15 Differential release of classical transmitters and peptides

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

1991 • 1,760 citations

Neuropeptide Y (NPY)‐like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function

1982 • 1,206 citations

Nitric Oxide: A Physiologic Mediator of Penile Erection

1992 • 1,187 citations

Calcium ions, active zones and synaptic transmitter release

1988 • 609 citations

Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin

1985 • 592 citations

Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord.

1988 • 580 citations

Coexistence of peptides and classical neurotransmitters

1983 • 559 citations

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

1993 • 521 citations

Frequency- and reserpine-dependent chemical coding of sympathetic transmission: Differential release of noradrenaline and neuropeptide Y from pig spleen

1986 • 355 citations

Differential release of amino acids, neuropeptides, and catecholamines from isolated nerve terminals

1991 • 330 citations

Co-existence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man

1984 • 260 citations

Stimulation of nitric oxide from muscle cells by VIP: prejunctional enhancement of VIP release

1992 • 258 citations

Exocytosis from large dense cored vesicles outside the active synaptic zones of terminals within the trigeminal subnucleus caudalis: A possible mechanism for neuropeptide release

1986 • 216 citations

Ultrastructural evidence for the coexistence of calcitonin gene-related peptide and substance P in secretory vesicles of peripheral nerves in the guinea pig

1986 • 214 citations

Guanethidine-sensitive release of neuropeptide Y-like immunoreactivity in the cat spleen by sympathetic nerve stimulation

1984 • 193 citations

Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: Importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation and resupply by axonal transport

1989 • 184 citations

Substance P as an excitatory transmitter of primary afferent neurons in guinea-pig sympathetic ganglia

1982 • 176 citations

Effects of the nitric oxide synthase inhibitor N^G‐nitro‐L‐arginine on the erectile response to cavernous nerve stimulation in the rabbit

1991 • 159 citations

Nitric oxide synthase in VIP-containing vasodilator nerve fibres in the Guineapig

1992 • 151 citations

Differential release of calcitonin gene‐related peptide and neuropeptide Y from the isolated heart by capsaicin, ischaemia, nicotine, bradykinin and ouabain

1989 • 135 citations

Neurogenic inflammation in the rat trachea. II. Identity and distribution of nerves mediating the increase in vascular permeability

1988 • 128 citations

Peptidergic and muscarinic excitation at amphibian sympathetic synapses.

1983 • 128 citations

Differential effects of reserpine and 6-hydroxydopamine on neuropeptide Y (NPY) and noradrenaline in peripheral neurons

1985 • 126 citations

Ultrastructural localization of VIP-like immunoreactivity in large dense-core vesicles of ‘cholinergic-type’ nerve terminals in cat exocrine glands

1981 • 120 citations

Subcellular storage and axonal transport of neuropeptide Y (NPY) in relation to catecholamines in the cat

1985 • 118 citations

Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion II. Effects of cholinergic antagonists and VIP antiserum

1981 • 113 citations

Pharmacology of noradrenaline and neuropeptide tyrosine (NPY)‐mediated sympathetic cotransmission

1990 • 103 citations

Characterization and presynaptic modulation of stimulation-evoked exocytotic co-release of noradrenaline and neuropeptide Y in guinea pig heart

2004 • 90 citations

Subcellular fractionation of cat submandibular gland: Comparative studies on the distribution of acetylcholine and vasoactive intestinal polypeptide (VIP)

1981 • 89 citations

Relaxation of sheep cerebral arteries by vasoactive intestinal polypeptide and neurogenic stimulation: inhibition by <scp>l</scp>‐N^G‐monomethyl arginine in endothelium‐denuded vessels

1991 • 82 citations

Evidence for two neuropeptide Y receptors mediating vasoconstriction

1991 • 81 citations

Inhibition of low pH evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist

1992 • 80 citations

Relative involvement of substance P and CGRP mechanisms in antidromic vasodilation in the rat skin

1992 • 79 citations

Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow

1992 • 76 citations

Evidence for co‐transmitter role of neuropeptide Y in the pig spleen

1989 • 70 citations

Nitric oxide‐related vasodilator responses to parasympathetic stimulation of the submandibular gland in the cat.

