The Novel Presenilin-1-associated Protein Is a Proapoptotic Mitochondrial Protein

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Caspases: killer proteases

1997 • 2,440 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Apoptotic Pathways

1998 • 1,193 citations

Apoptosis signaling by death receptors

1998 • 976 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis

2000 • 717 citations

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1998 • 641 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

1996 • 424 citations

Mitochondrial carrier proteins

1994 • 337 citations

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

1997 • 321 citations

Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins

1997 • 291 citations

Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch

1999 • 268 citations

REVIEWThe Gene Defects Responsible for Familial Alzheimer's Disease

1996 • 262 citations

Distinct steps in the import of ADP/ATP carrier into mitochondria.

1987 • 248 citations

Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo

1996 • 226 citations

Increased Sensitivity to Mitochondrial Toxin-Induced Apoptosis in Neural Cells Expressing Mutant Presenilin-1 Is Linked to Perturbed Calcium Homeostasis and Enhanced Oxyradical Production

1998 • 222 citations

Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts

1999 • 221 citations

Presenilin-1 Mutation Increases Neuronal Vulnerability to Focal IschemiaIn Vivoand to Hypoxia and Glucose Deprivation in Cell Culture: Involvement of Perturbed Calcium Homeostasis

2000 • 169 citations

Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.

1996 • 167 citations

Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules

2000 • 158 citations

Presenilins and Alzheimer’s disease: biological functions and pathogenic mechanisms

2000 • 152 citations

Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch

2000 • 148 citations

Mutant Presenilin-1 Induces Apoptosis and Downregulates Akt/PKB

1999 • 139 citations

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

2002 • 133 citations

15 Methods for Detecting and Quantifying Apoptosis

1997 • 116 citations

Generation of Anti-apoptotic Presenilin-2 Polypeptides by Alternative Transcription, Proteolysis, and Caspase-3 Cleavage

1997 • 109 citations

Interaction of Alzheimer's Presenilin-1 and Presenilin-2 with Bcl-XL

1999 • 107 citations

Overexpression in Neurons of Human Presenilin-1 or a Presenilin-1 Familial Alzheimer Disease Mutant Does Not Enhance Apoptosis

1998 • 105 citations

Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor Protein

2001 • 103 citations

Stat1-Dependent, p53-Independent Expression of p21^waf1 Modulates Oxysterol-Induced Apoptosis

2002 • 99 citations

Cellular Expression and Proteolytic Processing of Presenilin Proteins Is Developmentally Regulated During Neuronal Differentiation

1997 • 81 citations

Presenilin 1 Protein Directly Interacts with Bcl-2

1999 • 71 citations

Cell surface expression of the Alzheimer disease-related presenilin proteins

1997 • 63 citations

Contrasting Role of Presenilin-1 and Presenilin-2 in Neuronal DifferentiationIn Vitro

1999 • 63 citations

Regulation of Apoptosis by Presenilin 1

1998 • 61 citations

Presenilin-1 is located in rat mitochondria

2002 • 59 citations

Identification of a Novel PSD-95/Dlg/ZO-1 (PDZ)-like Protein Interacting with the C Terminus of Presenilin-1

1999 • 49 citations

The Import Route of ADP/ATP Carrier into Mitochondria Separates from the General Import Pathway of Cleavable Preproteins at thetrans Side of the Outer Membrane

1998 • 45 citations

Simultaneous detection of cyclin B1, p105, and DNA content provides complete cell cycle phase fraction analysis of cells that endoreduplicate

1999 • 32 citations

Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

2002 • 31 citations

Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1

1999 • 29 citations

Overexpression of a C-terminal fragment of Presenilin 1 delays anti-Fas induced apoptosis in Jurkat cells

1999 • 15 citations