IgE regulation and lymphokine patterns in aging humans

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Allergy: Principles and Practice.

1991 • 1,717 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 • 939 citations

Flow-cytometry and sorting

1980 • 875 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

Admission criteria for immunogerontological studies in man: The senieur protocol

1984 • 754 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

Flow Cytometry and Sorting

1991 • 669 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

Distribution of IgE in a community population sample: correlations with age, sex, and allergen skin test reactivity

1981 • 340 citations

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 • 331 citations

The Cellular and Subcellular Bases of Immunosenescence

1989 • 326 citations

Pgp‐1^hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

1989 • 279 citations

Allergy: Principles and Practice

1989 • 276 citations

Interleukin 5 enhances interleukin 4‐induced IgE production by normal human B cells. The role of soluble CD23 antigen

1988 • 265 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

Functional subsets of allergen-reactive human CD4+ T cells

1991 • 244 citations

Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.

1989 • 228 citations

Endogenous interleukin 6 plays an obligatory role in interleukin 4‐dependent human IgE synthesis

1989 • 221 citations

Age-related changes in human lymphocyte subsets: Progressive reduction of the CD4 CD45R (suppressor inducer) population

1988 • 220 citations

Necessity of the assessment of health status in human immunogerontological studies: Evaluation of the senieur protocol

1990 • 183 citations

Production of lymphokine mRNA by CD45R+ and CD45R- helper T cells from human peripheral blood and by human CD4+ T cell clones.

1989 • 169 citations

Age‐related changes in lymphokine production related to a decreased number of CD45RB^hi CD4⁺ T cells

1991 • 154 citations

Restricted production of interleukin 4 by activated human T cells.

1988 • 141 citations

Prostaglandin E2 promotes IL-4-induced IgE and IgG1 synthesis.

1990 • 136 citations

Allergen skin-test reactivity in a community population sample: correlation with age, histamine skin reactions, and total serum immunoglobulin E

1981 • 135 citations

Diminished calcium influx in lectin‐stimulated T cells from old mice

1987 • 133 citations

Functional heterogeneity among human inducer T cell clones.

1988 • 131 citations

Comparison of diversity and function of house dust mite‐specific T lymphocyte clones from atopic and non‐atopic donors

1990 • 113 citations

Regulation of IgE synthesis in humans: A tale of two signals

1991 • 103 citations

A genetic-epidemiologic study of human immune responsiveness to allergens in an industrial population II. The associations among skin sensitivity, total serum IgE, age, sex, and the reporting of allergies in a stratified random sample

1984 • 96 citations

Memory T lymphocyte hyporesponsiveness to non‐cognate stimuli: a key factor in age‐related immunodeficiency

1992 • 95 citations

Noncognate contact-dependent B cell activation can promote IL-4-dependent in vitro human IgE synthesis.

1990 • 87 citations

Immunodeficiency of aging: restorative effects of phorbol ester combined with calcium ionophore.

1986 • 87 citations

Mitogenic lectins bind to the antigen receptor on human lymphocytes

1989 • 83 citations

The Cell Biology of Aging: Immunological Models

1989 • 80 citations

Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation.

1989 • 66 citations

Accumulation of hyporesponsive, calcium extruding memory T cells as a key feature of age-dependent immune dysfunction

1991 • 54 citations

Atopy in infancy and early childhood: Natural history and role of skin testing

1985 • 50 citations

A Genetic-Epidemiologic Study of Human Immune Responsiveness to Allergens in an Industrial Population

1986 • 48 citations

Regulation of germ-line epsilon transcription and induction of epsilon switching in cloned EBV-transformed and malignant human B cell lines by cytokines and CD4+ T cells.

1992 • 45 citations

T lymphocyte heterogeneity in old and young mice: functional defects in T cells selected for poor calcium signal generation

1989 • 44 citations

Lymphokine profile in bone marrow transplant recipients

1991 • 33 citations

Immunoregulatory functions of paf-acether. VIII. Inhibition of IL-4-induced human IgE synthesis in vitro.

1992 • 23 citations

Lymphokine profile in bone marrow transplant recipients

1991 • 21 citations

Deleted Work

1955 • 0 citations