Parkin and Parkinsonʼs disease

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

Association between Early-Onset Parkinson's Disease and Mutations in theParkinGene

2000 • 1,398 citations

RING Finger Proteins

2000 • 1,216 citations

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

2000 • 975 citations

Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity

2000 • 757 citations

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

2000 • 634 citations

The ubiquitin system

2000 • 627 citations

Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease

2000 • 405 citations

The septin CDCrel-1 binds syntaxin and inhibits exocytosis

1999 • 371 citations

The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

2000 • 336 citations

The Inhibitor of Apoptosis, cIAP2, Functions as a Ubiquitin-Protein Ligase and Promotes in VitroMonoubiquitination of Caspases 3 and 7

2000 • 294 citations

Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in the Parkin gene in affected individuals

1998 • 293 citations

Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients

1999 • 274 citations

Paralysis agitans of early onset with marked diurnal fluctuation of symptoms

1973 • 227 citations

Parkin deletions in a family with adult-onset, tremor-dominant parkinsonism: Expanding the phenotype

2000 • 224 citations

An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in theparkin gene

2000 • 209 citations

Expression of ?-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's disease

2000 • 195 citations

Levodopa-responsive dystonia

2000 • 188 citations

The Ligation Systems for Ubiquitin and Ubiquitin-like Proteins

1998 • 97 citations

Parkin expression in the adult mouse brain

2000 • 92 citations

Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism

2000 • 89 citations

Polymorphism in theparkin gene in sporadic Parkinson's disease

1999 • 88 citations

The genetics of Parkinson's disease

2000 • 88 citations

Parkin is associated with actin filaments in neuronal and nonneural cells

2000 • 79 citations

Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene

2000 • 66 citations

Parkin is metabolized by the ubiquitin/proteosome system

2000 • 56 citations

[ ¹⁸ F]-dopa PET study in patients with juvenile-onset PD and parkin gene mutations

2000 • 51 citations

Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies

2001 • 46 citations

Cloning of Rat Parkin cDNA and Distribution of Parkin in Rat Brain

2000 • 45 citations

Progress in the clinical and molecular genetics of familial parkinsonism

2000 • 42 citations

Cloning and distribution of the rat parkin mRNA

2000 • 39 citations

Polymorphisms of the Parkin Gene in Sporadic Parkinson’s Disease among Chinese in Taiwan

2000 • 36 citations

Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?

2000 • 34 citations

Regional and cellular expression of the parkin gene in the rat cerebral cortex

2000 • 31 citations

A new mutation in the parkin gene in a patient with atypical autosomal recessive juvenile parkinsonism

2000 • 29 citations

Exonic deletion mutations of the Parkin gene among sporadic patients with Parkinson's disease

2000 • 20 citations

Spatial distribution, cellular integration and stage development of Parkin protein in Xenopus brain

2001 • 20 citations