Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

1982 • 704 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Vitamin E, Ascorbate, Glutathione, Glutathicne Disulfide, and Enzymes of Glutathione Metabolism in Cultures of Chick Astrocytes and Neurons: Evidence that Astrocytes Play an Important Role in Antioxidative Processes in the Brain

1994 • 413 citations

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

1998 • 382 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

Dihydrorhodamine 123: a fluorescent probe for superoxide generation?

1993 • 349 citations

Morphological and biochemical maturation of neurones cultured in the absence of glial cells

1979 • 325 citations

Cellular reducing equivalents and oxidative stress

1994 • 275 citations

Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson’s disease

1998 • 231 citations

Assessment of the Role of the Glutathione and Pentose Phosphate Pathways in the Protection of Primary Cerebrocortical Cultures from Oxidative Stress

1996 • 187 citations

<scp>l</scp>‐DOPA Up‐Regulates Glutathione and Protects Mesencephalic Cultures Against Oxidative Stress

1996 • 184 citations

Activation of Heat Shock Factor by Alkylating Agents Is Triggered by Glutathione Depletion and Oxidation of Protein Thiols

1996 • 182 citations

Staurosporine Induces Programmed Cell Death in Embryonic Neurons and Activation of the Ceramide Pathway

1996 • 174 citations

Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

1998 • 164 citations

Heat shock protects neuronal cells from programmed cell death by apoptosis

1993 • 161 citations

Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones

1996 • 148 citations

Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion

1998 • 147 citations

Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: Protection with antioxidants and glutamate receptor antagonists

1996 • 139 citations

Ca²⁺ and Reactive Oxygen Species in Staurosporine‐Induced Neuronal Apoptosis

1997 • 126 citations

Glutamate Toxicity on a PC12 Cell Line Involves Glutathione (GSH) Depletion and Oxidative Stress

1997 • 110 citations

Protection from oxidation enhances the survival of cultured mesencephalic neurons

1995 • 55 citations

Retinoic acid reduces staurosporine-induced apoptotic damage in chick embryonic neurons by suppressing reactive oxygen species production

1998 • 38 citations

The Role of Oxidative Stress in Neuronal Death

1997 • 29 citations

A common pathway mediates retinoic acid and PMA-dependent programmed cell death (apoptosis) of neuronal cells

1994 • 29 citations

Characterization and localization of glutathione binding sites on cultured astrocytes

1992 • 25 citations

Inhibition of glutathione synthesis can enhance cycloheximide-induced protection of developing neurons against axotomy

1997 • 18 citations

Oxidative Stress in Neuronal Death and Apoptosis

1997 • 7 citations