brain synaptic vesicles. Energy dependence of transport and functional reconstitution in proteoliposomes.

1988 • 357 citations

Identification of Synaptophysin as a Hexameric Channel Protein of the Synaptic Vesicle Membrane

1988 • 356 citations

Frequency- and reserpine-dependent chemical coding of sympathetic transmission: Differential release of noradrenaline and neuropeptide Y from pig spleen

1986 • 355 citations

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

1992 • 354 citations

Domain structure of synaptotagmin (p65)

1991 • 350 citations

Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels

1992 • 341 citations

The organization of cytoplasm at the presynaptic active zone of a central nervous system synapse

1988 • 340 citations

Rapid Preparation of Synaptosomes from Mammalian Brain Using Nontoxic Isoosmotic Gradient Material (Percoll)

1984 • 338 citations

CONTROL OF NONMUSCLE MYOSINS BY PHOSPHORYLATION

1992 • 338 citations

Regulation of calmodulin binding to P-57. A neurospecific calmodulin binding protein.

1987 • 334 citations

Short-term synaptic plasticity is altered in mice lacking synapsin I

1993 • 332 citations

Differential release of amino acids, neuropeptides, and catecholamines from isolated nerve terminals

1991 • 330 citations

Protein phosphorylation in the nervous system

1984 • 329 citations

Depression of transmitter release at the neuromuscular junction of the frog

1970 • 322 citations

Are the presynaptic membrane particles the calcium channels?

1981 • 318 citations

The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS

1992 • 314 citations

Molecular biology of somatostatin receptors

1993 • 311 citations

Brain voltage-sensitive calcium channel subtypes differentiated by omega-conotoxin fraction GVIA.

1986 • 307 citations

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

1990 • 305 citations

Characterization of synapsin I binding to small synaptic vesicles.

1986 • 304 citations

Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action.

1992 • 301 citations

Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I

1992 • 299 citations

Repetitive Action Potentials in Isolated Nerve Terminals in the Presence of 4‐Aminopyridine: Effects on Cytosolic Free Ca²⁺ and Glutamate Release

1989 • 297 citations

Molecular characterization of synaptophysin, a major calcium-binding protein of the synaptic vesicle membrane.

1986 • 296 citations

Calcium Channels Coupled to Glutamate Release Identified by ω-Aga-IVA

1992 • 292 citations

Immunocytochemical localization of calcium/calmodulin-dependent protein kinase II in rat brain.

1984 • 292 citations

Correlation between long‐term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats.

1986 • 289 citations

Adenosine triphosphate. A constituent of cholinergic synaptic vesicles

1974 • 288 citations

Interaction of Calcitonin and Calcitonin Gene-Related Peptide at Receptor Sites in Target Tissues

1985 • 286 citations

Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes

1990 • 284 citations

Regulation of the Release of Coexisting Neurotransmitters

1988 • 283 citations

Action potential broadening and frequency-dependent facilitation of calcium signals in pituitary nerve terminals.

1991 • 281 citations

Presynaptic release probability influences the locus of long-term potentiation

1992 • 278 citations

Synaptic correlates of associative potentiation/depression: an ultrastructural study in the hippocampus

1983 • 278 citations

Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1.

1992 • 276 citations

HPC-1 is associated with synaptotagmin and omega-conotoxin receptor.

1992 • 275 citations

Phorbol Ester Enhancement of Neurotransmitter Release from Rat Brain Synaptosomes

1987 • 273 citations

Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by d(−)aminophosphonovalerate

1987 • 269 citations

Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.

1990 • 268 citations

Inhibition of noradrenaline release by antibodies to B-50 (GAP-43)

1989 • 267 citations

Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.

1988 • 262 citations

Exocytosis

1990 • 260 citations

GE: A GTP-Binding Protein Mediating Exocytosis

1990 • 256 citations

MYOSIN-I

1991 • 252 citations

Binding of synaptotagmin to the α-latrotoxin receptor implicates both in synaptic vesicle exocytosis

1991 • 251 citations

A low affinity Ca2+ receptor controls the final steps in peptide secretion from pituitary melanotrophs

1993 • 243 citations

Induction of hippocampal long-term potentiation using physiologically patterned stimulation

1986 • 242 citations

Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C

1989 • 241 citations

Amino acid neurotransmission: spotlight on synaptic vesicles

1990 • 237 citations

Are dihydropyridine binding sites voltage sensitive calcium channels?

