Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task.

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.

1979 • 1,970 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 • 628 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Spatial learning and motor deficits in aged rats

1984 • 509 citations

Sequence and expression of the rat prodynorphin gene.

1985 • 382 citations

An evaluation of spatial information processing in aged rats.

1987 • 353 citations

The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system

1987 • 318 citations

Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.

1980 • 285 citations

Rat striatal methionine-enkephalin content after chronic treatment with cataleptogenic and noncataleptogenic antischizophrenic drugs.

1978 • 276 citations

Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats.

1986 • 231 citations

Age pigments, cell loss and hippocampal function

1979 • 170 citations

Opiate Antagonists Improve Spatial Memory

1983 • 162 citations

Age-Related Changes in Central Nervous System Beta-Endorphin and ACTH

1980 • 120 citations

Decrease in the number of synapses in the senescent brain: A quantitative electron microscopic analysis of the dentate gyrus molecular layer in the rat

1976 • 119 citations

Electrical stimulation in vivo increases the expression of proenkephalin mRNA and decreases the expression of prodynorphin mRNA in rat hippocampal granule cells.

1988 • 117 citations

Partial deafferentation of neurons in the dentate gyrus of the senescent rat

1977 • 102 citations

Age-dependent changes in the β-endorphin content of discrete rat brain nuclei

1981 • 100 citations

Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4

1986 • 99 citations

Age-related changes in central nervous system enkephalins and substance P

1981 • 95 citations

Dynorphin- and enkephalin-like immunoreactivity is altered in limbic-basal ganglia regions of rat brain after repeated electroconvulsive shock.

1986 • 82 citations

Amygdaloid kindling increases enkephalin-like immunoreactivity but decreases dynorphin-A-like immunoreactivity in rat hippocampus

1986 • 74 citations

Effects of opiate antagonists on spatial memory in young and aged rats

1985 • 69 citations

A survey of substance P, somatostatin, and neurotensin levels in aging in the rat and human central nervous system

1981 • 67 citations

Selective impairment of declarative memory following stimulation of dentate gyrus granule cells: a naloxone-sensitive effect

1984 • 54 citations

Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin

1980 • 49 citations

Senescent change in tissue weight and immunoreactive β-endorphin, enkephalin, and vasopressin in eight regions of C57BL/6J mouse brain and pituitary

1985 • 29 citations

Stimulation of the perforant path alters hippocampal levels of opioid peptides, glutamine and GABA

1987 • 20 citations

Opioid peptide identity and localization in hippocampus

1982 • 17 citations

Age-related decreases in the concentration of Met-and Leu-enkephalin and neurotensin in the basal ganglia of rats

1987 • 14 citations