Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

1996 • 3,012 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

1997 • 866 citations

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

1997 • 792 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

2000 • 550 citations

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene

1998 • 509 citations

Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1

2000 • 375 citations

Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide

1995 • 369 citations

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse

2000 • 341 citations

Increased oxidative damage to DNA in ALS patients

2000 • 316 citations

Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions

1991 • 240 citations

Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex

1999 • 207 citations

The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids

1999 • 193 citations

A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods

1999 • 181 citations

The Active Site of ICP47, a Herpes Simplex Virus–encoded Inhibitor of the Major Histocompatibility Complex (MHC)-encoded Peptide Transporter Associated with Antigen Processing (TAP), Maps to the NH2-terminal 35 Residues

1997 • 169 citations

Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington’s disease

2000 • 132 citations

Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and γ-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases

1985 • 131 citations

No Evidence for Increased Oxidative Damage to Lipids, Proteins, or DNA in Huntington's Disease

2000 • 49 citations

Intranuclear Distribution of 8-hydroxy-2'-deoxyguanosine: An Immunocytochemical Study

1999 • 38 citations