Treatment of Allergic Airway Inflammation and Hyperresponsiveness by Antisense-Induced Local Blockade of Gata-3 Expression

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

1997 • 1,294 citations

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo

2000 • 1,255 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1995 • 619 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

The epidemic of allergy and asthma

1999 • 597 citations

Attenuation of allergic airway inflammation in IL‐4 deficient mice

1994 • 433 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

Requirement for IL-13 independently of IL-4 in experimental asthma

1999 • 350 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

The importance of leukotrienes in airway inflammation in a mouse model of asthma.

1996 • 312 citations

Ectopic Expression of Activated Stat6 Induces the Expression of Th2-Specific Cytokines and Transcription Factors in Developing Th1 Cells

1999 • 300 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation

1999 • 285 citations

Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice

1995 • 275 citations

Th1- and Th2-Type Cytokines Regulate the Expression and Production of Eotaxin and RANTES by Human Lung Fibroblasts

1999 • 235 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

Gene expression of the GATA-3 transcription factor is increased in atopic asthma

1999 • 204 citations

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

1999 • 201 citations

Molecular pathology of allergic disease

2000 • 198 citations

Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF- plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens.

1999 • 178 citations

GATA-3 Significantly Downregulates IFN-γ Production from Developing Th1 Cells in Addition to Inducing IL-4 and IL-5 Levels

1999 • 172 citations

Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.

1997 • 171 citations

Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation

1998 • 158 citations

Molecular pathology of allergic disease

2000 • 156 citations

Glucocorticoids decrease tissue mast cell number by reducing the production of the c-kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems.

1997 • 154 citations

The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12.

1998 • 151 citations

Cutting Edge: Chronic Intestinal Inflammation in STAT-4 Transgenic Mice: Characterization of Disease and Adoptive Transfer by TNF- Plus IFN-γ-Producing CD4+ T Cells That Respond to Bacterial Antigens

1999 • 143 citations

The B cell-specific transcription factor BSAP regulates B cell proliferation.

1994 • 140 citations

ROG, Repressor of GATA, Regulates the Expression of Cytokine Genes

2000 • 139 citations

T Cells and Chronic Asthma

1999 • 127 citations

Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells

1999 • 123 citations

T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice

1997 • 116 citations

The IL-4 Rapidly Produced in BALB/c Mice After Infection with Leishmania major Down-Regulates IL-12 Receptor β2-Chain Expression on CD4+ T Cells Resulting in a State of Unresponsiveness to IL-12

1998 • 112 citations

Triggering of T cell proliferation through CD28 induces GATA‐3 and promotes T helper type 2 differentiationin vitroandin vivo

1999 • 108 citations

Characterization of cis-Regulatory Elements and Nuclear Factors Conferring Th2-Specific Expression of the IL-5 Gene: A Role for a GATA-Binding Protein

1998 • 107 citations

Regulation of the Human Interleukin-5 Promoter by Ets Transcription Factors

1999 • 100 citations

Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiationin vitro andin vivo

1999 • 95 citations

Effect of Inhaled Interleukin-4 on Airway Hyperreactivity in Asthmatics

1998 • 91 citations

Sequential Development of Airway Hyperresponsiveness and Acute Airway Obstruction in a Mouse Model of Allergic Inflammation

2000 • 85 citations

The N-terminal fingers of chicken GATA-2 and GATA-3 are independent sequence-specific DNA binding domains

1997 • 82 citations

STAT6 deficiency in a mouse model of allergen‐induced airways inflammation abolishes eosinophilia but induces infiltration of CD8⁺ T cells

1999 • 77 citations

Eosinophil Development and Bone Marrow and Tissue Eosinophils in Atopic Asthma

1999 • 43 citations

Inhibition of interleukin‐5 with a monoclonal antibody attenuates allergic inflammation

1997 • 37 citations

Multiple Transcription Factors Are Required for Activation of Human Interleukin 9 Gene in T Cells

1996 • 33 citations

Essential Role of T Lymphocytes in the Development of Allergen-Driven Airway Hyperresponsiveness

1998 • 22 citations

Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of T cell resistance against apoptosis

2000 • 13 citations

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