Parkinson's Disease

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

1988 • 3,339 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

A Drosophila model of Parkinson's disease

2000 • 2,062 citations

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system

1970 • 1,980 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

Aggresomes, inclusion bodies and protein aggregation

2000 • 1,881 citations

Reversal of Experimental Parkinsonism by Lesions of the Subthalamic Nucleus

1990 • 1,875 citations

Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease

1998 • 1,826 citations

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

2000 • 1,729 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

The substantia nigra of the human brain

1999 • 1,598 citations

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

1998 • 1,592 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1988 • 1,518 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

2000 • 1,497 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1968 • 1,419 citations

Association between Early-Onset Parkinson's Disease and Mutations in theParkinGene

2000 • 1,398 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Alpha-synuclein and neurodegenerative diseases

2001 • 1,339 citations

Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

2003 • 1,275 citations

Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease

2000 • 1,255 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1988 • 1,235 citations

Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

2002 • 1,220 citations

Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

2002 • 1,179 citations

Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

2002 • 1,152 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct

2001 • 1,116 citations

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones.

1978 • 1,073 citations

Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 • 1,067 citations

Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. Wright

2001 • 1,048 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

2001 • 1,036 citations

Cellular Defenses against Unfolded Proteins

2001 • 979 citations

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

2000 • 975 citations

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1999 • 967 citations

Functional recovery in parkinsonian monkeys treated with GDNF

1996 • 955 citations

An alternative, nonapoptotic form of programmed cell death

2000 • 930 citations

Parkinson Disease in Twins<SUBTITLE>An Etiologic Study</SUBTITLE>

1999 • 861 citations

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

1998 • 859 citations

Biochemical pathophysiology of Parkinson's disease.

1987 • 844 citations

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70

1999 • 830 citations

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

2000 • 830 citations

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch

1995 • 826 citations

Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein

2002 • 817 citations

Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

2002 • 804 citations

α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils

2002 • 795 citations

Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat

1994 • 786 citations

A meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease

2002 • 775 citations

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

1984 • 772 citations

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

2002 • 768 citations

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

2002 • 760 citations

Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

2001 • 738 citations

Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons

2000 • 724 citations

Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

2002 • 722 citations

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease

2000 • 682 citations

Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease

2001 • 675 citations

The Herbicide Paraquat Causes Up-regulation and Aggregation of α-Synuclein in Mice

2002 • 644 citations

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

2002 • 642 citations

Axonal Self-Destruction and Neurodegeneration

2002 • 632 citations

EPIDEMIOLOGY OF PARKINSON'S DISEASE

1996 • 631 citations

Origin and functional consequences of the complex I defect in Parkinson's disease

1996 • 629 citations

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

2003 • 611 citations

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1995 • 608 citations

Environmental risk factors and Parkinson's disease

1997 • 605 citations

Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr α‐synuclein mutation

2001 • 593 citations

Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System

2002 • 577 citations

AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

2002 • 575 citations

Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death

2001 • 570 citations

Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP

2002 • 569 citations

Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome

2000 • 560 citations

Parkin Protects against the Toxicity Associated with Mutant α-Synuclein

2002 • 552 citations

The substantia nigra of the human brain

1999 • 551 citations

Rate of cell death in parkinsonism indicates active neuropathological process

1988 • 545 citations

Targeting programmed cell death in neurodegenerative diseases

2003 • 535 citations

α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

2002 • 511 citations

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

1999 • 510 citations

Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation

1998 • 510 citations

Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice

1999 • 507 citations

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1999 • 505 citations

Neuropathology in mice expressing human alpha-synuclein.

2000 • 499 citations

Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization

1980 • 498 citations

Neurodegenerative Diseases

1994 • 492 citations

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

2001 • 490 citations

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

2001 • 489 citations

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

2002 • 463 citations

The Nigrostriatal Dopaminergic System as a Preferential Target of Repeated Exposures to Combined Paraquat and Maneb: Implications for Parkinson's Disease

2000 • 462 citations

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1997 • 460 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1992 • 457 citations

Neuropathology in Mice Expressing Human α-Synuclein

2000 • 456 citations

Direct binding and functional coupling of α-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis

2001 • 445 citations

Environmental Risk Factors and Parkinson's Disease: A Metaanalysis

2001 • 435 citations

Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by instrastriatal injection of 6-hydroxydopamine

1995 • 435 citations

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

1997 • 420 citations

Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss

1999 • 416 citations

Aggregated and Monomeric α-Synuclein Bind to the S6′ Proteasomal Protein and Inhibit Proteasomal Function

2003 • 407 citations

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.

