Regulation of BMP and Activin Signaling in Drosophila

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

1997 • 3,802 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Smad regulation in TGF-β signal transduction

2001 • 917 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1999 • 833 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

1999 • 823 citations

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1999 • 788 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

Silencing of TGF-β signalling by the pseudoreceptor BAMBI

1999 • 691 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

1998 • 649 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Cytonemes

1999 • 602 citations

Multiple defects and perinatal death in mice deficient in follistatin

1995 • 586 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

wishful thinking Encodes a BMP Type II Receptor that Regulates Synaptic Growth in Drosophila

2002 • 520 citations

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

2001 • 506 citations

Divergence and convergence of TGF‐β/BMP signaling

2001 • 503 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo

1992 • 480 citations

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

1999 • 474 citations

Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling

2000 • 473 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

1998 • 448 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1997 • 426 citations

TGF-β receptor signaling

1997 • 417 citations

Argosomes

2001 • 413 citations

Hedgehog Creates a Gradient of DPP Activity in Drosophila Wing Imaginal Discs

2000 • 402 citations

Glypicans: proteoglycans with a surprise

2001 • 360 citations

Production of a DPP Activity Gradient in the Early Drosophila Embryo through the Opposing Actions of the SOG and TLD Proteins

1997 • 350 citations

Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

1982 • 345 citations

Mechanism of TGFβ receptor inhibition by FKBP12

1997 • 342 citations

Glypicans: proteoglycans with a surprise

2001 • 337 citations

The Drosophila BMP Type II Receptor Wishful Thinking Regulates Neuromuscular Synapse Morphology and Function

2002 • 330 citations

Ras Pathway Specificity Is Determined by the Integration of Multiple Signal-Activated and Tissue-Restricted Transcription Factors

2000 • 324 citations

TGF-β Family Signal Transduction in Drosophila Development: From Mad to Smads

1999 • 324 citations

Specific Interaction of Type I Receptors of the TGF-β Family with the Immunophilin FKBP-12

1994 • 321 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo

1995 • 312 citations

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

1994 • 307 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

2001 • 304 citations

Twisted gastrulation is a conserved extracellular BMP antagonist

2001 • 302 citations

The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1

1991 • 292 citations

The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.

1987 • 288 citations

An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo

1993 • 283 citations

Transducing the Dpp Morphogen Gradient in the Wing of Drosophila

1999 • 280 citations

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling

2000 • 278 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic

1994 • 275 citations

The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila

1995 • 271 citations

Follistatin: A Multifunctional Regulatory Protein

1998 • 267 citations

The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation

1999 • 262 citations

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor

1994 • 254 citations

The Smad pathway

2000 • 252 citations

TGFβ-related pathways

2000 • 251 citations

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to theDrosophila mesoderm

1998 • 250 citations

dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp

1997 • 241 citations

Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex

1999 • 234 citations

Primary structure of the human follistatin precursor and its genomic organization.

1988 • 234 citations

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes

1999 • 232 citations

TGF-β Signaling Activates Steroid Hormone Receptor Expression during Neuronal Remodeling in the Drosophila Brain

2003 • 230 citations

Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development.

1996 • 226 citations

Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell

1993 • 224 citations

Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo

1992 • 222 citations

Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila

1998 • 218 citations

Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors

1996 • 213 citations

The drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family

1995 • 212 citations

Twisted gastrulation can function as a BMP antagonist

2001 • 202 citations

Molecular organization of the decapentaplegic gene in Drosophila melanogaster.

1990 • 201 citations

schnurri is required for drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1

1995 • 200 citations

The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo.

1994 • 199 citations

Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

2002 • 194 citations

Ski/Sno and TGF-β signaling

2001 • 192 citations

The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

1999 • 190 citations

Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling

2001 • 187 citations

Local inhibition and long-range enhancement of Dpp signal transduction by Sog

1999 • 185 citations

Problems and paradigms: Morphogens and pattern formation

1997 • 184 citations

Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells

1996 • 174 citations

Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems

2002 • 172 citations

The role ofbrinkerin mediating the graded response to Dpp in earlyDrosophilaembryos

1999 • 168 citations

Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway

1997 • 168 citations

Recombinant Expression of Human Follistatin with 315 and 288 Amino Acids: Chemical and Biological Comparison with Native Porcine Follistatin*

1991 • 166 citations

A Novel BMP Expressed in Developing Mouse Limb, Spinal Cord, and Tail Bud Is a Potent Mesoderm Inducer inXenopusEmbryos

1999 • 166 citations

Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila

2000 • 163 citations

Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling

2000 • 161 citations

Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins.

1991 • 159 citations

TGF-β/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing

1998 • 156 citations

Regulatory Principles of Developmental Signaling

2002 • 155 citations

Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses

1998 • 153 citations

Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor.

