Requirement for Superoxide in Excitotoxic Cell Death

Methods of Enzymatic Analysis

1975 • 20,446 citations

Free radicals in biology and medicine

1991 • 17,840 citations

Superoxide Dismutase

1969 • 12,578 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

4 Lactate Dehydrogenase

1975 • 1,272 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase

1970 • 1,037 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Spectrophotometric measurements of the enzymatic formation of fumaric and cis-aconitic acids

1950 • 818 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

1995 • 773 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

1993 • 628 citations

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

1988 • 600 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

Paraquat: model for oxidant-initiated toxicity.

1984 • 556 citations

Superoxide sensitivity of the Escherichia coli aconitase.

1991 • 499 citations

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

1995 • 467 citations

Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.

1994 • 403 citations

The role of iron in the activation-inactivation of aconitase.

1983 • 379 citations

Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical.

1992 • 336 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

1995 • 334 citations

Excitatory amino acids and neuropsychiatrie disorders

1989 • 327 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

Non-NMDA receptor-mediated neurotoxicity in cortical culture

1990 • 291 citations

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

1994 • 291 citations

Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells.

1994 • 271 citations

21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures

1990 • 248 citations

Inciting Excitotoxic Cytocide Among Central Neurons

1986 • 231 citations

Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: Dependence on calcium concentration

1986 • 204 citations

A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro.

1995 • 191 citations

NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes

1992 • 183 citations

Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons

1994 • 103 citations

Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase.

1990 • 103 citations

Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells

1993 • 99 citations

The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase

1952 • 60 citations

Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor.

1995 • 58 citations

Blockade of N-methyl-d-aspartate receptors prevents cyanide-induced neuronal injury in primary hippocampal cultures

1992 • 50 citations

N-methyl-D-aspartate receptors mediate cyanide-induced cytotoxicity in hippocampal cultures.

1993 • 43 citations

A Cationic Manganic Porphyrin Inhibits Uptake of Paraquat by Escherichia coli

1995 • 19 citations