Molecular biology of opioid receptors

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

The pharmacological basis of therapeutics

1981 • 2,853 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

The Role of Somatostatin and Its Analogs in the Diagnosis and Treatment of Tumors

1991 • 827 citations

Molecular cloning and functional expression of a mu opioid receptor from rat brain

1994 • 805 citations

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

1994 • 630 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium

1974 • 554 citations

Neurobiology of opiate abuse

1992 • 546 citations

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity

1993 • 546 citations

Peptides Chemistry, Structure and Biology

1990 • 510 citations

Opioid receptor-coupled second messenger systems

1991 • 466 citations

Cloning and pharmacological characterization of a rat μ opioid receptor

1993 • 460 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

1989 • 441 citations

Cloning and pharmacological characterization of a rat kappa opioid receptor.

1993 • 422 citations

mu opiate receptor: cDNA cloning and expression.

1993 • 405 citations

Identification of residues required for ligand binding to the beta-adrenergic receptor.

1987 • 398 citations

Neural substrates of opiate withdrawal

1992 • 361 citations

The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation

1993 • 342 citations

Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype.

1989 • 331 citations

Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.

1991 • 330 citations

Buprenorphine Suppresses Heroin Use by Heroin Addicts

1980 • 302 citations

Primary structures and expression from cDNAs of rat opioid receptor δ‐and μ‐subtypes

1993 • 277 citations

An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.

1990 • 266 citations

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

1987 • 266 citations

Molecular Characterization of Opioid Receptors

1990 • 266 citations

Cloning and expression of a cDNA for the rat k‐opioid receptor

1993 • 234 citations

Expression of Mu opioid receptor mRNA in rat brain: An in situ hybridization study at the single cell level

1994 • 213 citations

Diversity of structure, signaling and regulation within the family of muscarinic cholinergic receptors

1992 • 179 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.

1993 • 146 citations

Opioid Actions on Membrane Ion Channels

1993 • 144 citations

Cellular responses to chronic treatment with drugs of abuse.

1993 • 138 citations

Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

1990 • 135 citations

Opiate antagonistic properties of an octapeptide somatostatin analog.

1982 • 132 citations

Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor

1988 • 128 citations

Opioid receptors and endogenous opioid peptides

1991 • 107 citations

Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity.

1985 • 106 citations

Sodium ion modulates agonist and antagonist interactions with the human platelet alpha 2-adrenergic receptor in membrane and solubilized preparations.

1982 • 101 citations

Alternative splicing generates multiple isoforms of a rabbit prostaglandin E2 receptor.

1994 • 92 citations

Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.

1994 • 87 citations

A selective .delta.1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for .delta.1 opioid receptor agonists and antagonists

1993 • 72 citations

Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.

1994 • 70 citations

Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.

1993 • 64 citations

Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand.

1990 • 62 citations

Cross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes

1991 • 40 citations

Opioid Receptors and their Pharmacological Profiles

1992 • 38 citations

Sodium regulation of agonist and antagonist binding to ?-adrenoceptors in intact and Ns-deficient membranes

1986 • 32 citations

Development of Receptor-Selective Opioid Peptide Analogs as Pharmacologic Tools and as Potential Drugs

1993 • 24 citations

Modulation of Binding at Opioid Receptors by Monoand Divalent Cations and by Cholinergic Compounds

1988 • 22 citations

Selective Nonpeptide Opioid Antagonists

1993 • 13 citations