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1996 • 2,665 citations

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1996 • 2,623 citations

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1993 • 2,546 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

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1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

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1997 • 1,961 citations

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1997 • 1,768 citations

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1998 • 1,651 citations

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1994 • 1,549 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

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1998 • 1,241 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

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1996 • 1,166 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

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1995 • 1,139 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

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1992 • 1,048 citations

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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1994 • 806 citations

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1995 • 800 citations

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1997 • 625 citations

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1994 • 577 citations

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1992 • 510 citations

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1995 • 467 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

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1993 • 457 citations

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1995 • 398 citations

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1994 • 389 citations

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Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

1994 • 320 citations

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1994 • 320 citations

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1997 • 308 citations

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

1995 • 293 citations

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1996 • 243 citations

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1996 • 238 citations

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1994 • 238 citations

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1999 • 237 citations

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1997 • 237 citations

Increased Apoptosis of T Cell Subsets in Aging Humans: Altered Expression of Fas (CD95), Fas Ligand, Bcl-2, and Bax

1998 • 231 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

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Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses.

1990 • 215 citations

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1993 • 189 citations

Endogenous inhibitors of caspases.

1999 • 183 citations

Role of mitochondria and C‐terminal membrane anchor of Bcl‐2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae

1996 • 178 citations

Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.

1997 • 177 citations

Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type I TNF receptor during activation of resting and effector T cells.

1991 • 174 citations

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]

1994 • 174 citations

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

1993 • 168 citations

Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

1996 • 165 citations

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1992 • 155 citations

Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

1995 • 151 citations

Implication of mitochondria in apoptosis

1997 • 135 citations

Characterization of human Fas gene. Exon/intron organization and promoter region.

1995 • 130 citations

Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes

1994 • 129 citations

Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation.

1993 • 113 citations

Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer

1994 • 111 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

Bcl-2 Prevents CD95 (Fas/APO-1)-induced Degradation of Lamin B and Poly(ADP-ribose) Polymerase and Restores the NF-κB Signaling Pathway

1996 • 107 citations

A naturally occurring soluble isoform of murine Fas generated by alternative splicing.

1995 • 93 citations

Increased apoptosis of CD45RO− T cells with aging

1997 • 92 citations

Fas ligand, death gene

1999 • 90 citations

Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors

1997 • 84 citations

Age‐associated changes in mitogen‐induced protein phosphorylation in murine T lymphocytes

1992 • 82 citations

Apoptosis regulated by a death factor and its receptor: Fas ligand and Fas

1994 • 80 citations

Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence

1996 • 78 citations

Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program.

1995 • 72 citations

Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli

1992 • 67 citations

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1999 • 65 citations

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1993 • 63 citations

Increased activity of caspase 3 and caspase 8 in anti-Fas-induced apoptosis in lymphocytes from ageing humans

1999 • 62 citations

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1992 • 57 citations

Mitochondria and apoptosis: HQ or high-security prison?

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Membrane Signal Transduction in T Cells in Aging Humans^a

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Early Steps in T Cell Development Are Affected by Aging

1997 • 49 citations

The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells.

1997 • 49 citations

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1995 • 48 citations

Anti‐CD3‐Induced Apoptosis in T‐Cells From Young and Old Mice

1995 • 46 citations

L-selectin expression differentiates T cells isolated from different lymphoid tissues in cattle but does not correlate with memory.

1992 • 46 citations

IgE regulation and lymphokine patterns in aging humans

1992 • 45 citations

Natural Regulators of T-Cell Lymphokine Production In Vivo

1992 • 45 citations

Regulation of CD95 (APO-1) Expression and the Induction of Apoptosis in Human T Cells: Changes in Old Age

1996 • 42 citations

The Large Subunit of the DNA Replication Complex C (DSEB/RF-C140) Cleaved and Inactivated by Caspase-3 (CPP32/YAMA) during Fas-induced Apoptosis

1997 • 37 citations

Cellular Determinants of Age-related Decrements in the T-cell Mitogen Response of B6CBAF1 Mice

1992 • 34 citations

Age-related impairment of early and late events of signal transduction in mouse immune cells

1993 • 32 citations

Suicide by order: Some open questions about the cell-killing activities of the TNF ligand and receptor families

1996 • 30 citations

An Age-Related Decrease in Rescue from T Cell Death Following Costimulation Mediated by CD28

1996 • 26 citations

Induction of genes during apoptosis: examples from the immune system

1995 • 20 citations

Comparison of CD3 and CD2 activation pathways in T cells from young and elderly adults

1992 • 17 citations

T Cell Differentiation and Functional Maturation in Aging Mice

1993 • 13 citations

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1992 • 12 citations

The Production of TNF, IL-1 And IL-6 in Cutaneous Tissues During Maturation and Aging

1995 • 8 citations

Higher Production of Tumor Necrosis Factor (TNF) Elicited by a Biological Response Modifier (BRM) in Aging Mice.

1993 • 3 citations