1984 • 234 citations

A role for synaptotagmin (p65) in regulated exocytosis

1993 • 233 citations

Synaptotagmin II. A novel differentially distributed form of synaptotagmin

1991 • 231 citations

Primary Changes of Membrane Currents During Retention of Associative Learning

1982 • 229 citations

Ca2+-dependent and Ca2+- independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: Possible relevance to hyoglycaemia and anoxia

1988 • 228 citations

Association of Rab3A with synaptic vesicles at late stages of the secretory pathway.

1991 • 222 citations

Ultrastructure of the ‘active zone’ in the frog neuromuscular junction

1973 • 221 citations

Synaptic vesicle membrane proteins interact to form a multimeric complex.

1992 • 219 citations

Calcium channels in rat brain synaptosomes: identification and pharmacological characterization. High affinity blockade by organic Ca2+ channel blockers

1985 • 218 citations

Long‐term enhancement of CA1 synaptic transmission is due to increased quantal size, not quantal content

1991 • 218 citations

Exocytosis from large dense cored vesicles outside the active synaptic zones of terminals within the trigeminal subnucleus caudalis: A possible mechanism for neuropeptide release

1986 • 216 citations

Long-term potentiation : a debate of current issues

1991 • 216 citations

Bioenergetics of secretory vesicles

1986 • 211 citations

Cytosolic Ca2+, exocytosis, and endocytosis in single melanotrophs of the rat pituitary

1990 • 208 citations

Relationship between transmitter release and presynaptic calcium influx when calcium enters through discrete channels.

1986 • 207 citations

Adenosine triphosphate-dependent uptake of glutamate into protein I-associated synaptic vesicles.

1983 • 206 citations

Synapsin I in Nerve Terminals: Selective Association with Small Synaptic Vesicles

1984 • 205 citations

The effects of some organic "calcium antagonists" on calcium influx in presynaptic nerve terminals.

1979 • 205 citations

Stimulation-Dependent Alterations in Peroxidase Uptake at Lobster Neuromuscular Junctions

1971 • 202 citations

Direct relation of long-term synaptic potentiation to phosphorylation of membrane protein F1, a substrate for membrane protein kinase C

1986 • 201 citations

A selective increase in phosphorylation of protein F1, a protein kinase C substrate, directly related to three day growth of long term synaptic enhancement

1985 • 200 citations

Multiple neuropeptides derived from a common precursor are differentially packaged and transported

1988 • 196 citations

Exocytosis from Neuronal Large Dense-Cored Vesicles

1990 • 196 citations

Concentration Profiles of Intracellular Calcium in the Presence of a Diffusible Chelator

1986 • 196 citations

Calcium channel regulation by calcineurin, a Ca2+-activated phosphatase in mammalian brain

1989 • 195 citations

Vesicle recycling and transmitter release

1979 • 195 citations

Role of residual calcium in synaptic depression and posttetanic potentiation: Fast and slow calcium signaling in nerve terminals

1991 • 193 citations

The fine structure of freeze-fractured presynaptic membranes

1972 • 192 citations

Structure and function of the synapsins.

1992 • 192 citations

Short-Term and Long-Term Plasticity and Physiological Differentiation of Crustacean Motor Synapses

1986 • 192 citations

Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4

1993 • 190 citations

High Sensitivity of Glutamate Uptake to Extracellular Free Arachidonic Acid Levels in Rat Cortical Synaptosomes and Astrocytes

1992 • 188 citations

Presynaptic Glutamate Receptors Modulate Dopamine Release from Striatal Synaptosomes

1991 • 188 citations

Transmitter release from synapses: Does a preassembled fusion pore initiate exocytosis?

