Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

2005 • 2,025 citations

International Trial of the Edmonton Protocol for Islet Transplantation

2006 • 1,869 citations

Reactive species mechanisms of cellular hypoxia-reoxygenation injury

2002 • 1,014 citations

Flow cytometry of apoptotic cell death

2000 • 764 citations

Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

2004 • 750 citations

Coenzyme Q ₁₀ administration increases brain mitochondrial concentrations and exerts neuroprotective effects

1998 • 546 citations

Mitochondrial regulation of apoptotic cell death

2004 • 474 citations

Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function

1996 • 459 citations

Selective targeting of an antioxidant to mitochondria

1999 • 443 citations

Targeting antioxidants to mitochondria: A new therapeutic direction

2005 • 397 citations

Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria

2003 • 376 citations

VARIABLES IN ORGAN DONORS THAT AFFECT THE RECOVERY OF HUMAN ISLETS OF LANGERHANS1

1996 • 306 citations

Cell-permeable, mitochondrial-targeted, peptide antioxidants

2006 • 298 citations

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

2000 • 286 citations

Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment

2004 • 277 citations

Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines

2005 • 234 citations

The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice

2003 • 213 citations

Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat

1998 • 195 citations

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

2004 • 179 citations

Cell‐permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

2006 • 160 citations

Synthesis and in vitro opioid activity profiles of DALDA analogues

2000 • 157 citations

Transcellular Transport of a Highly Polar 3+ Net Charge Opioid Tetrapeptide

2003 • 143 citations

ENDOTOXIN-MEDIATED DELAYED ISLET GRAFT FUNCTION IS ASSOCIATED WITH INCREASED INTRA-ISLET CYTOKINE PRODUCTION AND ISLET CELL APOPTOSIS1

2001 • 138 citations

Potent mitochondria-targeted peptides reduce myocardial infarction in rats

2007 • 137 citations

Interventional Strategies to Prevent β-Cell Apoptosis in Islet Transplantation

2006 • 137 citations

Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes

2003 • 118 citations

XIAP Overexpression in Human Islets Prevents Early Posttransplant Apoptosis and Reduces the Islet Mass Needed to Treat Diabetes

2005 • 111 citations

Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function

2005 • 107 citations

Genetic Engineering of a Suboptimal Islet Graft with A20 Preserves β Cell Mass and Function

2003 • 106 citations

Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background.

1990 • 92 citations

THE CORRELATION BETWEEN DONOR CHARACTERISTICS AND THE SUCCESS OF HUMAN ISLET ISOLATION1,2

1994 • 92 citations

N-Acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria

1995 • 86 citations

SERINE-PROTEASE INHIBITION DURING ISLET ISOLATION INCREASES ISLET YIELD FROM HUMAN PANCREASES WITH PROLONGED ISCHEMIA1

2001 • 75 citations

EARLY ASSESSMENT OF APOPTOSIS IN ISOLATED ISLETS OF LANGERHANS1

2001 • 70 citations

The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts

2005 • 68 citations

Comparison of [Dmt¹]DALDA and DAMGO in Binding and G Protein Activation at μ, δ, and κ Opioid Receptors

2003 • 60 citations

Proapoptotic bax is hyperexpressed in isolated human islets compared with antiapoptotic bcl-21

2002 • 47 citations

Intra‐Ductal Glutamine Administration Reduces Oxidative Injury During Human Pancreatic Islet Isolation

2005 • 42 citations

Pancreas preservation by the 2-layer cold storage method before islet isolation protects isolated islets against apoptosis through the mitochondrial pathway

2003 • 40 citations

Enforced c-REL deficiency prolongs survival of islet allografts1

2002 • 33 citations

Insulin-Induced Normoglycemia Reduces Islet Number Needed to Achieve Normoglycemia after Allogeneic Islet Transplantation in Diabetic Mice

2003 • 22 citations

The Fate of Pancreatic Islets Transplanted into Diabetic Mice Is Dependent on Their Genetic Background

1990 • 20 citations