Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease?

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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

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1993 • 930 citations

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1988 • 909 citations

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1988 • 738 citations

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1987 • 720 citations

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

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1995 • 687 citations

Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

1997 • 676 citations

Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III

1997 • 650 citations

Dopamine Oxidation Alters Mitochondrial Respiration and Induces Permeability Transition in Brain Mitochondria

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1999 • 594 citations

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

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A cytoplasmic chaperonin that catalyzes β-actin folding

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1992 • 414 citations

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1996 • 383 citations

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Toxicity of 6‐hydroxydopamine and dopamine for dopaminergic neurons in culture

1990 • 334 citations

Dopamine Induces Apoptosis through an Oxidation-involved SAPK/JNK Activation Pathway

1998 • 310 citations

Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis

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Intense oxidative DNA damage promoted by <scp>l</scp>‐DOPA and its metabolites implications for neurodegenerative disease

1994 • 294 citations

Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration

1995 • 288 citations

Iron‐Melanin Interaction and Lipid Peroxidation: Implications for Parkinson's Disease

1991 • 285 citations

Parkinson disease: A new link between monoamine oxidase and mitochondrial electron flow

1997 • 278 citations

Prevention of Dopamine-Induced Cell Death by Thiol Antioxidants: Possible Implications for Treatment of Parkinson's Disease

1996 • 248 citations

Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease.

1995 • 241 citations

Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity

1998 • 230 citations

Studies on Parkinson's Disease Including X-Ray Fluorescent Spectroscopy of Formalin Fixed Brain Tissue

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A family of molecules related to collapsin in the embryonic chick nervous system

1995 • 225 citations

Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons — A possible novel pathogenetic mechanism in Parkinson's disease

1994 • 222 citations

Is the Vulnerability of Neurons in the Substantia Nigra of Patients with Parkinson's Disease Related to Their Neuromelanin Content?

1992 • 221 citations

The induction of multiple cell cycle events precedes target-related neuronal death

1995 • 214 citations

A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution

1996 • 211 citations

Possible role of neuromelanin in the pathogenesis of Parkinson's disease

1983 • 210 citations

Pre- and Postsynaptic Neurotoxic Effects of Dopamine Demonstrated by Intrastriatal Injection

1993 • 204 citations

Secreted Chick Semaphorins Bind Recombinant Neuropilin with Similar Affinities but Bind Different Subsets of Neurons In Situ

1997 • 191 citations

A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis

1996 • 189 citations

Quantitation of Fluorescence of Biogenic Monoamines

1971 • 187 citations

Protective Effects of the Antiparkinsonian Drugs Talipexole and Pramipexole against 1-Methyl-4-phenylpyridinium-Induced Apoptotic Death in Human Neuroblastoma SH-SY5Y Cells

1998 • 183 citations

Full length article

1997 • 173 citations

Toxicity of Dopamine to Striatal Neurons In Vitro and Potentiation of Cell Death by a Mitochondrial Inhibitor

1998 • 173 citations

Collapsin Response Mediator Protein-2 Is Associated with Neurofibrillary Tangles in Alzheimer's Disease

1998 • 172 citations

Nature of Inhibition of Mitochondrial Respiratory Complex I by 6‐Hydroxydopamine

1996 • 171 citations

Neurofibrillary Tangle-Associated Collapsin Response Mediator Protein-2 (CRMP-2) Is Highly Phosphorylated on Thr-509, Ser-518, and Ser-522

2000 • 168 citations

Evidence That Collapsin Response Mediator Protein-2 Is Involved in the Dynamics of Microtubules

2000 • 167 citations

Differential neurotoxicity induced by l-DOPA and dopamine in cultured striatal neurons

1996 • 166 citations

Mitochondrial dysfunction in parkinson's disease

1998 • 161 citations

Dopamine‐Induced Apoptosis Is Mediated by Oxidative Stress and Is Enhanced by Cyanide in Differentiated PC12 Cells

2000 • 154 citations

The Sensory Innervation of the Mouse Spinal Cord May Be Patterned by Differential Expression of and Differential Responsiveness to Semaphorins

