WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses

1998 • 918 citations

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

1997 • 696 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Tumor necrosis factor-α

1991 • 508 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

2000 • 394 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Regulation and biological function of helminth-induced cytokine responses

1991 • 260 citations

Cytokine Receptors and Signal Transduction

1997 • 259 citations

T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.

1992 • 256 citations

Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response.

1995 • 242 citations

Pleiotropy and redundancy: T cell-derived lymphokines in the immune response

1989 • 228 citations

Th1 and Th2 cells

2001 • 217 citations

Interleukin-12 in infectious diseases

1997 • 214 citations

IL-12 Is Required to Maintain a Th1 Response DuringLeishmania majorInfection

2000 • 207 citations

Detection of Weak Estrogenic Flavonoids Using a Recombinant Yeast Strain and a Modified MCF7 Cell Proliferation Assay

1998 • 205 citations

Cloning and Characterization of a Novel Class I Cytokine Receptor

1998 • 140 citations

The integrity of the conserved ‘WS motif’ common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction.

1991 • 130 citations

Regulation of interleukin‐12 receptor β1 chain expression and interleukin‐12 binding by human peripheral blood mononuclear cells

1997 • 102 citations

Common Cytokine Receptor γ chain (γ_c)‐Dependent Cytokines: Understanding in vivo Functions by Gene Targeting

1995 • 81 citations

Tumor Necrosis Factor-Alpha: Central Regulatory Cytokine in the Induction of Macrophage Antimicrobial Activities

1991 • 81 citations

Molecular structure of the IL‐3, GM‐CSF and IL‐5 receptors

1992 • 51 citations

Role of Macrophages in Acute Murine Cytomegalovirus Infection

1998 • 39 citations

Induction of apoptosis of T cells by infecting mice with murine cytomegalovirus

1995 • 28 citations

Analysis of the role of CD4+ T-cells during murine cytomegalovirus infection in different strains of mice

1995 • 18 citations