An attempt to prevent senescence: A mitochondrial approach

Aging: A Theory Based on Free Radical and Radiation Chemistry

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Oxygen-Derived Free Radicals in Postischemic Tissue Injury

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Premature ageing in mice expressing defective mitochondrial DNA polymerase

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Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention

2007 • 2,208 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

2005 • 2,025 citations

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

1997 • 1,695 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Radical causes of cancer

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Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Reactive Oxygen Species (Ros-Induced) Ros Release

2000 • 1,324 citations

The antioxidant function of the p53 tumor suppressor

2005 • 1,072 citations

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

2006 • 1,058 citations

Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

2001 • 1,025 citations

Gain of function mutations in p53

1993 • 876 citations

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

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The signaling mechanism of ROS in tumor progression

2006 • 730 citations

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

1996 • 699 citations

Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences

2006 • 664 citations

Targeting an antioxidant to mitochondria decreases cardiac ischemia‐reperfusion injury

2005 • 581 citations

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

2004 • 560 citations

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

2007 • 542 citations

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

2000 • 536 citations

Demography of Dietary Restriction and Death in Drosophila

2003 • 531 citations

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 • 529 citations

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

1993 • 484 citations

Reactive Oxygen Species Regulate Angiogenesis and Tumor Growth through Vascular Endothelial Growth Factor

2007 • 476 citations

Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria

1969 • 458 citations

Regulation of angiogenesis by hypoxia-inducible factor 1

2006 • 457 citations

Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation

1991 • 449 citations

Selective targeting of an antioxidant to mitochondria

1999 • 443 citations

The Naked Mole-Rat: A New Long-Living Model for Human Aging Research

2005 • 443 citations

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration

2007 • 432 citations

Antioxidants reduce cone cell death in a model of retinitis pigmentosa

2006 • 398 citations

Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors

2007 • 388 citations

Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart

2001 • 369 citations

Topics in current genetics

2003 • 359 citations

Mitochondria‐targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants

2003 • 349 citations

Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species

2005 • 344 citations

High oxidative damage levels in the longest‐living rodent, the naked mole‐rat

2006 • 342 citations

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

2005 • 338 citations

Accumulation of memory T cells from childhood to old age: Central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory cells in CD8+ compartment

2005 • 334 citations

Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models

2006 • 333 citations

Conversion of biomembrane-produced energy into electric form. I. Submitochondrial particles

1970 • 321 citations

Feeding acetyl- <scp>l</scp> -carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

2002 • 315 citations

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies

2008 • 309 citations

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission

2006 • 294 citations

Programmed and altruistic ageing

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Mitochondria and Cancer: Warburg Addressed

2005 • 278 citations

Oncogenic Ras and its role in tumor cell invasion and metastasis

2004 • 266 citations

Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms

1999 • 266 citations

Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms

2007 • 257 citations

Conversion of biomembrane-produced energy into electric form. II. Intact mitochondria

1970 • 250 citations

Luminol Luminescence Induced by 2,2′-Azo-Bis(2-Amidinopropane) Thermolysis

1992 • 249 citations

Mitochondrial Free Radical Production and Aging in Mammals and Birds^a

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Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways

2007 • 239 citations

Mitochondrial respiratory chain and free radical generation in stroke

2005 • 235 citations

Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa

2007 • 229 citations

A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet

2003 • 228 citations

SOD2 Knockdown Mouse Model of Early AMD

2007 • 222 citations

Mitochondria-derived Reactive Oxygen Species Mediate Blue Light–induced Death of Retinal Pigment Epithelial Cells¶

2004 • 221 citations

Glaucoma ocular Alzheimer s disease

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Cardiolipin Switch in Mitochondria: Shutting off the Reduction of Cytochrome c and Turning on the Peroxidase Activity

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MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

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Conversion of biomembrane-produced energy into electric form. IV. General discussion

1970 • 193 citations

The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney

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A biochemical approach to the problem of aging: “Megaproject” on membrane-penetrating ions. The first results and prospects

2007 • 183 citations

Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber)

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The Redox Regulation of Thiol Dependent Signaling Pathways in Cancer

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Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

1995 • 170 citations

Mitochondrial Redox Cycling of Mitoquinone Leads to Superoxide Production and Cellular Apoptosis

2007 • 167 citations

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke)

2008 • 165 citations

A causal link between respiration and senescence in Podospora anserina

2000 • 164 citations

Multiple and Additive Functions of ALDH3A1 and ALDH1A1

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Involvement of reactive oxygen species in kidney damage

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Cytoplasmic p21Cip1 Is Involved in Ras-induced Inhibition of the ROCK/LIMK/Cofilin Pathway

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Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat

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Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis

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Mitochondrial physiology and pathology

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Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis

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Phenoptosis: Programmed Death of an Organism

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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals

2008 • 140 citations

A Fluorometric Method for Measurement of Peroxyl Radical Scavenging Activities of Lipophilic Antioxidants

1998 • 140 citations

The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster

2006 • 140 citations

Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability

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Prevention of Mitochondrial Oxidative Damage Using Targeted Antioxidants

2002 • 130 citations

Disparate patterns of age‐related changes in lipid peroxidation in long‐lived naked mole‐rats and shorter‐lived mice

