Opioid Actions on Membrane Ion Channels

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

Opioids excite dopamine neurons by hyperpolarization of local interneurons

1992 • 1,585 citations

Diversity and ubiquity of K channels

1988 • 1,342 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

Adenosine 5'-Triphosphate-Sensitive Potassium Channels

1988 • 888 citations

A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones

1984 • 878 citations

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

1989 • 815 citations

Varieties of Calcium-Activated Potassium Channels

1989 • 731 citations

Calcium Channels in Excitable Cell Membranes

1983 • 725 citations

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

1987 • 616 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart

1983 • 471 citations

Calcium Channels in Vertebrate Cells

1990 • 454 citations

Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates

1990 • 442 citations

Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids

1989 • 426 citations

Ionic Channels and Their Regulation by G Protein Subunits

1990 • 413 citations

Electrophysiology of opioids.

1983 • 377 citations

Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate

1974 • 373 citations

Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons

1990 • 341 citations

Enkephalin blocks inhibitory pathways in the vertebrate CNS

1980 • 334 citations

The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat

1976 • 321 citations

A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors

1974 • 316 citations

Drug receptors and the inhibition of nerve cells

1989 • 308 citations

Enkephalin hyperpolarizes interneurones in the rat hippocampus.

1988 • 296 citations

Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.

1988 • 280 citations

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

1987 • 266 citations

On the potassium conductance increased by opioids in rat locus coeruleus neurones.

1985 • 265 citations

Enkephalin opens potassium channels on mammalian central neurones

1982 • 264 citations

Regulatory peptides from molecular biology to function.

1982 • 263 citations

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

1987 • 260 citations

Pertussis toxin blocks the outward currents evoked by opiate and α2-agonists in locus coeruleus neurons

1986 • 241 citations

Newly Identified Brain Potassium Channels Gated by the Guanine Nucleotide Binding Protein G _o

1988 • 236 citations

Substantia gelatinosa neurones hyperpolarized in vitro by enkephalin

1983 • 236 citations

Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in Vitro

1980 • 229 citations

Regulation of transmitter release at the squid giant synapse by presynaptic delayed rectifier potassium current.

1990 • 226 citations

Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells.

1986 • 218 citations

Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture

1989 • 217 citations

Opioid actions on single nucleus raphe magnus neurons from rat and guinea‐pig in vitro.

1990 • 202 citations

Activation of μ opioid receptors inhibits transient high- and low-threshold Ca 2+ currents, but spares a sustained current

1991 • 202 citations

Calcium permeability of the nicotinic acetylcholine receptor: the single-channel calcium influx is significant

1990 • 178 citations

Iontophoresis and transmitter mechanisms in the mammalian central nervous system

1978 • 176 citations

Pre- and postsynaptic inhibition by opioids in rat striatum

1992 • 176 citations

Mechanisms of cellular adaptive sensitivity changes: applications to opioid tolerance and dependence.

1989 • 176 citations

Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurons

1988 • 169 citations

Opiate-receptor interactions on single locus coeruleus neurones.

1984 • 166 citations

Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture

1978 • 163 citations

Mu and kappa opioids inhibit transmitter release by different mechanisms.

1985 • 161 citations

Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells

1989 • 159 citations

The actions of neuropeptides on dorsal horn neurons in the rat spinal cord slice preparation: an intracellular study

1982 • 159 citations

Iontophoresis and transmitter mechanisms in the mammalian central nervous system

1979 • 158 citations

Somatostatin increases an inwardly rectifying potassium conductance in guinea‐pig submucous plexus neurones.

1987 • 154 citations

Opioid peptides selective for mu- and delta-opiate receptors reduce calcium-dependent action potential duration by increasing potassium conductance

1983 • 151 citations

Dynorphin A decreases voltage‐dependent calcium conductance of mouse dorsal root ganglion neurones.

1986 • 150 citations

Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea‐pig submucosal neurones.

1990 • 146 citations

Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation

1991 • 145 citations

Morphine tolerance and dependence in the locus coeruleus: Single cell studies in brain slices

1983 • 139 citations

GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels.

1988 • 134 citations

Agonists at μ‐opioid, M₂ ‐muscarinic and GABA_B ‐receptors increase the same potassium conductance in rat lateral parabrachial neurones

1988 • 130 citations

THE MECHANISM OF ACTION OF NARCOTIC ANALGESICS IN THE GUINEA‐PIG ILEUM

1977 • 130 citations

Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration.

