Role of the Mitochondrial Permeability Transition and Cytochrome c Release in Hydrogen Peroxide-Induced Apoptosis

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

Reactive oxygen species and programmed cell death

1996 • 745 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

[16] Isolation of subcellular organelles

1990 • 563 citations

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

1999 • 449 citations

Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death

1998 • 372 citations

Drug Antioxidant Effects

1991 • 365 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

1999 • 319 citations

BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases

1999 • 314 citations

Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

2000 • 296 citations

Protective Effect of N-Acetylcysteine in Tumor Necrosis Factor-α-Induced Apoptosis in U937 Cells: The Role of Mitochondria

1995 • 274 citations

Damage, Repair, and Mutagenesis in Nuclear Genes after Mouse Forebrain Ischemia–Reperfusion

1996 • 228 citations

Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases

1995 • 224 citations

Cytokine-mediated Induction of Ceramide Production Is Redox-sensitive

1998 • 206 citations

Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation

2000 • 199 citations

Oxidative damage to mitochondria is mediated by the Ca2+-dependent inner-membrane permeability transition

1993 • 151 citations

Nitric Oxide Donors Induce Stress Signaling via Ceramide Formation in Rat Renal Mesangial Cells

1999 • 135 citations

Flow cytometric analysis of the early phases of apoptosis by cellular and nuclear techniques

1996 • 120 citations

Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons.

1997 • 114 citations

DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation.

1995 • 109 citations

Free radicals and pathogenesis during ischemia and reperfusion of the cat small intestine

1994 • 108 citations

Role of small heat shock protein HSP25 in radioresistance and glutathione-redox cycle

2000 • 99 citations

Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium

1987 • 87 citations

Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis

2001 • 77 citations

Role of reactive oxygen intermediates in interleukin 10 release after cold liver ischemia and reperfusion in mice

1997 • 68 citations

Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis

2001 • 64 citations

Blood Cells With Reduced Mitochondrial Membrane Potential and Cytosolic Cytochrome C Can Survive and Maintain Clonogenicity Given Appropriate Signals to Suppress Apoptosis

1998 • 61 citations

Release of cytochrome c from mitochondria to cytosol in gerbil hippocampal CA1 neurons after transient forebrain ischemia

1999 • 43 citations

The role of DNA damage and inhibition of poly(ADP-ribosyl)ation in loss of clonogenicity of murine L929 fibroblasts, caused by photodynamically induced oxidative stress.

1994 • 33 citations

Role of Reactive Oxygen Intermediates in Lipopolysaccharide- Mediated Hepatic Injury in the Rat

1996 • 30 citations

DNA damage induced by tumour necrosis factor-α in L929 cells is mediated by mitochondrial oxygen radical formation

1995 • 8 citations