1986 • 404 citations

Increased Caspase 3 and Bax Immunoreactivity Accompany Nuclear GAPDH Translocation and Neuronal Apoptosis in Parkinson's Disease

2000 • 402 citations

Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity

2003 • 385 citations

α‐Synuclein Up‐Regulation in Substantia Nigra Dopaminergic Neurons Following Administration of the Parkinsonian Toxin MPTP

2000 • 379 citations

Synucleins Are a Novel Class of Substrates for G Protein-coupled Receptor Kinases

2000 • 378 citations

Dopamine transporters and neuronal injury

1999 • 376 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

2001 • 360 citations

α-Synuclein Binds to Tau and Stimulates the Protein Kinase A-catalyzed Tau Phosphorylation of Serine Residues 262 and 356

1999 • 356 citations

Energy Thresholds in Brain Mitochondria

1998 • 354 citations

Pesticides directly accelerate the rate of α‐synuclein fibril formation: a possible factor in Parkinson's disease

2001 • 348 citations

alpha-synuclein gene haplotypes are associated with Parkinson's disease

2001 • 347 citations

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

1986 • 347 citations

Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation.

2001 • 345 citations

Complex I and Parkinson's Disease

2001 • 334 citations

PHASE AND ELECTRON MICROSCOPIC OBSERVATIONS OF LEWY BODIES AND MELANIN GRANULES IN THE SUBSTANTIA NIGRA AND LOCUS CAERULEUS IN PARKINSONʼS DISEASE

1965 • 330 citations

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

2003 • 323 citations

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

1990 • 323 citations

Accumulation of biological amines into chromaffin granules: a model for hormone and neurotransmitter transport

1988 • 323 citations

Chemical Neurotoxins as Denervation Tools in Neurobiology

1980 • 318 citations

Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled

2002 • 316 citations

Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson’s disease?

2000 • 313 citations

DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxα to the Receptor

2001 • 312 citations

Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease

2001 • 310 citations

Protein Misfolding, Amyloid Formation, and Neurodegeneration

2002 • 306 citations

Formation and Removal of α-Synuclein Aggregates in Cells Exposed to Mitochondrial Inhibitors

2002 • 292 citations

Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP ⁺ Binds to Neuromelanin

1986 • 289 citations

The association of incident dementia with mortality in PD

2002 • 287 citations

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

2001 • 286 citations

The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease.

2003 • 286 citations

Lack of Nigral Pathology in Transgenic Mice Expressing Human α-Synuclein Driven by the Tyrosine Hydroxylase Promoter

2001 • 279 citations

6-Hydroxydopamine Lesion of the Rat Substantia Nigra: Time Course and Morphology of Cell Death

1995 • 268 citations

Caspase-8 Is an Effector in Apoptotic Death of Dopaminergic Neurons in Parkinson's Disease, But Pathway Inhibition Results in Neuronal Necrosis

2001 • 265 citations

CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.

1999 • 264 citations

Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat

2001 • 258 citations

Residual Structure and Dynamics in Parkinson's Disease-associated Mutants of α-Synuclein

2001 • 255 citations

IV. MPTP, MPP+ and mitochondrial function

1987 • 249 citations

Carrier-mediated processes in blood–brain barrier penetration and neural uptake of paraquat

2001 • 247 citations

The 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Mouse Model

2003 • 245 citations

Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial Parkinsonism associated with mutations in the Parkin gene

2001 • 244 citations

Rapid ATP Loss Caused by 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine in Mouse Brain

1991 • 242 citations

Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity

1998 • 230 citations

Role of Cytochrome c as a Stimulator of α-Synuclein Aggregation in Lewy Body Disease

1999 • 229 citations

Isoquinoline neurotoxins in the brain and Parkinson's disease

1997 • 227 citations

MPTP Activates c‐Jun NH₂‐Terminal Kinase (JNK) and Its Upstream Regulatory Kinase MKK4 in Nigrostriatal Neurons In Vivo

2000 • 227 citations

Absence of MPTP-Induced Neuronal Death in Mice Lacking the Dopamine Transporter

1999 • 226 citations

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

2001 • 223 citations

Oxy-radical toxicity in catecholamine neurons.

