ROS and p53: A versatile partnership

Free radicals and antioxidants in normal physiological functions and human disease

2006 • 13,251 citations

Free Radicals in the Physiological Control of Cell Function

2002 • 9,561 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

2007 • 3,267 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Cellular response to oxidative stress: Signaling for suicide and survival*

2002 • 2,258 citations

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

2006 • 1,840 citations

p53 Regulates Mitochondrial Respiration

2006 • 1,600 citations

Redefining Oxidative Stress

2006 • 1,587 citations

Post-translational modification of p53 in tumorigenesis

2004 • 1,227 citations

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

2005 • 1,102 citations

The antioxidant function of the p53 tumor suppressor

2005 • 1,072 citations

Death Signal-induced Localization of p53 Protein to Mitochondria

2000 • 883 citations

Regulation of p53 activity through lysine methylation

2004 • 776 citations

Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation

2003 • 708 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

The ubiquitin ligase COP1 is a critical negative regulator of p53

2004 • 693 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

Glycolytic Enzymes Can Modulate Cellular Life Span

2005 • 615 citations

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

2001 • 554 citations

Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity

2004 • 541 citations

microRNAs join the p53 network — another piece in the tumour-suppression puzzle

2007 • 535 citations

Regulation of reactive-oxygen-species generation in fibroblasts by Rac 1

1996 • 488 citations

Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence

2006 • 483 citations

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

2004 • 472 citations

Protein Kinase C ß and Prolyl Isomerase 1 Regulate Mitochondrial Effects of the Life-Span Determinant p66 ^Shc

2007 • 455 citations

Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

1999 • 433 citations

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

2002 • 431 citations

Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells

2001 • 400 citations

Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species ¹

1997 • 392 citations

Glutathionylation of the p50 Subunit of NF-κB: a Mechanism for Redox-Induced Inhibition of DNA Binding

2001 • 384 citations

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

2004 • 374 citations

In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation

2004 • 368 citations

Collateral Damage in Cancer Chemotherapy: Oxidative Stress in Nontargeted Tissues

2007 • 367 citations

Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation

2007 • 347 citations

The p53 tumor suppressor participates in multiple cell cycle checkpoints

2006 • 314 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Functions and Mechanisms of Redox Regulation of Cysteine-Based Phosphatases

2005 • 295 citations

A redox cycle within the cell cycle: ring in the old with the new

2006 • 286 citations

Redox regulation of c‐Jun DNA binding by reversible S‐glutathiolation

1999 • 285 citations

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

2002 • 285 citations

Effect of Extracellular Signal-regulated Kinase on p53 Accumulation in Response to Cisplatin

2000 • 280 citations

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ

2005 • 275 citations

Monoubiquitylation promotes mitochondrial p53 translocation

2007 • 272 citations

p53 Translocation to Mitochondria Precedes Its Nuclear Translocation and Targets Mitochondrial Oxidative Defense Protein-Manganese Superoxide Dismutase

2005 • 239 citations

DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation

2006 • 232 citations

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

2004 • 221 citations

Specificity in reactive oxidant signaling: think globally, act locally

2006 • 209 citations

Mitochondrial defects in cardiomyopathy and neuromuscular disease

2000 • 204 citations

The importance of p53 location: nuclear or cytoplasmic zip code?

2003 • 202 citations

Human p53 Is Inhibited by Glutathionylation of Cysteines Present in the Proximal DNA-Binding Domain during Oxidative Stress^,

2007 • 194 citations

Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

2000 • 194 citations

The effects of superoxide dismutase on H2O2 formation

2007 • 185 citations

Zinc Binding and Redox Control of p53 Structure and Function

2001 • 176 citations

Use and abuse of exogenous H2O2 in studies of signal transduction

2007 • 174 citations

Reciprocal down-regulation of p53 and SOD2 gene expression–implication in p53 mediated apoptosis

2001 • 174 citations

P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA.

2003 • 173 citations

Regulation of AIF expression by p53

2006 • 173 citations

hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes

2007 • 171 citations

Disruption of mitochondrial redox circuitry in oxidative stress

2006 • 169 citations

The p53-induced Gene-6 (Proline Oxidase) Mediates Apoptosis through a Calcineurin-dependent Pathway

2005 • 160 citations

Hzf Determines Cell Survival upon Genotoxic Stress by Modulating p53 Transactivation

2007 • 154 citations

Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer

2004 • 152 citations

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

1994 • 148 citations

Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria

2005 • 139 citations

Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide.

2000 • 129 citations

MDM2-ARF complex regulates p53 sumoylation

2003 • 124 citations

Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity

2005 • 120 citations

PUMA Overexpression Induces Reactive Oxygen Species Generation and Proteasome-Mediated Stathmin Degradation in Colorectal Cancer Cells

2005 • 119 citations

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

2002 • 111 citations

Specificity Protein 1-dependent p53-mediated Suppression of Human Manganese Superoxide Dismutase Gene Expression

2006 • 110 citations

Regulation of the p53 transcriptional activity

2005 • 98 citations

Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin

2004 • 95 citations

Mammalian Antioxidant Defenses Are Not Inducible by H2O2

2004 • 94 citations

Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export

2001 • 90 citations

Formation of Disulfide Bond in p53 Correlates with Inhibition of DNA Binding and Tetramerization

2003 • 86 citations

p53 Is Cleaved by Caspases Generating Fragments Localizing to Mitochondria

2006 • 83 citations

Balance of Yin and Yang: Ubiquitylation-Mediated Regulation of p53 and c-Myc

2006 • 81 citations

C-Myc Down-Regulation Increases Susceptibility to Cisplatin through Reactive Oxygen Species-Mediated Apoptosis in M14 Human Melanoma Cells

2001 • 79 citations

SUMOylation Code in Cancer Development and Metastasis

2006 • 75 citations

Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization

2005 • 69 citations

p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression.

1999 • 69 citations

Mitochondrial and Nuclear p53 Localization in Cardiomyocytes: Redox Modulation by Doxorubicin (Adriamycin)?

2007 • 68 citations

Irradiation-induced Translocation of p53 to Mitochondria in the Absence of Apoptosis

2005 • 53 citations

Protein methylation and DNA repair

2007 • 51 citations

The p53 knowledgebase: an integrated information resource for p53 research

2006 • 48 citations

Glutathionylation of Two Cysteine Residues in Paired Domain Regulates DNABinding Activity ofPax-8

2005 • 37 citations

Airing Out an Antioxidant Role for the Tumor Suppressor p53

2006 • 34 citations