1990 • 186 citations

Resolution of adenylate cyclase sensitive and insensitive to Ca2+ and calcium-dependent regulatory protein (CDR) by CDR-sepharose affinity chromatography.

1979 • 185 citations

Anti-α-fodrin inhibits secretion from permeabilized chromaffin cells

1987 • 184 citations

Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: Importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation and resupply by axonal transport

1989 • 184 citations

Ultrastructural localization of nitric oxide synthese immunoreactivity in guinea-pig enteric neurons

1992 • 183 citations

Calcium-independent release of amino acid neurotransmitters: Fact or artifact?

1992 • 179 citations

Neurotransmitter Release from Synaptotagmin-Deficient Clonal Variants of PC 12 Cells

1992 • 178 citations

Protein phosphorylation in the nervous system.

1985 • 177 citations

Synapsin I: an actin-bundling protein under phosphorylation control.

1987 • 176 citations

Separation of synaptic vesicles of different functional states from the cholinergic synapses of the Torpedo electric organ

1977 • 175 citations

Uptake of GABA by rat brain synaptic vesicles isolated by a new procedure.

1988 • 174 citations

Localization of calcium in presynaptic nerve terminals. An ultrastructural and electron microprobe analysis.

1980 • 174 citations

Synapsin I: A synaptic vesicle-associated neuronal phosphoprotein

1986 • 168 citations

Long-term potentiation in the hippocampus

1983 • 167 citations

Dopamine- -hydroxylase: regulation of its synthesis and release from nerve terminals.

1972 • 167 citations

l-Glutamate-evoked release of dopamine from synaptosomes of the rat striatum: Involvement of AMPA and N-methyl-d-aspartate receptors

1992 • 166 citations

Regulation of Neuropeptide Gene Expression

1990 • 165 citations

The physiological role of calcium-dependent channels

1989 • 164 citations

Phosphorylation of the presynaptic protein B-50 (GAP-43) is increased during electrically induced long-term potentiation

1992 • 160 citations

Homology and analogy in transmembrane channel design: lessons from synaptic membrane proteins

1990 • 159 citations

Presynaptic calcium and serotonin-mediated enhancement of transmitter release at crayfish neuromuscular junction

1991 • 158 citations

Transmitter Glutamate Release from Isolated Nerve Terminals: Evidence for Biphasic Release and Triggering by Localized Ca²⁺

1991 • 158 citations

An Ion Channel Locus for the Protein Kinase C Potentiation of Transmitter Glutamate Release from Guinea Pig Cerebrocortical Synaptosomes

1991 • 154 citations

Transmembrane Topography and Evolutionary Conservation of Synaptophysin

1989 • 153 citations

Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: An in vivo study in the dentate gyrus of the rat

1989 • 153 citations

Adenosine decreases neurotransmitter release at central synapses.

1992 • 151 citations

Cellular And Molecular Biology Of The Presynaptic Nerve Terminal

1991 • 150 citations

The neurotransmitter amino acid transport systems

1987 • 150 citations

Genetic and biochemical analysis of vesicular traffic in yeast

1992 • 138 citations

⁴⁵Ca²⁺ Uptake into Rat Whole Brain Synaptosomes Unaltered by Dihydropyridine Calcium Antagonists

1983 • 137 citations

Synapsin I is a microtubule-bundling protein

1986 • 137 citations

Presynaptic calcium diffusion and the time courses of transmitter release and synaptic facilitation at the squid giant synapse

1983 • 135 citations

Initial release of [3H]dopamine from rat striatal synaptosomes: correlation with calcium entry

1983 • 135 citations

Synaptophysin (p38) at the frog neuromuscular junction: its incorporation into the axolemma and recycling after intense quantal secretion.

1988 • 134 citations

Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles

1993 • 134 citations

Protein Kinases in the Brain

1985 • 134 citations

Uptake of γ‐Aminobutyric Acid by a Synaptic Vesicle Fraction Isolated from Rat Brain

1988 • 134 citations

Relative properties and localizations of synaptic vesicle protein isoforms: the case of the synaptophysins

1993 • 127 citations

Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin.

1991 • 126 citations

Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom.