1984 • 221 citations

Parkinson's disease

1985 • 214 citations

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson’s disease

1999 • 214 citations

Similarities and differences between MPTP-induced parkinsonsim and Parkinson's disease. Neuropathologic considerations.

1993 • 209 citations

Protection by Synergistic Effects of Adenovirus-Mediated X-Chromosome-Linked Inhibitor of Apoptosis and Glial Cell Line-Derived Neurotrophic Factor Gene Transfer in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease

2000 • 205 citations

Threshold Effects and Control of Oxidative Phosphorylation in Nonsynaptic Rat Brain Mitochondria

1996 • 204 citations

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

2002 • 202 citations

A mechanism of paraquat toxicity involving nitric oxide synthase

1999 • 200 citations

Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra

1997 • 200 citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride Neurotoxicity Is Attenuated in Mice Overexpressing Bcl-2

1998 • 199 citations

Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.

2001 • 196 citations

Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: Comparison with the mRNA for the D₂ receptor, tyrosine hydroxylase and calbindin immunoreactivity

1995 • 195 citations

Association of Single-Nucleotide Polymorphisms of the Tau Gene With Late-Onset Parkinson Disease

2001 • 195 citations

Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse

1984 • 194 citations

Oxidative post‐translational modifications of α‐synuclein in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model of Parkinson's disease

2001 • 190 citations

Selective retention of MPP+ within the monoaminergic systems of the primate brain following MPTP administration: An in vivo autoradiographic study

1991 • 171 citations

Programmed cell death and the control of cell survival

1994 • 169 citations

Effects of Pharmacological Agents upon a Transgenic Model of Parkinson's Disease in Drosophila melanogaster

2002 • 159 citations

Evaluation of 50 probands with early-onset Parkinson’s disease for Parkin mutations

2002 • 156 citations

Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons

1994 • 155 citations

Selective lesion of central dopamine or noradrenaline neuron systems in the neonatal rat: motor behavior and monoamine alterations at adult stage

1989 • 153 citations

Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1992 • 153 citations

Dose-dependent destruction of the coeruleus-cortical and nigral-striatal projections by MPTP

1990 • 153 citations

Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?

2001 • 149 citations

In Vivo Labeling of Mitochondrial Complex I (NADH:UbiquinoneOxidoreductase) in Rat Brain Using [³H]Dihydrorotenone

2000 • 142 citations

Role of α-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

2003 • 142 citations

Differences in Nigral Neuron Number and Sensitivity to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 Mice

1994 • 140 citations

Neuromelanin and Parkinson's disease.

1983 • 139 citations

Developmental cell death in dopaminergic neurons of the substantia nigra of mice

2000 • 138 citations

Prevention of the Nigrostriatal Toxicity of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine by Inhibitors of 3,4‐Dihydroxyphenylethylamine Transport

1986 • 135 citations

Dopamine Neurons from Transgenic Mice with a Knockout of the p53 Gene Resist MPTP Neurotoxicity

1996 • 135 citations

Microtubule-associated Protein 1B Is a Component of Cortical Lewy Bodies and Binds α-Synuclein Filaments

2000 • 134 citations

Parkinson Disease Survival

2000 • 130 citations

Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration.

1994 • 130 citations

Neurochemistry of Parkinson's disease: relation between striatal and limbic dopamine.

1978 • 130 citations

Apoptosis in substantia nigra following developmental striatal excitotoxic injury.

