Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1997 • 38,984 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymerase.

1991 • 2,688 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

1998 • 785 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

1997 • 696 citations

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

1996 • 690 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Touring protein fold space with Dali/FSSP

1998 • 669 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

1997 • 531 citations

NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility.

1998 • 504 citations

[9] Profile analysis

1990 • 486 citations

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

1999 • 456 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Epstein–Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

1997 • 308 citations

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

1994 • 305 citations

Interleukin-12 Is Essential for a Protective Th1 Response in Mice Infected withCryptococcus neoformans

1998 • 303 citations

IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice.

1998 • 256 citations

A receptor for interleukin 10 is related to interferon receptors.

1993 • 233 citations

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor.

1997 • 211 citations

IL-12, But Not IFN-γ, Plays a Major Role in Sustaining the Chronic Phase of Colitis in IL-10-Deficient Mice

1998 • 201 citations

IL-12 gene therapy protects mice in lethal Klebsiella pneumonia.

1996 • 185 citations

Structural comparisons among the short-chain helical cytokines

1994 • 161 citations

Cloning and characterization of a mouse IL-12 receptor-beta component.

1995 • 155 citations

Interleukin‐12 Antagonist Activity of Mouse Interleukin‐12 p40 Homodimer in Vitro and in Vivo

1996 • 140 citations

New experimental approaches in retrovirus-mediated expression screening.

1998 • 127 citations

Biosynthesis and Posttranslational Regulation of Human IL-12

2000 • 103 citations

IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes

1999 • 97 citations

Interleukin-12 is indispensable for protective immunity against Leishmania major

1997 • 85 citations

Biological function and distribution of human interleukin‐12 receptor β chain

1996 • 83 citations

Chronic Colitis in IL-10^-/-Mice: Insufficient Counter Regulation of a Th1 Response

2000 • 81 citations

Proteolytic cleavage of phospholipase C–γ1 during apoptosis in Molt–4 cells

2000 • 76 citations

Identification of a STAT4 Binding Site in the Interleukin-12 Receptor Required for Signaling

1999 • 65 citations

Construction and Biological Characterization of an Interleukin-12 Fusion Protein (Flexi-12): Delivery to Acute Myeloid Leukemic Blasts Using Adeno-Associated Virus

1997 • 63 citations

Cutting Edge: Ectopic Expression of the IL-12 Receptor-β2 in Developing and Committed Th2 Cells Does Not Affect the Production of IL-4 or Induce the Production of IFN-γ

2000 • 48 citations

HNMP-1: A Novel Hematopoietic and Neural Membrane Protein Differentially Regulated in Neural Development and Injury

1997 • 45 citations

Targeting IL-12, the Key Cytokine Driving Th1-Mediated Autoimmune Diseases

1997 • 33 citations

Molecular Biology of lnterleukin‐12 Receptors

1996 • 23 citations

Evidence for Multiple Sites of Interaction between IL‐12 and Its Receptor

1996 • 18 citations

Structure of the Mouse IL‐12R01 Chain and Regulation of Its Expression in BCG/LPS‐Treated Mice

1996 • 12 citations