1990 • 125 citations

ROLE OF CALMODULIN IN NEUROTRANSMITTER RELEASE AND SYNAPTIC FUNCTION*

1980 • 125 citations

The Inhibitory Effects of Omega‐Conotoxins on Ca Channels and Synapses^a

1989 • 125 citations

Membrane fusion: from liposomes to biological membranes

1984 • 123 citations

Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes.

1987 • 119 citations

Active transport of gamma-aminobutyric acid and glycine into synaptic vesicles.

1989 • 119 citations

A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4

1993 • 117 citations

Presynaptic calcium channels in rat cortical synaptosomes: fast- kinetics of phasic calcium influx, channel inactivation, and relationship to nitrendipine receptors

1986 • 116 citations

Action potentials must admit calcium to evoke transmitter release

1991 • 115 citations

Modulation of gated ion channels as a mode of transmitter action

1983 • 115 citations

A Pertussis Toxin-Sensitive G Protein in Hippocampal Long-Term Potentiation

1989 • 114 citations

Neurochemical evidence for the involvement of N-type calcium channels in transmitter secretion from peripheral endings of sensory nerves in guinea pigs

1990 • 111 citations

Presynaptic Glutamate Receptors Regulate Noradrenaline Release from Isolated Nerve Terminals

1992 • 111 citations

Measurement of intrasynaptosomal free calcium by using the fluorescent indicator quin-2

1984 • 111 citations

Synaptotagmin: A calcium-sensitive inhibitor of exocytosis?

1993 • 107 citations

Release of LHRH is linearly related to the time integral of presynaptic Ca+ elevation above a threshold level in bullfrog sympathetic ganglia

1993 • 106 citations

The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release

1991 • 104 citations

VESICULAR STORAGE AND RELEASE OF ACETYLCHOLINE IN TORPEDO ELECTROPLAQUE SYNAPSES

1978 • 103 citations

Spider Toxins: Recent Applications in Neurobiology

1989 • 102 citations

Membrane potential has no direct role in evoking neurotransmitter release

1988 • 102 citations

Calmodulin and its role in intracellular calcium regulation

1987 • 100 citations

rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence

1991 • 99 citations

BAY K 8644, a 1,4‐Dihydropyridine Ca²⁺ Channel Activator: Dissociation of Binding and Functional Effects in Brain Synaptosomes

1984 • 99 citations

Activation of quisqualate metabotropic receptors reduces glutamate and GABA-mediated synaptic potentials in the rat striatum

1992 • 94 citations

Noradrenaline inhibits central serotonin release through alpha2-adrenoceptors located on serotonergic nerve terminals

1982 • 94 citations

Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes

1988 • 93 citations

Kindling induced changes in parvalbumin immunoreactivity in rat hippocampus and its relation to long-term decrease in GABA-immunoreactivity

1989 • 92 citations

Membrane depolarization evokes neurotransmitter release in the absence of calcium entry

1989 • 90 citations

Secretory Vesicle-Associated Proteins and Their Role in Exocytosis

1990 • 90 citations

Adenosine A₁ Receptor Inhibition of Glutamate Exocytosis and Protein Kinase C‐Mediated Decoupling

1993 • 89 citations

Hippocampal slices of kindled rats reveal calcium involvement in epileptogenesis

1985 • 89 citations

Corelease of VIP and acetylcholine in relation to blood flow and salivary secretion in cat submandibular salivary gland

1982 • 88 citations

The geranylgeranyl moiety but not the methyl moiety of the smg-25A/rab3A protein is essential for the interactions with membrane and its inhibitory GDP/GTP exchange protein.

1992 • 86 citations

Selective Release of Spermine and Spermidine from the Rat Striatum by N‐Methyl‐<scp>d</scp>‐Aspartate Receptor Activation In Vivo

1992 • 86 citations

Investigations of the roles of dihydropyridine and ?-conotoxin-sensitive calcium channels in mediating depolarisation-evoked endogenous dopamine release from striatal slices

1989 • 84 citations

Synaptophysin binds to physophilin, a putative synaptic plasma membrane protein.