1996 • 153 citations

Semaphorins as Mediators of Neuronal Apoptosis

1999 • 152 citations

Melanin, tyrosine hydroxylase, calbindin and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuronal susceptibility in Parkinson's disease

1992 • 152 citations

Peroxynitrite‐ and Nitrite‐Induced Oxidation of Dopamine : Implications for Nitric Oxide in Dopaminergic Cell Loss

1999 • 150 citations

A 70 Amino Acid Region within the Semaphorin Domain Activates Specific Cellular Response of Semaphorin Family Members

1997 • 145 citations

Enhanced Oxidative Stress and Altered Antioxidants in Brains of Bcl‐2‐Deficient Mice

1998 • 138 citations

Mitochondrial toxins in models of neurodegenerative diseases. I: in vivo brain hydroxyl radical production during sytemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions

1997 • 130 citations

Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer’s disease brain is downregulated at the mRNA and dysregulated at the protein level

1999 • 129 citations

DOPAMINE-INDUCED APOPTOSIS IN HUMAN NEURONAL CELLS: INHIBITION BY NUCLEIC ACIDS ANTISENSE TO THE DOPAMINE TRANSPORTER

1996 • 125 citations

Intrastriatal Dopamine Injection Induces Apoptosis Through Oxidation-Involved Activation of Transcription Factors AP-1 and NF-κB in Rats

1999 • 123 citations

Glutaredoxin Protects Cerebellar Granule Neurons from Dopamine-induced Apoptosis by Activating NF-κB via Ref-1

2001 • 120 citations

Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1

1993 • 117 citations

Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1989 • 117 citations

Mechanisms of Dopamine-Induced Cell Death in Cultured Rat Forebrain Neurons: Interactions with and Differences from Glutamate-Induced Cell Death

1997 • 114 citations

SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: Identification of common effectors with p53 and p21 ^Waf1

1999 • 114 citations

Irreversible Inhibition of Mitochondrial Complex I by 7‐(2‐Aminoethyl)‐3,4‐Dihydro‐5‐Hydroxy‐2H‐1,4‐Benzothiazine‐3‐Carboxylic Acid (DHBT‐1): A Putative Nigral Endotoxin of Relevance to Parkinson's Disease

1997 • 111 citations

The likeness of being: Phylogenetically conserved molecular mechanisms of growth cone guidance

1994 • 109 citations

Iron- and Manganese-Catalyzed Autoxidation of Dopamine in the Presence of <scp>l</scp>-Cysteine: Possible Insights into Iron- and Manganese-Mediated Dopaminergic Neurotoxicity

1998 • 106 citations

Methamphetamine‐Induced Dopamine Overflow and Injury to Striatal Dopamine Terminals: Attenuation by Dopamine D₁ or D₂ Antagonists

1993 • 104 citations

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells

1997 • 103 citations

Dopamine induces apoptotic cell death of a catecholaminergic cell line derived from the central nervous system.

1996 • 101 citations

Enhancing Effect of Manganese on L‐DOPA‐Induced Apoptosis in PC12 Cells

1999 • 95 citations

Dopamine–melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease

1997 • 91 citations

Levodopa induces apoptosis in cultured neuronal cells—A possible accelerator of nigrostriatal degeneration in Parkinson's disease?

1997 • 89 citations

Growth cones and the cues that repel them

1996 • 87 citations

Expression of c‐fos, c‐jun, and N‐terminal kinase (JNK) in a Development Model of Induced Apoptotic Death in Neurons of the Substantia Nigra

1999 • 86 citations

Semaphorin III Can Induce Death in Sensory Neurons

1999 • 86 citations

Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by l-BSO and apoptosis

2000 • 85 citations

Activation of nuclear transcription factor kappa B (NF‐κB) is essential for dopamine‐induced apoptosis in PC12 cells

2001 • 84 citations

Dopamine and Iron Induce Apoptosis in PC12 Cells

1997 • 79 citations

NEURONAL PIGMENTS: SPECTROSCOPIC CHARACTERIZATION OF HUMAN BRAIN MELANIN

1978 • 75 citations

Glutaredoxin Protects Cerebellar Granule Neurons from Dopamine-induced Apoptosis by Dual Activation of the Ras-Phosphoinositide 3-Kinase and Jun N-terminal Kinase Pathways

2001 • 75 citations

Levodopa neurotoxicity

1998 • 74 citations

Dopamine-induced apoptosis is inhibited in PC12 cells expressing Bcl-2.

