The antioxidant function of the p53 tumor suppressor

Free Radicals in the Physiological Control of Cell Function

2002 • 9,561 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

2004 • 1,241 citations

Oxidative Decay of DNA

1997 • 938 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

1996 • 851 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

1999 • 792 citations

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

2003 • 756 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

2001 • 624 citations

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

2004 • 374 citations

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1994 • 346 citations

Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions

2003 • 322 citations

Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA

1988 • 275 citations

Transcriptional Activation of the Human Glutathione Peroxidase Promoter by p53

1999 • 254 citations

Effects of genetic background on tumorigenesis in p53‐deficient mice

1995 • 252 citations

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

1999 • 241 citations

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

2004 • 221 citations

Genomic instability and apoptosis are frequent in p53 deficient young mice

1997 • 197 citations

p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells.

1995 • 190 citations

MDM2 Gene Amplification and Transcript Levels in Human Sarcomas: Relationship to TP53 Gene Status

1994 • 188 citations

Role of p53 in Sensing Oxidative DNA Damage in Response to Reactive Oxygen Species-Generating Agents

2004 • 182 citations

Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.

1996 • 171 citations

Modulation of redox-sensitive transcription factors by calorie restriction during aging

2002 • 164 citations

Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice.

1994 • 161 citations

Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice

2004 • 138 citations

Recommendations on Predictive Testing for Germ Line p53 Mutations Among Cancer-Prone Individuals

1992 • 129 citations

Effect of N -Acetyl Cysteine on Oxidative DNA Damage and the Frequency of DNA Deletions in Atm -Deficient Mice

2004 • 129 citations

Maintaining genetic stability through TP53 mediated checkpoint control.

1997 • 117 citations

A mutational assay system for L5178Y mouse lymphoma cells, using hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT) -deficiency as marker. The occurrence of a long expression time for mutations induced by X-rays and EMS

1975 • 114 citations

Induction by carcinogens and chemoprevention by N-acetylcysteine of adducts to mitochondrial DNA in rat organs.

1996 • 89 citations

Absence of p53 permits propagation of mutant cells following genotoxic damage

1997 • 77 citations

The role of p53 in base excision repair following genotoxic stress

2003 • 69 citations

Chromosome changes caused by alterations of p53 expression

1996 • 57 citations

Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development.

2003 • 56 citations

The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)

2004 • 51 citations

Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8

2000 • 31 citations

Diet-Gene Interactions in p53-Deficient Mice: Insulin-like Growth Factor-1 as a Mechanistic Target

2004 • 31 citations

[Effect of on various cell lines of p53 cDNA, expressed under the control of an exogenous homologous promotor].

1995 • 1 citations