2006 • 125 citations

Fibroblasts From Naked Mole-Rats Are Resistant to Multiple Forms of Cell Injury, But Sensitive to Peroxide, Ultraviolet Light, and Endoplasmic Reticulum Stress

2008 • 119 citations

Reactive Oxygen and Targeted Antioxidant Administration in Endothelial Cell Mitochondria

2006 • 116 citations

Mitochondria in the Programmed Death Phenomena; A Principle of Biology: “It Is Better to Die than to be Wrong”

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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

2008 • 110 citations

Membrane bioenergetics

1989 • 110 citations

Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats

2005 • 109 citations

Synthesis and Characterization of Thiobutyltriphenylphosphonium Bromide, a Novel Thiol Reagent Targeted to the Mitochondrial Matrix

1995 • 106 citations

Mitochondrial “swirls” induced by oxygen stress and in theDrosophilamutanthyperswirl

2004 • 103 citations

p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway

2008 • 101 citations

Comparison of endothelial function, O₂⁻· and H₂O₂ production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice

2006 • 100 citations

Aging as a Mitochondria‐Mediated Atavistic Program: Can Aging Be Switched Off?

2005 • 93 citations

Immunity and ageing in man: Annual review 2006/2007

2007 • 93 citations

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells

2008 • 86 citations

The Free Radical Fantasy

2006 • 85 citations

Versatile functions of p53 protein in multicellular organisms

2007 • 84 citations

Protective Effects of Mitochondria-Targeted Antioxidant SkQ in Aqueous and Lipid Membrane Environments

2008 • 82 citations

Substituted p‐hydroquinones as a chain‐breaking antioxidant during the oxidation of styrene

2002 • 80 citations

How to Clean the Dirtiest Place in the Cell: Cationic Antioxidants as Intramitochondrial ROS Scavengers

2005 • 79 citations

Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing

2005 • 78 citations

ROS up-regulation mediates Ras-induced changes of cell morphology and motility

2006 • 77 citations

Aging, evolvability, and the individual benefit requirement; medical implications of aging theory controversies

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The electromechanical model for energy coupling in mitochondria

1974 • 76 citations

The ROS-NOX Connection in Cancer and Angiogenesis

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25 Years of p53 Research

2005 • 68 citations

The non‐existent aging program: how does it work?

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Plastoquinol and α-tocopherol quinol are more active than ubiquinol and α-tocopherol in inhibition of lipid peroxidation

1997 • 64 citations

Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV‐irradiation: Protective effects of SkQ1, lithium ions and insulin

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Postconditioning is an effective strategy to reduce renal ischaemia/reperfusion injury

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Inhibition of electron transfer from ferrocytochrome b to ubiquinone, cytochrome c1 and duroquinone by antimycin

1975 • 60 citations

Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis

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Substituted p-hydroquinones as inhibitors of lipid peroxidation

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Programmed death as a therapeutic target to reduce myocardial infarction

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Protection against Oxidant-Induced Apoptosis by Exogenous Glutathione in Leber Hereditary Optic Neuropathy Cybrids

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Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms

2005 • 54 citations

Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC

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Participation of ATP/ADP antiporter in oleate- and oleate hydroperoxide-induced uncoupling suppressed by GDP and carboxyatractylate

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Programmed ageing: the theory of maximal metabolic scope

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Enzymology of Ubiquinone‐Utilizing Electron Transfer Complexes in Nonionic Detergent

1979 • 47 citations

Kinetic Analysis of Permeation of Mitochondria-Targeted Antioxidants Across Bilayer Lipid Membranes

2008 • 47 citations

N‐ t ‐Butyl hydroxylamine is an antioxidant that reverses age‐related changes in mitochondria in vivo and in vitro

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Glucose-induced cataract in CuZn-SOD null lenses: An effect of nitric oxide?

2007 • 41 citations

Development of behavioural dysfunctions in accelerated-senescence OXYS rats is associated with early postnatal alterations in brain phosphate metabolism

2005 • 38 citations

In vitro and in vivo studies of the effect of vitamin E on microsomal cytochrome P450 in rat liver

1991 • 37 citations

Aging and the programmed death phenomena

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A New Model of Localized Ischemia in Rat Somatosensory Cortex Produced by Cortical Compression

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Anion permeation limits the uncoupling activity of fatty acids in mitochondria

1992 • 30 citations

Effect of substituents of the benzoquinone ring on electron-transfer activities of ubiquinone derivatives

1990 • 27 citations

The effect of ring substituents on the mechanism of interaction of exogenous quinones with the mitochondrial respiratory chain

1986 • 22 citations

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1970 • 22 citations

Podospora anserina does not senesce when serially passaged in liquid culture

1987 • 19 citations

Suppression of S Antigen-Induced Uveitis by Vitamin E Supplementation

1991 • 17 citations

Analysis of p53 Gene Alterations in Cancer: A Critical View

2007 • 12 citations

Sex, kings and serial killers and other group-selected human traits

2000 • 11 citations

Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection

2007 • 10 citations

Genome instability and oncogenesis

2007 • 10 citations

Age as a Determinant Factor for Endotoxin Induced Uveitis

2006 • 10 citations

Effects of MitoQ and Sod2 on Rates of Retinal Degeneration in Rd1, Atrd1, Rho–/– and Rds Mutant Mice

2006 • 5 citations