1993 • 69 citations

Substance P in trigeminal nerve endings: Occurrence and release

1981 • 68 citations

Neuropeptide Y and catecholamine synthesizing enzymes and their mRNAs in rat sympathetic neurons and adrenal glands: Studies on expression, synthesis and axonal transport after pharmacological and experimental manipulations using hybridization techniques and radioimmunoassay

1991 • 67 citations

Capsaicin-induced bronchoconstriction and neuropeptide release in guinea pig perfused lungs

1990 • 65 citations

Cigarette smoke-induced airway oedema is blocked by the NK1 antagonist, CP-96,345

1991 • 60 citations

Neuropeptide Y and noradrenaline mechanisms in relation to reserpine induced impairment of sympathetic neurotransmission in the cat spleen

1987 • 56 citations

Bronchoconstrictor and hypotensive effects in relation to pharmacokinetics of tachykinins in the guinea-pig ?evidence for extraneuronal cleavage of neuropeptide K to neurokinin A

1987 • 55 citations

Effects of autonomic stimulation on the release of vasoactive intestinal peptide from the gastrointestinal tract in the calf

1980 • 54 citations

Capsazepine inhibits low pH- and lactic acid-evoked release of calcitonin gene-related peptide from sensory nerves in guinea-pig heart

1992 • 49 citations

The effect of reserpine on sympathetic, purinergic neurotransmission in the isolated mesenteric artery of the dog: a pharmacological study

1987 • 42 citations

Different ion channel mechanisms between low concentrations of capsaicin and high concentrations of capsaicin and nicotine regarding peptide release from pulmonary afferents

1992 • 41 citations

Pharmacological characterization of neuropeptide Y and noradrenaline mechanisms in sympathetic control of pig spleen

1989 • 40 citations

Sympathetic regulation of skeletal muscle blood flow in the pig: a non‐adrenergic component likely to be mediated by neuropeptide Y

1993 • 39 citations

Reserpine-induced depletion of neuropeptide Y from cardiovascular nerves and adrenal gland due to enhanced release

1986 • 39 citations

Sympathetic vascular control of the pig nasal mucosa (2): reserpine‐resistant, non‐adrenergic nervous responses in relation to neuropeptide Y and ATP

1988 • 37 citations

Nitric oxide regulates peptide release from parasympathetic nerves and vascular reactivity to vasoactive intestinal polypeptide in vivo

1994 • 37 citations

Neuropeptide Y differentiates between exocytotic and nonexocytotic noradrenaline release in guinea-pig heart

1989 • 34 citations

Postjunctional inhibitory effect of the NK₂ receptor antagonist, SR 48968, on sensory NANC bronchoconstriction in the guinea‐pig

1993 • 31 citations

Neuropeptide Y and non-adrenergic sympathetic vascular control of the cat nasal mucosa

1987 • 31 citations

Neuropeptide Y and reserpine‐resistant vasoconstriction evoked by sympathetic nerve stimulation in the dog skeletal muscle

1988 • 31 citations

CP-96,345 antagonism of NK1 receptors and smoke-induced protein extravasation in relation to its cardiovascular effects

1992 • 30 citations

Role of calcium channels and protein kinase C for release of norepinephrine and neuropeptide Y

1990 • 28 citations

Roles of neuropeptide Y and noradrenaline in sympathetic neurotransmission to the thoracic vena cava and aorta of guinea-pigs

1991 • 28 citations

Variable α2-adrenoceptor-mediated inhibition of bronchoconstriction and peptide release upon activation of pulmonary afferents

1992 • 27 citations

Facilitation of the release of noradrenaline and neuropeptide Y by the α2-adrenoceptor blocking agents idazoxan and hydergine in the dog spleen

1988 • 25 citations

NG-monomethyl L-arginine is a non-specific inhibitor of vascular relaxation

1989 • 25 citations

Inhibitory effects of capsazepine and the NK2 antagonist SR 48968 on bronchoconstriction evoked by sensory nerve stimulation in guinea‐pigs

1992 • 23 citations

Neurokinin a in capsaicin-sensitive neurons of the guinea-pig inferior mesenteric ganglia: An additional putative mediator for the non-cholinergic excitatory postsynaptic potential

1987 • 21 citations

Attenuation of long-lasting effects of sympathetic stimulation after repeated stimulation.

1990 • 20 citations

Regulation of neuropeptide release from pulmonary capsaicin-sensitive afferents in relation to bronchoconstriction.

1993 • 20 citations

Renal sympathetic nerve activation in relation to reserpine‐induced depletion of neuropeptide Y in the kidney of the rat

1988 • 19 citations

Nerve-induced nonadrenergic vasoconstriction and vasodilatation in skeletal muscle

1990 • 18 citations

Repeated renal and splenic sympathetic nerve stimulation in anaesthetized pigs: maintained overflow of neuropeptide Y in controls but not after reserpine

1994 • 17 citations

Facilitation by ‘low sodium-urea’ medium of the washout of dopamine β-hydroxylase released by potassium ions from the perfused rabbit heart

1980 • 8 citations

Involvement of tachykinin and CGRP receptors in the cardio-pulmonary effects evoked by capsaicin in the guinea-pig

1993 • 4 citations