1990 • 83 citations

Presynaptic facilitation of glutamate release from isolated hippocampal mossy fiber nerve endings by arachidonic acid

1990 • 82 citations

A Microdialysis Study of the Regulation of Endogenous Noradrenaline Release in the Rat Hippocampus

1991 • 82 citations

Corelease of vasoactive intestinal polypeptide and peptide histidine isoleucine in relation to atropine-resistant vasodilation in cat submandibular salivary gland

1984 • 82 citations

Trans-ACPD and l-APB presynaptically inhibit excitatory glutamatergic transmission in the basolateral amygdala (BLA)

1992 • 80 citations

Presynaptic muscarinic receptors increase striatal dopamine release evoked by ‘quasi-physiological’ depolarization

1982 • 79 citations

Facilitation of transmission from autonomic nerve to smooth muscle of guinea‐pig vas deferens

1964 • 78 citations

A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein.

1991 • 78 citations

Polyamines contribute to calcium-stimulated release of aspartate from brain particulate fractions

1986 • 78 citations

Ca²⁺‐Dependent Regulation of Presynaptic Stimulus‐Secretion Coupling

1989 • 77 citations

ω‐Aga‐I: A presynaptic calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta

1989 • 76 citations

A phorbol ester and A23187 act synergistically to release acetylcholine from the guinea pig ileum

1984 • 76 citations

Trans-ACPD depresses synaptic transmission in the hippocampus

1991 • 75 citations

Stimulation of Phospholipase A₂ and Secretion of Catecholamines from Brain Synaptosomes by Potassium and A23187

1983 • 73 citations

Transfer of synaptic vesicle antigens to the presynaptic plasma membrane during exocytosis.

1981 • 72 citations

Changes in synaptic membrane phosphorylation after tetanic stimulation in the dentate area of the rat hippocampal slice

1980 • 68 citations

Redistribution of synaptic vesicles during long-term potentiation in the hippocampus

1987 • 67 citations

Barium ions enter chromaffin cells via voltage-dependent calcium channels and induce secretion by a mechanism independent of calcium

1989 • 67 citations

The calcium channel antagonist ω-conotoxin inhibits secretion from peptidergic nerve terminals

1988 • 66 citations

Transmitter release from presynaptic terminals of electric organ: inhibition by the calcium channel antagonist omega Conus toxin.

1987 • 65 citations

Depolarization‐Induced Phosphorylation of the Protein Kinase C Substrate B‐50 (GAP‐43) in Rat Cortical Synaptosomes

1990 • 65 citations

Physicochemical and hydrodynamic characterization of P-57, a neurospecific calmodulin binding protein

1986 • 64 citations

Uptake of L-[3H] glutamic acid by crude and purified synaptic vesicles from rat brain

1982 • 63 citations

α‐Latrotoxin Releases Both Vesicular and Cytoplasmic Glutamate from Isolated Nerve Terminals

1990 • 63 citations

Regulated Secretory Pathways of Neurons and Their Relation to the Regulated Secretory Pathway of Endocrine Cells

1987 • 62 citations

Excitatory amino acid-evoked release of [3H]GABA from hippocampal neurons in primary culture

1989 • 62 citations

Overcoming barriers to exocytosis

1987 • 61 citations

Evaluation of the Ca²⁺ Concentration in Purified Nerve Terminals: Relationship Between Ca²⁺ Homeostasis and Synaptosomal Preparation

1988 • 60 citations

Opioid receptor sub-types involved in the control of transmitter release in cortex of the brain of the rat

1984 • 60 citations

Regional distribution and in vivo release of tachykinin-like immunoreactivities in rat brain: evidence for regional differences in relative proportions of tachykinins

1985 • 57 citations

The role of the metabotropic receptor in synaptic plasticity

1991 • 57 citations

Inhibition of transmitter release by adenosine: are Ca2+ currents depressed or are the intracellular effects of Ca2+ impaired?

1986 • 56 citations

Pre- and postsynaptic actions of baclofen: blockade of the late synaptically-evoked hyperpolarization of CA1 hippocampal neurones

1986 • 56 citations

Calmodulin-dependent protein kinase and associated substrates in Torpedo electric organ.