1985 • 124 citations

Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of rat brain: regulation by acute and chronic morphine

1989 • 122 citations

μ-Opioid-receptor-mediated inhibidon of the N-type calcium-channel current

1991 • 120 citations

Mechanism of synaptic inhibition by noradrenaline acting at α ₂ -adrenoceptors

1988 • 107 citations

Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents.

1990 • 104 citations

Opioids increase potassium conductance in submucous neurones of guinea‐pig caecum by activating δ‐receptors

1986 • 89 citations

Neurotransmitter modulation of calcium current in rat spinal cord neurons

1990 • 87 citations

Opioids Hyperpolarize β-Endorphin Neurons via μ-Receptor Activation of a Potassium Conductance

1990 • 86 citations

Kappa opioid receptor activation depresses excitatory synaptic input to rat locus coeruleus neurons in vitro

1987 • 81 citations

Potassium conductance increased by noradrenaline, opioids, somatostatin, and G-proteins: whole-cell recording from guinea pig submucous neurons

1990 • 79 citations

Opioids act at μ-receptors to hyperpolarize arcuate neurons via an inwardly rectifying potassium conductance

1990 • 71 citations

Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures

1988 • 70 citations

Enkephalins modulate excitatory synaptic transmission in the superficial dorsal horn by acting at μ-opioid receptor sites

1988 • 65 citations

Inhibitor of cyclic AMP-dependent protein kinase blocks opioid-induced prolongation of the action potential of mouse sensory ganglion neurons in dissociated cell cultures

1988 • 64 citations

How do opiates inhibit neurotransmitter release?

1983 • 56 citations

Membrane properties and response to opioids of identified dopamine neurons in the guinea pig hypothalamus

1990 • 56 citations

Potassium channels opened by noradrenaline and other transmitters in excised membrane patches of guinea‐pig submucosal neurones.

1992 • 56 citations

Influence of morphine and naloxone on the release of noradrenaline from rat cerebellar cortex slices

1975 • 47 citations

Noradrenaline‐ and Enkephalin‐Induced Inhibition of Voltage‐Sensitive Calcium Currents in NG108‐15 Hybrid Cells

1989 • 46 citations

Morphine enhances and depresses Ca2+-dependent responses in visceral primary afferent neurons

1982 • 45 citations

Mechanisms underlying presynaptic inhibition through alpha 2‐adrenoceptors in guinea‐pig submucosal neurones.

1990 • 42 citations

Noradrenergic terminal excitability: Effects of opioids

1982 • 41 citations

Maturation of opioid sensitivity of fetal mouse dorsal root ganglion neuron perikarya in organotypic cultures: Regulation by spinal cord

1986 • 40 citations

Characterization of two components of the N-like, high-threshold-activated calcium channel current in differentiated SH-SY5Y cells

1990 • 38 citations

INHIBITION OF NEURONAL FIRING BY OPIATES: EVIDENCE AGAINST THE INVOLVEMENT OF CYCLIC NUCLEOTIDES

1979 • 36 citations

Hyperpolarisation and depression of slow synaptic inhibition by enkephalin in frog sympathetic ganglion

1979 • 36 citations

Two components of high-threshold Ca2+ current inactivate by different mechanisms

1990 • 35 citations

Effect of opioid peptides on the paraventricular nucleus of the guinea pig hypothalamus is mediated by μ-type receptors

1988 • 34 citations

Calcium Channels in Vertebrate Neurons

1989 • 32 citations

Activation of mu opioid receptors inhibits transient high- and low-threshold Ca currents, but spares a sustained current

1991 • 29 citations

Direct effects of an opioid peptide selective for μ-receptors: Intracellular recordings in the paraventricular and supraoptic nuclei of the guinea-pig

1990 • 28 citations

Dihydropyridine Bay K 8644 activates T lymphocyte calcium-permeable channels.

1988 • 18 citations

Hyperpolarizing action of enkephalin on neurons in the dorsal motor nucleus of the vagus, in vitro

1990 • 14 citations

Activation of enkephalin receptors reduces calcium conductance in neuroblastoma cells

1987 • 12 citations

Membrane Potential Measured During Potassium‐Evoked Release of Noradrenaline from Rat Brain Neurons: Effects of Normorphine

1986 • 11 citations

Modulation of Ca²⁺‐Channel Currents in Sensory Neurons by Pertussis Toxin‐Sensitive G‐Proteins^a

1989 • 7 citations