Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

2002 • 1,238 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

1998 • 785 citations

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

1998 • 479 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis

2000 • 424 citations

Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4⁺T cells via CD40 ligand

1997 • 313 citations

IFN-γ Shapes Immune Invasion of the Central Nervous System Via Regulation of Chemokines

2000 • 306 citations

Interleukin-12 Is Essential for a Protective Th1 Response in Mice Infected withCryptococcus neoformans

1998 • 303 citations

Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present

2002 • 300 citations

Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death

2001 • 293 citations

In vivo production and function of IL-12 p40 homodimers.

1997 • 231 citations

A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection

2001 • 226 citations

Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy.

1998 • 222 citations

The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System

2001 • 215 citations

Tumor Necrosis Factor α and Lymphotoxin α Are Not Required for Induction of Acute Experimental Autoimmune Encephalomyelitis

1997 • 197 citations

Interleukin‐12 Antagonist Activity of Mouse Interleukin‐12 p40 Homodimer in Vitro and in Vivo

1996 • 140 citations

Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

1998 • 110 citations

Interferon β in multiple sclerosis: is IL-12 suppression the key?

2000 • 99 citations

Interleukin-12, a key cytokine in Th1-mediated autoimmune diseases

1999 • 76 citations

Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock

1997 • 75 citations

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

2002 • 74 citations

Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS

2001 • 59 citations

The critical role of IL-12 and the IL-12R?2 subunit in the generation of pathogenic autoreactive Th1 cells

1999 • 56 citations

Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits

1999 • 53 citations