Focal Stimulation of the Mossy Fibers Releases Endogenous Dynorphins That Bind _K1‐Opioid Receptors in Guinea Pig Hippocampus

Endogenous Opioids: Biology and Function

1984 • 1,223 citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

1988 • 1,202 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain

1988 • 980 citations

Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

1982 • 448 citations

[3H]U-69593 a highly selective ligand for the opioid κ receptor

1985 • 439 citations

Specific receptor for the opioid peptide dynorphin: structure--activity relationships.

1981 • 411 citations

Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype.

1989 • 331 citations

Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors.

1988 • 315 citations

Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity.

1983 • 289 citations

Nonopiate Effects of Dynorphin and Des-Tyr-Dynorphin

1982 • 235 citations

Methods used for the study of opioid receptors.

1987 • 209 citations

Distribution of opiate receptor subtypes and enkephalin and dynorphin immunoreactivity in the hippocampus of squirrel, guinea pig, rat, and hamster

1987 • 180 citations

Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus

1985 • 131 citations

The distribution and morphology of opioid peptide immunoreactive neurons in the cerebral cortex of rats

1984 • 120 citations

Affinity of drugs and peptides for U-69,593-sensitive and -insensitive kappa opiate binding sites: the U-69,593-insensitive site appears to be the beta endorphin-specific epsilon receptor.

1990 • 97 citations

Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus.

1988 • 94 citations

Quantitative autoradiographic analysis of Mu and delta opioid binding sites in the rat hippocampal formation

1986 • 80 citations

Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus.

1983 • 74 citations

Bidentate peptides: Highly potent new inhibitors of enkephalin degrading enzymes

1984 • 60 citations

Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat

1985 • 56 citations

[3H]U-69593 labels a subtype of kappa opiate receptor with characteristics different from that labeled by [3H]ethylketocyclazocine

1988 • 55 citations

Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus

1990 • 52 citations

Pharmacological activities of optically pure enantiomers of the κ opioid agonist, U50,488, and its cis diastereomer: evidence for three κ receptor subtypes

1989 • 49 citations

Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-A and -B may act on μ-receptors in the CA1 region

1985 • 47 citations

Activation of receptors contributes to the EPSP at perforant path synapses in the rat dentate gyrus in vitro

1989 • 46 citations

Video and scanning microdensitometer-based imaging systems in autoradiographic densitometry

1984 • 45 citations

Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig.

1990 • 40 citations

Ontogeny of enkephalin-like immunoreactivity in the rat hippocampus

1984 • 37 citations

Release of endogenous opiod peptides displaces [3H]diprenorphine binding in rat hippocampal slices

1989 • 37 citations

Characterization of kappa opioid binding using dynorphin A1-13 and U69,593 in the rat brain.

1990 • 30 citations

Comparison of in vitro potencies in pharmacological and binding assays after inhibition of peptides reveals that dynorphin (1–9) is a potent κ-agonist

1982 • 26 citations

Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18

1987 • 22 citations

K receptor activities of the three opioid peptide families

1983 • 21 citations

Co-localization and characterization of immunoreactive peptides derived from two opioid precursors in guinea pig adrenal glands

1985 • 19 citations

[125I]Dynorphin(1–8) produces a similar pattern of κ-opioid receptor labelling to [3H]dynorphin(1–8) and [3H]etorphine in guinea pig brain: A quantitative autoradiographic study

1988 • 15 citations

Possible mechanism involved in the inhibitory action of U-50, 488H, an opioid .KAPPA. agonist, on guinea pig hippocampal CA3 pyramidal neurons in vitro.

1987 • 14 citations