Does insulin dysfunction play a role in Alzheimer's disease?

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Diabetes mellitus and the risk of dementia

1999 • 2,031 citations

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

2000 • 1,878 citations

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Cerebral microvascular pathology in aging and Alzheimer's disease

2001 • 1,041 citations

The Endocrinology of Aging

1997 • 957 citations

Intraneuronal Aβ42 Accumulation in Human Brain

2000 • 955 citations

Metabolic Regulation of Brain Aβ by Neprilysin

2001 • 918 citations

Cardiovascular risk factors and cognitive decline in middle-aged adults

2001 • 876 citations

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

2000 • 837 citations

Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population

1995 • 814 citations

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

1998 • 783 citations

Cognition and synaptic plasticity in diabetes mellitus

2000 • 765 citations

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

1998 • 728 citations

Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study

1997 • 683 citations

Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort

2001 • 671 citations

Association of diabetes mellitus and dementia: The Rotterdam Study

1996 • 650 citations

Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

2000 • 568 citations

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease

1998 • 550 citations

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

2000 • 550 citations

Recruitment of functional GABAA receptors to postsynaptic domains by insulin

1997 • 531 citations

Alzheimer's disease: A study of epidemiological aspects

1984 • 529 citations

Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

1997 • 517 citations

Brain Insulin Receptors and Spatial Memory

1999 • 516 citations

Memory improvement following induced hyperinsulinemia in alzheimer's disease

1996 • 495 citations

A Portrait of Alzheimer Secretases--New Features and Familiar Faces

2001 • 492 citations

Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats.

1998 • 482 citations

Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

2001 • 479 citations

Insulin receptors and insulin action in the brain: review and clinical implications

2000 • 478 citations

Role of insulin and insulin receptor in learning and memory

2001 • 470 citations

Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

2000 • 466 citations

IRS-2 pathways integrate female reproduction and energy homeostasis

2000 • 459 citations

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study

1997 • 427 citations

PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer

2000 • 389 citations

Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects

1991 • 386 citations

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

1999 • 369 citations

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

1999 • 362 citations

Review of Alterations in Endothelial Nitric Oxide Production in Diabetes

1998 • 357 citations

Intracerebroventricular insulin enhances memory in a passive-avoidance task

2000 • 341 citations

The Insulin Receptor Tyrosine Kinase Substrate p58/53 and the Insulin Receptor Are Components of CNS Synapses

1999 • 326 citations

Improving Influence of Insulin on Cognitive Functions in Humans

2001 • 309 citations

Cognitive effects of insulin in the central nervous system

2001 • 269 citations

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis

1998 • 260 citations

Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo.

2000 • 257 citations

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

2000 • 233 citations

Insulin Transiently Increases Tau Phosphorylation

1999 • 233 citations

Longitudinal association of vascular and Alzheimer's dementias, diabetes, and glucose tolerance

1999 • 227 citations

Intracellular APP Processing and Aβ Production in Alzheimer Disease

1999 • 186 citations

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.

1993 • 179 citations

Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase‐dependent pathway

2000 • 175 citations

Tracking Insulin to the Mind

1998 • 171 citations

Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects

1997 • 166 citations

Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors

2001 • 157 citations

Vascular Risks and Incident Dementia: Results from a Cohort Study of the Very Old

1998 • 156 citations

Insulin Metabolism in Alzheimer’s Disease Differs According to Apolipoprotein E Genotype and Gender

1999 • 151 citations

Endogenous Proteins Controlling Amyloid β-Peptide Polymerization

1999 • 150 citations

Generation and Regulation of β‐Amyloid Peptide Variants by Neurons

1998 • 123 citations

Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion

1997 • 121 citations

Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons

2000 • 119 citations

Low blood pressure and blood glucose levels in Alzheimer's disease Evidence for a hypometabolic disorder?

1993 • 111 citations

Genes, models and Alzheimer's disease

2001 • 108 citations

Insulin Causes a Transient Tyrosine Phosphorylation of NR2A and NR2B NMDA Receptor Subunits in Rat Hippocampus

1999 • 103 citations

Impact of referral bias on clinical and epidemiological studies of Alzheimer's disease

1996 • 99 citations

Moving the insulin-regulated glucose transporter GLUT4 into and out of storage

2001 • 90 citations

Intracellular biology of Alzheimer's disease amyloid beta peptide

1999 • 78 citations

Vascular aspects in Alzheimer’s disease

2000 • 73 citations

Clinical and Epidemiological Aspects of Alzheimer's Disease with Presenile Onset: A Case Control Study

1990 • 73 citations

Dementia and its associations in type 2 diabetes mellitus: The Fremantle Diabetes Study

2001 • 52 citations

The effect of insulin and glucose on the plasma concentration of Alzheimer's amyloid precursor protein

1999 • 46 citations

Analysis of Familial and Individual Risk Factors Among Patients with Ischemic Vascular Dementia and Alzheimer's Disease

1993 • 45 citations

Post-menopausal estrogen deprivation and Alzheimer's disease

2000 • 36 citations

The Export of Major Histocompatibility Complex Class I Molecules from the Endoplasmic Reticulum of Rat Brown Adipose Cells Is Acutely Stimulated by Insulin

2001 • 24 citations

CELLULAR AND MOLECULAR BASIS OF β-AMYLOID PRECURSOR PROTEIN METABOLISM

2000 • 7 citations