Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

1996 • 3,012 citations

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 • 2,762 citations

Neuropathological Classification of Huntingtonʼs Disease

1985 • 2,517 citations

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

1997 • 2,184 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

1998 • 1,592 citations

Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

1997 • 1,283 citations

Huntington Disease

1998 • 1,255 citations

Ataxin-1 Nuclear Localization and Aggregation

1998 • 959 citations

Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3

1997 • 821 citations

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology

1999 • 716 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1997 • 528 citations

Polyglutamine-Expanded Human Huntingtin Transgenes Induce Degeneration of Drosophila Photoreceptor Neurons

1998 • 523 citations

Intranuclear Neuronal Inclusions in Huntington's Disease and Dentatorubral and Pallidoluysian Atrophy: Correlation between the Density of Inclusions andIT15CAG Triplet Repeat Length

1998 • 421 citations

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA

1998 • 401 citations

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch

1998 • 360 citations

Glutamine Repeats and Neurodegenerative Diseases: Molecular Aspects

2002 • 354 citations

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

1995 • 350 citations

Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions

1998 • 338 citations

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

1998 • 328 citations

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

1995 • 221 citations

An Isoform of Ataxin‐3 Accumulates in the Nucleus of Neuronal Cells in Affected Brain Regions of SCA3 Patients

1998 • 205 citations

Morphometric analysis of the prefrontal cortex in Huntington's disease

1991 • 204 citations

Paralimbic frontal lobe hypometabolism in depression associated with Huntington's disease

1992 • 197 citations

DNA Damage Distribution in the Human Brain as Shown by In Situ End Labeling; Area-specific Differences in Aging and Alzheimer Disease in the Absence of Apoptotic Morphology

1997 • 136 citations

The Neuropathology of CAG Repeat Diseases: Review and Update of Genetic and Molecular Features

1997 • 129 citations

Hereditary dentatorubral-pallidoluysian atrophy: detection of widespread ubiquitinated neuronal and glial intranuclear inclusions in the brain

1998 • 94 citations

The cortical neuritic pathology of Huntington's disease

1995 • 89 citations

From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington'sdisease

1999 • 77 citations

Huntington's Disease and Dentatorubral‐Pallidoluysian Atrophy: Proteins, Pathogenesis and Pathology

1997 • 62 citations

Neuronal distribution of intranuclear inclusions in Huntingtonʼs disease with adult onset

1998 • 60 citations

Inherited Neurodegenerative Disorders Caused by CAG/Polyglutamine Tract Expansions: Symposium Introduction

1997 • 8 citations