Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

2002 • 2,037 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

2002 • 1,510 citations

IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

2002 • 1,401 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

2002 • 1,238 citations

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

2001 • 1,215 citations

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

2000 • 1,191 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

A Critical Role for IL-21 in Regulating Immunoglobulin Production

2002 • 955 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

1998 • 775 citations

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 • 743 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

1996 • 690 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

2002 • 633 citations

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1995 • 619 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

Dendritic cell lineage, plasticity and cross-regulation

2001 • 613 citations

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

2001 • 535 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

2001 • 497 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

2002 • 476 citations

IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation

2002 • 470 citations

Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production

1998 • 458 citations

IFN-γ production by antigen-presenting cells: mechanisms emerge

2001 • 456 citations

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.

1998 • 450 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

2000 • 412 citations

WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection

2001 • 409 citations

IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination

2002 • 395 citations

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

2000 • 394 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

2002 • 382 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

1995 • 350 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

Th2 Lineage Commitment and Efficient IL-4 Production Involves Extended Demethylation of the IL-4 Gene

2002 • 328 citations

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

1996 • 327 citations

Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation

2002 • 326 citations

Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain

2000 • 322 citations

Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression

2002 • 318 citations

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

1991 • 316 citations

Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice

1998 • 314 citations

The biology of Stat4 and Stat6

2000 • 310 citations

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

1994 • 309 citations

Epstein–Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

1997 • 308 citations

Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction

2002 • 304 citations

c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

1998 • 303 citations

Interleukin-12 Is Essential for a Protective Th1 Response in Mice Infected withCryptococcus neoformans

1998 • 303 citations

Ectopic Expression of Activated Stat6 Induces the Expression of Th2-Specific Cytokines and Transcription Factors in Developing Th1 Cells

1999 • 300 citations

The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs

1998 • 300 citations

Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion

2001 • 281 citations

IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

1998 • 274 citations

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.

1997 • 273 citations

The Maf transcription factors: regulators of differentiation

1997 • 272 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells

2002 • 269 citations

Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile

2000 • 252 citations

Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1

2002 • 250 citations

IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response

2002 • 248 citations

SAP controls T cell responses to virus and terminal differentiation of TH2 cells

2001 • 242 citations

Transcription

2002 • 241 citations

IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells

2002 • 240 citations

Treatment of Allergic Airway Inflammation and Hyperresponsiveness by Antisense-Induced Local Blockade of Gata-3 Expression

2001 • 239 citations

Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level

2001 • 234 citations

Embryonic expression and cloning of the murine GATA-3 gene

1994 • 233 citations

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1998 • 228 citations

Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cε transcription of IL-4–stimulated B cells

2002 • 218 citations

Th1 and Th2 cells

2001 • 217 citations

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor.

1997 • 211 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

Gene expression of the GATA-3 transcription factor is increased in atopic asthma

1999 • 204 citations

Gene Silencing Quantitatively Controls the Function of a Developmental trans-Activator

2002 • 204 citations

STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

2002 • 202 citations

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

1999 • 201 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Helper T cells regulate type-2 innate immunity in vivo

2002 • 195 citations

Inducible Expression of Stat4 in Dendritic Cells and Macrophages and Its Critical Role in Innate and Adaptive Immune Responses

2001 • 187 citations

Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation

2001 • 182 citations

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.

1991 • 178 citations

Mutation of Tec family kinases alters T helper cell differentiation

2001 • 174 citations

GATA-3 Significantly Downregulates IFN-γ Production from Developing Th1 Cells in Addition to Inducing IL-4 and IL-5 Levels

1999 • 172 citations

The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease

1998 • 165 citations

Activated STAT4 Has an Essential Role in Th1 Differentiation and Proliferation That Is Independent of Its Role in the Maintenance of IL-12Rβ2 Chain Expression and Signaling

2002 • 162 citations

IL-12 Receptor β2 (IL-12Rβ2)-Deficient Mice Are Defective in IL-12-Mediated Signaling Despite the Presence of High Affinity IL-12 Binding Sites

2000 • 161 citations

NFATc2 and NFATc3 regulate TH2 differentiation and modulate TCR-responsiveness of naïve TH cells

2001 • 158 citations

Cloning and characterization of a mouse IL-12 receptor-beta component.

1995 • 155 citations

The Cell Type-Specific Expression of the Murine IL-13 Gene Is Regulated by GATA-3

2001 • 152 citations

Cutting Edge: Chromatin Remodeling at the IL-4/IL-13 Intergenic Regulatory Region for Th2-Specific Cytokine Gene Cluster

2000 • 152 citations

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6

1998 • 148 citations

T helper subset development: roles of instruction, selection, and transcription

2002 • 147 citations

Regulation of the IL‐12/IL‐12R axis: a critical step in T‐helper cell differentiation and effector function

1999 • 146 citations

Differential Associations between the Cytoplasmic Regions of the Interleukin-12 Receptor Subunits β1 and β2 and JAK Kinases

1997 • 142 citations

The Functional Synergy Between IL-12 and IL-2 Involves p38 Mitogen-Activated Protein Kinase and Is Associated with the Augmentation of STAT Serine Phosphorylation

1999 • 142 citations

Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo.