1983 • 55 citations

Relation of Acetylcholine Release to Ca²⁺ Uptake and Intraterminal Ca²⁺ Concentration in Guinea‐Pig Cortex Synaptosomes

1987 • 54 citations

Evaluation of the annexins as potential mediators of membrane fusion in exocytosis

1990 • 53 citations

Long-term potentiation in the hippocampus of the anaesthetized rat is not associated with a sustained enhanced release of endogenous excitatory amino acids

1989 • 52 citations

Evidence for the Binding of Calmodulin to Endogenous B‐50 (GAP‐43) in Native Synaptosomal Plasma Membranes

1990 • 52 citations

Multiple components of synaptosomal [3H]-.gamma.-aminobutyric acid release resolved by a rapid superfusion system

1989 • 52 citations

Characterization of the Release of Cholecystokinin‐8 from Isolated Nerve Terminals and Comparison with Exocytosis of Classical Transmitters

1991 • 52 citations

Serotonin type-2 receptor mediated regulation of substance P release in the ventral spinal cord and the effects of chronic antidepressant treatment

1986 • 50 citations

Differential sensitivity of synaptosomal calcium entry and endogenous dopamine release to ω-conotoxin

1988 • 49 citations

Separation of Recycling and Reserve Synaptic Vesicles from Cholinergic Nerve Terminals of the Myenteric Plexus of Guinea Pig Ileum

1985 • 48 citations

Characterization of the effects of ω‐conotoxin GVIA on the responses of voltage‐sensitive calcium channels

1989 • 45 citations

A toxin (Aga-GI) from the venom of the spider Agelenopsis aperta inhibits the mammalian presynaptic Ca2+ channel coupled to glutamate exocytosis

1992 • 44 citations

Differential antagonism of transmitter release by subtypes of omega-agatoxins

1991 • 42 citations

Co‐operative action of calcium ions in dopamine release from rat brain synaptosomes.

1987 • 41 citations

ω-Conotoxin GVIA and dihydropyridines discriminate two types of Ca2+ channels involved in GABA release from striatal neurons in culture

1990 • 39 citations

Bicarbonate and magnesium ion-ATP dependent stimulation of acetylcholine uptake by Torpedo electric organ synaptic vesicles

1980 • 38 citations

Adenosine antagonists increase spontaneous and evoked transmitter release from neuronal cells in culture

1987 • 38 citations

Multiple calcium channels in synaptosomes: voltage dependence of 1,4-dihydropyridine binding and effects on function

1988 • 36 citations

Membrane phosphoproteins of rat hippocampus: Sensitivity to tetanic stimulation and enkephalin

1982 • 35 citations

The calcium channel antagonist, ω-conotoxin, and electric organ nerve terminals: binding and inhibition of transmitter release and calcium influx

1988 • 35 citations

Serotonectin and the family of proteins that bind serotonin

1984 • 34 citations

ω-Agatoxins differentially block calcium channels in locust, chick and rat synaptosomes

1992 • 34 citations

Photoaffinity labeling of brain adenylate cyclase preparations with azido[125I]iodocalmodulin

1983 • 33 citations

Calcitonin gene-related peptide modulates calcium mobilization in synaptosomes of rat spinal dorsal horn

1988 • 32 citations

Inhibition by Cyclic AMP of Phorbol Ester‐Potentiated Norepinephrine Release from Guinea Pig Brain Cortical Synaptosomes

1988 • 32 citations

Endogenous Noradrenaline and Dopamine in Nerve Terminals of the Hippocampus: Differences in Levels and Release Kinetics

1992 • 32 citations

Presynaptic Aspects of Cotransmission: Relationship Between Vesicles and Neurotransmitters

1989 • 32 citations

Inositol 1,4,5-trisphosphate induced mobilization of Ca2+ from rat brain synaptosomes

1987 • 30 citations

In vitro andin vivo release of neurokinin A-like immunoreactivity from rat substantia nigra

