Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

2000 • 1,191 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

1992 • 697 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Lineage commitment in the immune system: the T helper lymphocyte grows up

2000 • 627 citations

QUANTIFICATION OF MURINE CYTOKINE mRNAs USING REAL TIME QUANTITATIVE REVERSE TRANSCRIPTASE PCR

1999 • 567 citations

Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

2001 • 535 citations

IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation

2002 • 470 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression

2000 • 383 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 343 citations

Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain

2000 • 322 citations

The biology of Stat4 and Stat6

2000 • 310 citations

CD4+ regulatory T cells

2001 • 241 citations

IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

2001 • 237 citations

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor.

1997 • 211 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Inducible Expression of Stat4 in Dendritic Cells and Macrophages and Its Critical Role in Innate and Adaptive Immune Responses

2001 • 187 citations

GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells

2001 • 161 citations

TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression

2000 • 158 citations

The effect of TGF-β1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells

2000 • 154 citations

Gene Microarrays Reveal Extensive Differential Gene Expression in Both CD4+ and CD8+ Type 1 and Type 2 T Cells

2001 • 135 citations

Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation

1997 • 133 citations

Cytokines: IL-21 joins the γc-dependent network?

2001 • 57 citations

Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation

2001 • 40 citations

Proteasome- and p53-dependent Masking of Signal Transducer and Activator of Transcription (STAT) Factors

1997 • 37 citations