1999 • 140 citations

ROG, Repressor of GATA, Regulates the Expression of Cytokine Genes

2000 • 139 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

Stat Proteins Control Lymphocyte Proliferation by Regulating p27^Kip1 Expression

1998 • 133 citations

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

2000 • 122 citations

The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-γ Expression

2000 • 118 citations

A 3′ Enhancer in the IL-4 Gene Regulates Cytokine Production by Th2 Cells and Mast Cells

2002 • 117 citations

Regulation of Th2 Cell Differentiation by mel-18, a Mammalian Polycomb Group Gene

2001 • 115 citations

Stat4 Regulates Multiple Components of IFN-γ-Inducing Signaling Pathways

2000 • 114 citations

An Instructive Component in T Helper Cell Type 2 (Th2) Development Mediated by Gata-3

2001 • 111 citations

Interleukin-12: Basic Principles and Clinical Applications

1999 • 111 citations

Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

1998 • 110 citations

Positive Regulatory Role of IL-12 in Macrophages and Modulation by IFN-γ

2001 • 110 citations

Triggering of T cell proliferation through CD28 induces GATA‐3 and promotes T helper type 2 differentiationin vitroandin vivo

1999 • 108 citations

Characterization of cis-Regulatory Elements and Nuclear Factors Conferring Th2-Specific Expression of the IL-5 Gene: A Role for a GATA-Binding Protein

1998 • 107 citations

Inherited disorders of IL-12- and IFNγ-mediated immunity: a molecular genetics update

2002 • 99 citations

Regulation of Interleukin (Il)-18 Receptor α Chain Expression on Cd4+ T Cells during T Helper (Th)1/Th2 Differentiation

2001 • 97 citations

Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiationin vitro andin vivo

1999 • 95 citations

Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells

2001 • 86 citations

Identification of IL-4 promoter elements conferring Th2-restricted expression during T helper cell subset development.

1997 • 83 citations

Th1 Cells Regulate Hematopoietic Progenitor Cell Homeostasis by Production of Oncostatin M

2002 • 82 citations

Structure and Specificity of GATA Proteins in Th2 Development

2001 • 81 citations

Interferon γ Stabilizes the T Helper Cell Type 1 Phenotype

2001 • 79 citations

Molecular events involved in regulating human interferon-gamma gene expression during T cell activation.

1987 • 78 citations

Murine and Human T-Lymphocyte GATA-3 Factors Mediate Transcription through a cis-Regulatory Element within the Human T-Cell Receptor δ Gene Enhancer

1991 • 75 citations

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

2002 • 74 citations

Cell Division Is Not a “Clock” Measuring Acquisition of Competence to Produce IFN-γ or IL-4

2001 • 74 citations

An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex

2001 • 72 citations

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice

2002 • 70 citations

Cutting Edge: Differential Requirements for Stat4 in Expression of Glycosyltransferases Responsible for Selectin Ligand Formation in Th1 Cells

2001 • 66 citations

IL-12, STAT4-Dependent Up-Regulation of CD4+ T Cell Core 2 β-1,6-n-Acetylglucosaminyltransferase, an Enzyme Essential for Biosynthesis of P-Selectin Ligands

2001 • 66 citations

T Helper Type 2 Cell Differentiation Occurs in the Presence of Interleukin 12 Receptor β2 Chain Expression and Signaling

2000 • 63 citations

Lineage commitment in lymphocytes: controlling the immune response.

2001 • 61 citations

The intensity of T cell receptor engagement determines the cytokine pattern of human allergen‐specific T helper cells

1997 • 61 citations

IL-23: A Cytokine That Acts on Memory T Cells

2002 • 60 citations

Friend of GATA Is Expressed in Naive Th Cells and Functions As a Repressor of GATA-3-Mediated Th2 Cell Development

2002 • 53 citations

Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99.

1997 • 50 citations

Cutting Edge: Distal Regulatory Elements Are Required to Achieve Selective Expression of IFN-γ in Th1/Tc1 Effector Cells

2002 • 50 citations

Reduced IFNγ production in response to IL‐12 stimulation and/or reduced IL‐12 production in atopic patients

2000 • 41 citations

Transcriptional Regulation of GATA-3 by an Intronic Regulatory Region and Fetal Liver Zinc Finger Protein 1

2002 • 41 citations

BALB/c Mice Bearing a Transgenic IL-12 Receptor β2 Gene Exhibit a Nonhealing Phenotype toLeishmania majorInfection Despite Intact IL-12 Signaling

2001 • 38 citations

A Mandatory Role for STAT4 in IL-12 Induction of Mouse T Cell CCR5

2001 • 35 citations

Cutting Edge: CD94/NKG2 Is Expressed on Th1 But Not Th2 Cells and Costimulates Th1 Effector Functions

2002 • 31 citations

GATA Elements Are Necessary for the Activity and Tissue Specificity of the T-Cell Receptor Beta-Chain Transcriptional Enhancer

1994 • 31 citations

Atopy and mutations of IL‐12 receptor β2 chain gene

2001 • 18 citations

Deleted Work

1955 • 0 citations