Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Airway remodeling in asthma

1999 • 708 citations

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

1999 • 642 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells.

1998 • 296 citations

Die and Let Live: Eliminating Dangerous Lymphocytes

1996 • 242 citations

Cutting Edge: IL-4-Independent Induction of Airway Hyperresponsiveness by Th2, But Not Th1, Cells

1998 • 234 citations

Contribution of Nitric Oxide Synthases 1, 2, and 3 to Airway Hyperresponsiveness and Inflammation in a Murine Model of Asthma

1999 • 216 citations

Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice.

1996 • 207 citations

MOUSE MODELS OF AIRWAY RESPONSIVENESS: Physiological Basis of Observed Outcomes and Analysis of Selected Examples Using These Outcome Indicators

1999 • 134 citations

Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells

1999 • 123 citations

Th-2 cytokines in allergic disease

2000 • 99 citations

T-box family reunion

1997 • 44 citations