Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2

Mitochondria and Apoptosis

1998 • 8,909 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca ²⁺ Responses

1998 • 2,130 citations

Calcium - a life and death signal

1998 • 2,040 citations

Calcium signaling

1995 • 1,905 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives

1999 • 1,156 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Mitochondrial Participation in the Intracellular Ca2+ Network

1997 • 556 citations

Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes

1997 • 513 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis

1999 • 352 citations

Mitochondrial Depolarization Accompanies Cytochrome cRelease During Apoptosis in PC6 Cells

1999 • 347 citations

Mitochondrial Ca2+ homeostasis in intact cells.

1994 • 320 citations

The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin.

1994 • 300 citations

Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

1997 • 296 citations

Intracellular Ca2+ Signals Activate Apoptosis in Thymocytes: Studies Using the Ca2+-ATPase Inhibitor Thapsigargin

1994 • 253 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

1996 • 247 citations

Transient Mitochondrial Depolarizations Reflect Focal Sarcoplasmic Reticular Calcium Release in Single Rat Cardiomyocytes

1998 • 242 citations

Physiological role of mitochondrial Ca2+ transport

1994 • 209 citations

Chapter 14 Measurement of Cell Death

1998 • 207 citations

Ca2+ Homeostasis in the Agonist-sensitive Internal Store: Functional Interactions Between Mitochondria and the ER Measured In Situ in Intact Cells

1998 • 185 citations

Modulation of endoplasmic reticulum calcium pump by Bcl-2

1998 • 184 citations

A Role for Calcium Influx in the Regulation of Mitochondrial Calcium in Endothelial Cells

1996 • 183 citations

Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells

1997 • 167 citations

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.

1996 • 164 citations

Changes in membrane potential during calcium ion influx and efflux across the mitochondrial membrane

1978 • 89 citations

Towards the molecular basis for the regulation of mitochondrial dehydrogenases by calcium ions

1995 • 79 citations

Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria.

1984 • 74 citations

Consequences of Functional Expression of the Plasma Membrane Ca2+ Pump Isoform 1a

1996 • 70 citations

A Potent Cell Death Activity Associated with Transient High Level Expression of BCL-2

1998 • 60 citations

Endogenous Bax Translocation in SH‐SY5Y Human Neuroblastoma Cells and Cerebellar Granule Neurons Undergoing Apoptosis

1999 • 60 citations

Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells

1995 • 56 citations

Effects of alterations in calcium homeostasis on apoptosis during neoplastic progression.

1997 • 51 citations

Reduced Capacitative Calcium Entry Correlates with Vesicle Accumulation and Apoptosis

1999 • 38 citations