Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

1994 • 1,512 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

2000 • 1,411 citations

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

1999 • 1,233 citations

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

2002 • 1,186 citations

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

2001 • 1,085 citations

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁ gene

1996 • 1,027 citations

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains ofHelicobacter pyloriand prevents benzo[a]pyrene-induced stomach tumors

2002 • 774 citations

An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen

2001 • 745 citations

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

2001 • 721 citations

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

1996 • 634 citations

GLUTATHIONE S-TRANSFERASES: GENE STRUCTURE, REGULATION, AND BIOLOGICAL FUNCTION

1989 • 624 citations

Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2

1999 • 584 citations

Nrf2 is essential for protection against acute pulmonary injury in mice

1999 • 572 citations

Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter

2002 • 564 citations

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

1998 • 553 citations

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

2000 • 515 citations

Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers

1988 • 498 citations

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

2001 • 482 citations

Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein

2001 • 454 citations

Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence

1997 • 442 citations

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

2002 • 428 citations

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

1990 • 422 citations

Ferritin and the response to oxidative stress

2001 • 410 citations

Mechanism of Heme Oxygenase-1 Gene Activation by Cadmium in MCF-7 Mammary Epithelial Cells

2000 • 406 citations

Nrf2 Transcription Factor, a Novel Target of Keratinocyte Growth Factor Action Which Regulates Gene Expression and Inflammation in the Healing Skin Wound

2002 • 392 citations

Transcriptional Regulation of the Antioxidant Response Element

2000 • 364 citations

Regulatory mechanisms of cellular response to oxidative stress

1999 • 340 citations

Ferritin and the response to oxidative stress

2001 • 339 citations

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

2000 • 317 citations

Hemin-induced Activation of the Thioredoxin Gene by Nrf2

2001 • 299 citations

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

2001 • 289 citations

The world according to Maf

1997 • 285 citations

Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals

1999 • 278 citations

Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity

1998 • 262 citations

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

2000 • 259 citations

Astrocytes protect neurons from nitric oxide toxicity by a glutathione‐dependent mechanism

2001 • 244 citations

Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells

2001 • 229 citations

Small Maf (MafG and MafK) Proteins Negatively Regulate Antioxidant Response Element-mediated Expression and Antioxidant Induction of the NAD(P)H:Quinone Oxidoreductase1 Gene

2000 • 205 citations

Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species

1999 • 204 citations

Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 Cells

2002 • 193 citations

Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells.

1995 • 161 citations

Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice

2002 • 159 citations

The Rat Quinone Reductase Antioxidant Response Element

1995 • 153 citations

Activation of Endogenous Antioxidant Defenses in Neuronal Cells Prevents Free Radical‐Mediated Damage

1998 • 131 citations

hMAF, a Small Human Transcription Factor That Heterodimerizes Specifically with Nrf1 and Nrf2

1997 • 124 citations

Nrf2-Dependent Activation of the Antioxidant Responsive Element by tert-Butylhydroquinone Is Independent of Oxidative Stress in IMR-32 Human Neuroblastoma Cells

2001 • 122 citations

Activation of Phosphatidylinositol 3-Kinase and Akt bytert-Butylhydroquinone Is Responsible for Antioxidant Response Element-Mediated rGSTA2 Induction in H4IIE Cells

2001 • 114 citations

Astrocyte-Enhanced Neuronal Survival is Mediated by Scavenging of Extracellular Reactive Oxygen Species

1998 • 107 citations

Site-directed mutagenesis of cysteine to serine in the DNA binding regionof Nrf2 decreases its capacity to upregulate antioxidant responseelement-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

2002 • 98 citations

Regulation of rat glutathione S-transferase Ya subunit gene expression. DNA-protein interaction at the antioxidant responsive element.

1992 • 96 citations

Pharmacology and Toxicology of Astrocyte-Neuron Glutamate Transport and Cycling

2002 • 93 citations

Activation of Antioxidant/Electrophile-Responsive Elements in IMR-32 Human Neuroblastoma Cells

1999 • 80 citations

Enhanced NAD(P)H:Quinone Reductase Activity Prevents Glutamate Toxicity Produced by Oxidative Stress

1991 • 80 citations

c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction

2002 • 76 citations

Neuron-astrocyte interactions: implications for cellular energetics and antioxidant levels.

2000 • 73 citations

Genomic Organization of the Genes Gtf2ird1, Gtf2i, and Ncf1 at the Mouse Chromosome 5 Region Syntenic to the Human Chromosome 7q11.23 Williams Syndrome Critical Region

2002 • 42 citations

Platelet‐activating factor induces cell death in cultured astrocytes and oligodendrocytes: Involvement of caspase‐3

2002 • 41 citations

Time-dependent changes in ARE-driven gene expression by use of a noise-filtering process for microarray data

2002 • 29 citations

A CCAAT/enhancer-binding protein site within antioxidant/electrophile response element along with CREB-binding protein participate in the negative regulation of rat GST-Ya gene in vascular smooth muscle cells.

2000 • 23 citations

A CCAAT/Enhancer-binding Protein Site within Antioxidant/Electrophile Response Element Along with CREB-binding Protein Participate in the Negative Regulation of RatGST-Ya Gene in Vascular Smooth Muscle Cells

2000 • 18 citations