Oxidative Stress Involvement inα-Synuclein Oligomerization in Parkinson's Disease Cybrids

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Diagnostic Criteria for Parkinson Disease

1999 • 2,780 citations

[37] Carbonyl assays for determination of oxidatively modified proteins

1994 • 2,605 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Glutathione, oxidative stress and neurodegeneration

2000 • 1,188 citations

ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATION

1985 • 840 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

Dityrosine Cross-linking Promotes Formation of Stable α-Synuclein Polymers

2000 • 561 citations

Neuropathology, biochemistry, and biophysics of α‐synuclein aggregation

2007 • 524 citations

Oxidative stress and inflammation in Parkinson's disease: is there a causal link?

2005 • 490 citations

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1998 • 440 citations

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1999 • 421 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

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2005 • 363 citations

Platelet mitochondria function in Parkinson's disease

1992 • 350 citations

Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells

1985 • 348 citations

Coenzyme Q₁₀ levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

1997 • 321 citations

Antioxidant compounds have potent anti‐fibrillogenic and fibril‐destabilizing effects for α‐synuclein fibrils in vitro

2006 • 306 citations

Widespread Alterations of α-Synuclein in Multiple System Atrophy

1999 • 296 citations

Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system

1995 • 284 citations

High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function.

1990 • 283 citations

The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer’s and Parkinson’s diseases1,2 11Guest Editors: Mark A. Smith and George Perry 22This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 277 citations

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease

1991 • 269 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1997 • 266 citations

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

1997 • 263 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1998 • 260 citations

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity

2004 • 256 citations

α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

2006 • 200 citations

Tubulin Seeds α-Synuclein Fibril Formation

2002 • 193 citations

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2001 • 185 citations

Cell systems and the toxic mechanism(s) of α-synuclein

2007 • 173 citations

Neuronal Death and Survival Under Oxidative Stress in Alzheimer and Parkinson Diseases

2007 • 138 citations

Metal ions and oxidative protein modification in neurological disease.

2005 • 134 citations

Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies

2004 • 122 citations

Oxidative stress‐induced phosphorylation, degradation and aggregation of α‐synuclein are linked to upregulated CK2 and cathepsin D

2007 • 115 citations

Mitochondrial function in Parkinson’s disease cybrids containing an nt2 neuron-like nuclear background

2008 • 108 citations

Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients

2004 • 80 citations

The parkinsonism producing neurotoxin MPP⁺ affects microtubule dynamics by acting as a destabilising factor

2005 • 74 citations

Rotenone selectively kills serotonergic neurons through a microtubule‐dependent mechanism

2007 • 61 citations

Neurodegenerative Pathways in Parkinsons Disease: Therapeutic Strategies

2005 • 54 citations

Differential Cytotoxicity of Human Wild Type and Mutant α-Synuclein in Human Neuroblastoma SH-SY5Y Cells in the Presence of Dopamine

2004 • 47 citations

Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.

2003 • 39 citations

Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease

2008 • 39 citations

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2007 • 35 citations

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2003 • 34 citations