1994 • 129 citations

α-Synuclein Interacts with Phospholipase D Isozymes and Inhibits Pervanadate-induced Phospholipase D Activation in Human Embryonic Kidney-293 Cells

2002 • 125 citations

Increased susceptibility to MPTP toxicity in middle-aged rhesus monkeys

1995 • 124 citations

Specificity of dopaminergic neuronal degeneration induced by intracerebral injection of 6-hydroxydopamine in the nigrostriatal dopamine system

1976 • 122 citations

Gene transfer of a reserpine-sensitive mechanism of resistance to N-methyl-4-phenylpyridinium.

1992 • 121 citations

Epidemiology of Parkinson’s Disease

1992 • 118 citations

Parkin and Parkinsonʼs disease

2001 • 117 citations

Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in parkinson's disease

1994 • 116 citations

Catecholamine release and uptake in the mouse prefrontal cortex

2001 • 115 citations

Oxidative Stress, Mitochondrial Respiration, and Parkinson's Disease

2000 • 115 citations

Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice.

1991 • 115 citations

Does neuromelanin contribute to the vulnerability of catecholaminergic neurons in monkeys intoxicated with MPTP?

1993 • 106 citations

Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells.

1987 • 101 citations

Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats

1993 • 97 citations

Failure to find the a‐synuclein gene missense mutation (G ²⁰⁹ A) in 100 patients with younger onset Parkinson's disease

1998 • 95 citations

Rat α‐Synuclein Interacts with Tat Binding Protein 1, a Component of the 26S Proteasomal Complex

2000 • 94 citations

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

2001 • 89 citations

Structure/function of α-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

2002 • 87 citations

Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis

1997 • 84 citations

DNA damage in brain mitochondria caused by aging and MPTP treatment

2000 • 78 citations

Cell Death and Diseases of the Nervous System

1999 • 74 citations

Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons

2002 • 74 citations

Effect of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) on monoamine neurotransmitters in mouse brain & heart

1984 • 72 citations

Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the α-synuclein gene in early onset patients

1997 • 69 citations

Free Radicals in Brain Pathophysiology

2000 • 68 citations

Age at onset of Parkinson disease and apolipoprotein E genotypes

2001 • 65 citations

Redox cycling of MPP+: Evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase

1993 • 65 citations

Age-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets

1993 • 61 citations

Apoptosis Versus Necrosis

1999 • 60 citations

The neurotoxin 1-methyl-4-phenylpyridinium is sequestered within neurons that contain the vesicular monoamine transporter

1998 • 58 citations

Lewy bodies of Parkinson's disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments.

1986 • 52 citations

Influence of age on the passage of paraquat through the blood-brain barrier in rats: A distribution and pathological examination

1996 • 50 citations

No changes in behaviour, nigro-striatal system neurochemistry or neuronal cell death following toxic multiple oral paraquat administration to rats

1996 • 49 citations

Effect of MPTP on Brain Mitochondrial H2O2 and ATP Production and on Dopamine and DOPAC in the Striatum

1999 • 48 citations

Interaction of the c-Jun/JNK Pathway and Cyclin-dependent Kinases in Death of Embryonic Cortical Neurons Evoked by DNA Damage

2002 • 47 citations

Increased Expression and Redistribution of the Antiapoptotic Molecule Bcl-xL in Parkinson's Disease

2002 • 45 citations

No genetic association of the Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease

2001 • 44 citations

A Dual Effect of 1-Methyl-4-phenylpyridinium (MPP+)-Analogs on the Respiratory Chain of Bovine Heart Mitochondria

1997 • 42 citations

The Sydney Multicentre Study of Parkinson's disease: a report on the first 3 years.

1989 • 41 citations

CYP2D6 allelic frequencies in young-onset Parkinson's disease

1996 • 41 citations

Free radical and nitric oxide toxicity in Parkinson's disease.

2003 • 35 citations

MPTP and aging. Studies in the C57BL/6 mouse.

1993 • 33 citations

Cellular localization of tyrosine hydroxylase mRNA and cholecystokinin mRNA-containing cells in the ventral mesencephalon of the common marmoset: effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1992 • 25 citations

Parkin-proven disease

2003 • 21 citations

Neurochemistry of Parkinson's disease

2007 • 11 citations