Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

2002 • 1,171 citations

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

2004 • 1,091 citations

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

2002 • 1,071 citations

Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

2004 • 750 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

2002 • 575 citations

Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine

1998 • 444 citations

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

1995 • 430 citations

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

2005 • 418 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease

2003 • 400 citations

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

2003 • 388 citations

Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria

2003 • 376 citations

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

1990 • 323 citations

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism

1999 • 304 citations

MPTP as a Mitochondrial Neurotoxic Model of Parkinson's Disease

2004 • 281 citations

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

1998 • 255 citations

Mitochondria-Targeted Cytoprotective Peptides for Ischemia–Reperfusion Injury

2007 • 254 citations

Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation

1999 • 248 citations

The rotenone model of Parkinson's disease: genes, environment and mitochondria

2003 • 247 citations

Rapid ATP Loss Caused by 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine in Mouse Brain

1991 • 242 citations

Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines

2005 • 234 citations

Neuroprotection and Neuronal Differentiation Studies Using Substantia Nigra Dopaminergic Cells Derived from Transgenic Mouse Embryos

1999 • 196 citations

Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease

2004 • 173 citations

The genetics of Parkinson disease: implications for neurological care

2006 • 166 citations

A Novel Cell-permeable Antioxidant Peptide, SS31, Attenuates Ischemic Brain Injury by Down-regulating CD36

2006 • 164 citations

Cell‐permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

2006 • 160 citations

Minocycline enhances MPTP toxicity to dopaminergic neurons

2003 • 154 citations

Transcellular Transport of a Highly Polar 3+ Net Charge Opioid Tetrapeptide

2003 • 143 citations

Potent mitochondria-targeted peptides reduce myocardial infarction in rats

2007 • 137 citations

Prevention of Mitochondrial Oxidative Damage Using Targeted Antioxidants

2002 • 130 citations

Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain

2005 • 119 citations

MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes

1993 • 106 citations

Effects of 1‐Methyl‐4‐Phenylpyridinium on Isolated Rat Brain Mitochondria: Evidence for a Primary Involvement of Energy Depletion

1994 • 104 citations

Coenzyme Q10 in Neurodegenerative Diseases

2003 • 99 citations

Melatonin protects against MPTP/MPP⁺‐induced mitochondrial DNA oxidative damage in vivo and in vitro

2005 • 92 citations

Additive Neuroprotective Effects of Creatine and a Cyclooxygenase 2 Inhibitor Against Dopamine Depletion in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Mouse Model of Parkinson's Disease

2003 • 83 citations

Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition

1997 • 83 citations

A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities

2004 • 44 citations

Do Mitochondriotropic Antioxidants Prevent Chlorinative Stress-Induced Mitochondrial and Cellular Injury?

2007 • 44 citations

Differential Involvement of Mitochondrial Permeability Transition in Cytotoxicity of 1-Methyl-4-Phenylpyridinium and 6-Hydroxydopamine

2006 • 30 citations

Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria

2003 • 30 citations

Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline

2004 • 28 citations

Anaerobic Glycolysis Protection against 1-Methy-4-Phenylpyridinium (MPP+) Toxicity in C6 Glioma Cells

2007 • 23 citations

Azulenyl Nitrone Spin Traps Protect against MPTP Neurotoxicity

1998 • 22 citations

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