1988 • 30 citations

Important factors in induction of long-term potentiation in thin hippocampal sections

1981 • 30 citations

A novel 1,4-dihydropyridine-binding site on mitochondrial membranes from guinea-pig heart, liver and kidney

1988 • 29 citations

3-aminopropanephosphinic acid is a potent agonist at peripheral and central presynaptic GABAB receptors

1990 • 28 citations

Strengthening the synapses

1989 • 28 citations

Ionic Basis of Inhibitory Presynaptic Modulation in Rat Cortical Synaptosomes

1990 • 26 citations

Transmitter release triggered by a local depolarization in motor nerve terminals of the frog: Role of calcium entry and of depolarization

1983 • 26 citations

Facilitation as a tool to study the entry of calcium and the mechanism of neurotransmitter release

1989 • 25 citations

Enhancement of Endogenous Release of Glutamate and γ‐Aminobutyric Acid from Hippocampus CA1 Slices After In Vivo Long‐Term Potentiation

1992 • 25 citations

Dephosphin, a 96 000 Da substrate of protein kinase C in synaptosomal cytosol, is phosphorylated in intact synaptosomes

1991 • 25 citations

Calcium-dependent potassium-stimulated release of neurokinin a and neurokinin B from rat brain regions

1985 • 24 citations

Involvement of Ca2+ uptake by a reticulum-like store in the control of transmitter release

1992 • 24 citations

Membrane retrieval following exocytosis in isolated neurosecretory nerve endings

1992 • 24 citations

Synaptic vesicles

1989 • 23 citations

Phorbol Esters Potentiate Rapid Dopamine Release from Median Eminence and Striatal Synaptosomes*

1988 • 23 citations

Quantitative correlation between tetanus-induced decreases in extracellular calcium and LTP

1988 • 22 citations

Muscarinic Agonists Evoke Neurotransmitter Release: Possible Roles for Phosphatidyl Inositol Bisphosphate Breakdown Products in Neuromodulation

1988 • 22 citations

Inhibition of a dihydropyridine, ω-conotoxin insensitive Ca2+ channel in rat synaptosomes by venom of the spider Hololena curta

1992 • 19 citations

Quantitative relationship between post-tetanic biochemical and electrophysiological changes in rat hippocampal slices

1983 • 19 citations

Divalent cations effectively replace Ca2+ and support bradykinin induced noradrenaline release

1990 • 18 citations

The increase in [3H]glutamate release associated with long-term potentiation in the dentate gyrus is blocked by commissural stimulation

1989 • 17 citations

Cholinergic synaptic vesicles are metabolically and biophysically heterogeneous even in resting terminals

1990 • 17 citations

Two High‐Threshold Ca²⁺ Channels Contribute Ca²⁺ for Depolarization‐Secretion Coupling in the Mammalian Neurohypophysis

1991 • 16 citations

Perfusion of Immobilized Isolated Nerve Terminals as a Model for the Regulation of Transmitter Release: Release of Different, Endogenous Transmitters, Repeated Stimulation, and High Time Resolution

1992 • 14 citations

Effect of ?-conotoxin GVIA on release of 3H-?-aminobutyric acid from slices of rat neostriatum

1989 • 14 citations

Classical Conditioning‐Induced Changes in Low‐Molecular‐Weight GTP‐Binding Proteins in Rabbit Hippocampus

1991 • 13 citations

Galanin increases potassium evoked release of [3H]5-hydroxytryptamine from rat hypothalamic synaptosomal preparations

1991 • 11 citations

Cyclic GMP and protein kinase G inhibit the quantal transmitter release induced by protein kinase C

1988 • 9 citations

Activity-dependent recruitment of endogenous glutamate for exocytosis

1991 • 8 citations

Cross-linking of synaptic vesicle proteins

1982 • 8 citations

Characterization of the release of Met-enkephalin from isolated nerve terminals: release kinetics and cation-dependence

1992 • 5 citations

Tertiary templates and compact units in protein design

1987 • 3 citations

Freeze-Fracture (-Etching) Analysis of Exo-Endocytosis

2018 • 1 citations