1994 • 139 citations

The Drosophila saxophone Gene: a Serine-Threonine Kinase Receptor of the TGF-β Superfamily

1994 • 131 citations

Localized expression of a dpp / BMP2 / 4 ortholog in a coral embryo

2002 • 130 citations

Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs

2001 • 128 citations

The p21 ^RAS Farnesyltransferase α Subunit in TGF-β and Activin Signaling

1996 • 128 citations

Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo

2000 • 127 citations

Programmed cell death in the absence of c-Fos and c-Jun

1996 • 127 citations

Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region

2001 • 126 citations

A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling

1995 • 125 citations

Interpretation of a BMP Activity Gradient in Drosophila Embryos Depends on Synergistic Signaling by Two Type I Receptors, SAX and TKV

1998 • 122 citations

The DSmurf Ubiquitin-Protein Ligase Restricts BMP Signaling Spatially and Temporally during Drosophila Embryogenesis

2001 • 119 citations

Schnurri mediates Dpp-dependent repression of brinker transcription

2000 • 119 citations

Morphogen gradients: new insights from DPP

1999 • 116 citations

Bambi is coexpressed with Bmp-4 during mouse embryogenesis

2001 • 114 citations

Identification of a Drosophila activin receptor.

1993 • 114 citations

The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4

1998 • 113 citations

The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling

1998 • 112 citations

Sequence, biochemical characterization, and developmental expression of a new member of the TGF-β superfamily in Drosophila melanogaster

1992 • 111 citations

On the existence of cytokines in invertebrates

2001 • 110 citations

Characterization of differentially expressed genes in purified Drosophila follicle cells: Toward a general strategy for cell type-specific developmental analysis

1999 • 110 citations

Creation of a Sog Morphogen Gradient in the Drosophila Embryo

2002 • 108 citations

Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity

2000 • 103 citations

Spatially Restricted Activation of the SAX Receptor by SCW Modulates DPP/TKV Signaling in Drosophila Dorsal–Ventral Patterning

1998 • 103 citations

Interplay of Signal Mediators of Decapentaplegic (Dpp): Molecular Characterization of Mothers against dpp, Medea, and Daughters against dpp

1998 • 100 citations

A function of CBP as a transcriptional co-activator during Dpp signalling

1999 • 96 citations

PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster

2002 • 94 citations

Sequence and expression of myoglianin, a novel Drosophila gene of the TGF-β superfamily

1999 • 94 citations

Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling

1997 • 89 citations

Context-dependent relationships between the BMPsgbbanddppduring development of theDrosophilawing imaginal disk

2001 • 89 citations

Brinker requires two corepressors for maximal and versatile repression in Dpp signalling

2001 • 85 citations

Genetic Analysis of the Bone Morphogenetic Protein-Related Gene, gbb, Identifies Multiple Requirements During Drosophila Development

1999 • 84 citations

Follistatin-related protein (FSRP): a new member of the follistatin gene family

2001 • 78 citations

Dally-like protein, a new Drosophila glypican with expression overlapping with wingless

2000 • 78 citations

Repression of Dpp Targets by Binding of Brinker to Mad Sites

2001 • 76 citations

Murine Schnurri-2 is required for positive selection of thymocytes

2001 • 72 citations

The Zinc Finger Protein Schnurri Acts as a Smad Partner in Mediating the Transcriptional Response to Decapentaplegic

2000 • 72 citations

Characterization of tolloid-related-1: A BMP-1-like Product That Is Required during Larval and Pupal Stages of Drosophila Development

1994 • 69 citations

A Mammalian Homolog of Drosophila schnurri, KRC, Regulates TNF Receptor-Driven Responses and Interacts with TRAF2

2002 • 65 citations

Zebrafishnma is involved in TGF? family signaling

2000 • 65 citations

TGFβ inhibitors: new and unexpected requirements in vertebrate development

1999 • 63 citations

A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A

1998 • 62 citations

The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila development.

1995 • 53 citations

FKBP12 Is a Negative Regulator of Transforming Growth Factor-β Receptor Internalization

2000 • 52 citations

Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs

1998 • 50 citations

Correction: Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 47 citations

schnurri Is Required for dpp-Dependent Patterning of the Drosophila Wing

2000 • 45 citations

Drosophila dSmad2 and Atr‐I transmit activin/TGFβ signals

1999 • 42 citations

The transcription factor Schnurri plays a dual role in mediating Dpp signaling during embryogenesis

2001 • 41 citations

The Twisted gastrulation family of proteins, together with the IGFBP and CCN families, comprise the TIC superfamily of cysteine rich secreted factors

2001 • 41 citations

Identification of a New Member of Transforming Growth Factor-Beta Superfamily inDrosophila:The First Invertebrate Activin Gene

1998 • 40 citations

Identification of maverick , a novel member of the TGF-β superfamily in Drosophila

2000 • 39 citations

Schnurri interacts with Mad in a Dpp‐dependent manner

2000 • 32 citations

Identification of a NovelDrosophilaSMAD on the X Chromosome

1998 • 28 citations

Xenopus Dan, a member of the Dan gene family of BMP antagonists, is expressed in derivatives of the cranial and trunk neural crest

2001 • 21 citations

Isolation of Drosophila Activin and Follistatin cDNAs using novel MACH amplification protocols

2002 • 16 citations