1997 • 72 citations

Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine

1998 • 70 citations

Studies on the toxicity of 1-methyl-4-phenylpyridinium ion (MPP+) against mitochondria of mouse brain

1988 • 68 citations

Monoamine-induced apoptotic neuronal cell death.

1997 • 66 citations

In Vitro Induction of Apoptosis or Differentiation by Dopamine in an Immortalized Olfactory Neuronal Cell Line

1997 • 64 citations

Iron as catalyst for oxidative stress in the pathogenesis of Parkinson's disease?

1999 • 63 citations

Dopamine induces apoptosis in cultured rat striatal neurons; possible mechanism of D2-dopamine receptor neuron loss during aging

1997 • 63 citations

Selective protection by hsp 70 against cytotoxic drug‐, but not Fas‐induced T‐cell apoptosis

1999 • 54 citations

Intrastriatal injection of dopamine results in DNA damage and apoptosis in rats

1998 • 52 citations

Brain Mitochondria Catalyze the Oxidation of 7‐(2‐Aminoethyl)‐3,4‐Dihydro‐5‐Hydroxy‐2H‐1,4‐Benzothiazine‐3‐Carboxylic Acid (DHBT‐1) to Intermediates that Irreversibly Inhibit Complex I and Scavenge Glutathione: Potential Relevance to the Pathogenesis of Parkinson's Disease

1998 • 50 citations

Dopamine induces neutrophil apoptosis through a dopamine D-1 receptor–independent mechanism

1999 • 50 citations

The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.

1999 • 47 citations

Neurotransmitters, KCl and antioxidants rescue striatal neurons from apoptotic cell death in culture

1999 • 44 citations

Formation of DNA Adducts and Oxidative Base Damage by Copper Mediated Oxidation of Dopamine and 6-Hydroxydopamine

1997 • 44 citations

Two Waves of Cyclin B and Proliferating Cell Nuclear Antigen Expression During Dopamine‐Triggered Neuronal Apoptosis

1997 • 44 citations

Distribution of semaphorin IV in adult human brain

1999 • 41 citations

Expression of cell cycle-related genes during neuronal apoptosis: is there a distinct pattern?

1998 • 40 citations

DNA damage induced by catechol derivatives

2000 • 39 citations

MPP+-Induced Mitochondrial Dysfunction Is Potentiated by Dopamine

2000 • 39 citations

Glutathione protects PC12 cells from ascorbate- and dopamine-induced apoptosis

1998 • 38 citations

Deficiencies of NADH and succinate dehydrogenases in degenerative diseases and myopathies

1995 • 37 citations

Dopamine-releasing action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) in the neostriatum of the rat as demonstrated in vivo by the push-pull perfusion technique: dependence on sodium but not calcium ions

1988 • 32 citations

Tyrosinase enhances the covalent modification of DNA by dopamine

1996 • 32 citations

Bcl‐2 and p53: Role in Dopamine‐Induced Apoptosis and Differentiation

1999 • 31 citations

1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats

1998 • 30 citations

Bcl-2 overexpression attenuates dopamine-induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen species

2000 • 29 citations

Bcl‐2 overexpression attenuates dopamine‐induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen species

2000 • 28 citations

The proto-oncogene Bcl-2 inhibits cellular toxicity of dopamine: possible implications for Parkinson‘s Disease

1997 • 20 citations

Heat shock proteins protect cultured fibroblasts from the cytotoxic effects of MPP+

1996 • 17 citations

Induction of apoptosis by dopamine in human oral tumor cell lines.

2000 • 17 citations

Relationship between radical intensity and cytotoxic activity of dopamine-related compounds.

1998 • 15 citations

Involvement of T-complex Protein-1δ in Dopamine Triggered Apoptosis in Chick Embryo Sympathetic Neurons

2000 • 7 citations

Brain Iron and other Trace Metals in Neurodegenerative Diseases

2000 • 4 citations