Prospects for new restorative and neuroprotective treatments in Parkinson's disease

Mitochondria and Apoptosis

1998 • 8,909 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Primate models of movement disorders of basal ganglia origin

1990 • 3,722 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE

1999 • 1,387 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

Parkinson Disease in Twins<SUBTITLE>An Etiologic Study</SUBTITLE>

1999 • 861 citations

Understanding cell death in parkinson's disease

1998 • 678 citations

Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy

1997 • 637 citations

SUCCESS AND PROBLEMS OF LONG-TERM LEVODOPA THERAPY IN PARKINSON'S DISEASE

1977 • 585 citations

Rate of cell death in parkinsonism indicates active neuropathological process

1988 • 545 citations

Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats

1998 • 539 citations

Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease

1997 • 469 citations

AETIOLOGY OF PARKINSON'S DISEASE

1983 • 463 citations

A susceptibility locus for Parkinson's disease maps to chromosome 2p13

1998 • 461 citations

Subthalamic nucleus‐mediated excitotoxicity in parkinson's disease: A target for neuroprotection

1998 • 395 citations

An [¹⁸F]dopa–PET and clinical study of the rate of progression in Parkinson’s disease

1996 • 359 citations

Short‐ and long‐term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease

1997 • 358 citations

Oxidative stress and antioxidant therapy in Parkinson's disease

1996 • 342 citations

Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson’s disease in rats

1997 • 341 citations

Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

1997 • 326 citations

Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease

1997 • 301 citations

Differentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines

1998 • 298 citations

Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease

1998 • 295 citations

Caspase inhibition reduces apoptosis and increases survival of nigral transplants

1999 • 283 citations

Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.

1994 • 270 citations

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease

1995 • 269 citations

Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopa

1991 • 261 citations

Studies on Neuroprotective and Regenerative Effects of GDNF in a Partial Lesion Model of Parkinson's Disease

1997 • 243 citations

Functional neural transplantation

1994 • 242 citations

Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats

1998 • 219 citations

Correspondence

1996 • 215 citations

Neural actions of immunophilin ligands

1998 • 202 citations

A fluorescent double‐labeling method to detect and confirm apoptotic nuclei in parkinson's disease

1998 • 198 citations

Metals and free radicals in neurodegeneration

1994 • 197 citations

Behavioral and Cellular Protection of Rat Dopaminergic Neurons by an Adenoviral Vector Encoding Glial Cell Line-Derived Neurotrophic Factor

1998 • 195 citations

Alpha synuclein in neurodegenerative disorders: Murderer or accomplice?

1998 • 190 citations

United Parkinson Foundation Neurotransplantation Registry on adrenal medullary transplants

1991 • 177 citations

Epidemiology versus genetics in parkinson's disease: Progress in resolving an age‐old debate

1998 • 169 citations

Mortality in DATATOP: A Multicenter trial in early Parkinson's disease

1998 • 166 citations

GDNF Reduces Drug-Induced Rotational Behavior after Medial Forebrain Bundle Transection by a Mechanism Not Involving Striatal Dopamine

1997 • 158 citations

Neuroprotective and neurorestorative properties of GDNF

1998 • 157 citations

Functional Recovery in Hemiparkinsonian Primates Transplanted with Polymer-Encapsulated PC12 Cells

1994 • 155 citations

Alzheimer's disease and parkinson's disease: Distinct entities or extremes of a spectrum of neurodegeneration?

1998 • 151 citations

The early diagnosis of parkinson's disease

1998 • 150 citations

Rationale for continuous dopaminomimetic therapy of Parkinson's disease.

1989 • 147 citations

Generation of DOPA-Producing Astrocytes by Retroviral Transduction of the Human Tyrosine Hydroxylase Gene:In VitroCharacterization andin VivoEffects in the Rat Parkinson Model

1996 • 140 citations

Neural-Targeted Gene Therapy for Rodent and Primate Hemiparkinsonism

1994 • 139 citations

Low frequency of α‐synuclein mutations in familial Parkinson's disease

1998 • 137 citations

GDNF enhances dopaminergic cell survival and fibre outgrowth in embryonic nigral grafts

1996 • 135 citations

Cellular and Functional Recovery of Parkinsonian Rats after Intrastriatal Transplantation of Carotid Body Cell Aggregates

1998 • 135 citations

Dopamine agonists and neuroprotection in parkinson's disease

1998 • 130 citations

Last chance to stop and think on risks of xenotransplants

1998 • 127 citations

Ethical guidelines for the use of human embryonic or fetal tissue for experimental and clinical neurotransplantation and research

1994 • 125 citations

Neural transplantation

1997 • 119 citations

The natural history of parkinson's disease

1998 • 117 citations

An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats

1989 • 117 citations

Fetal grafting for Parkinson's disease: Expression of immune markers in two patients with functional fetal nigral implants

1997 • 117 citations

Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts.

1996 • 109 citations

Dopaminergic Transplants in Patients with Parkinson's Disease: Neuroanatomical Correlates of Clinical Recovery

1997 • 108 citations

Neural xenotransplantation: Reconstruction of neuronal circuitry across species barriers

1994 • 105 citations

A Novel Immunophilin Ligand: Distinct Branching Effects on Dopaminergic Neurons in Culture and Neurotrophic Actions after Oral Administration in an Animal Model of Parkinson's Disease

1998 • 105 citations

Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro

1995 • 104 citations

Programmed cell death: Does it play a role in parkinson's disease?

1998 • 103 citations

Neurotrophins Prevent Death and Differentially Affect Tyrosine Hydroxylase of Adult Rat Nigrostriatal Neuronsin Vivo

1998 • 98 citations

Double Transduction with GTP Cyclohydrolase I and Tyrosine Hydroxylase Is Necessary for Spontaneous Synthesis ofl-DOPA by Primary Fibroblasts

1996 • 94 citations

Bcl-xL protects adult septal cholinergic neurons from axotomized cell death

1998 • 91 citations

Glial Cell Line-Derived Neurotrophic Factor Improves Survival of Dopaminergic Neurons in Transplants of Fetal Ventral Mesencephalic Tissue

1998 • 89 citations

The causes of parkinson's disease are being unraveled and rational neuroprotective therapy is close to reality

1998 • 79 citations

Fetal Grafting for Parkinson's Disease: Expression of Immune Markers in Two Patients with Functional Fetal Nigral Implants

1997 • 70 citations

Chronic intracerebral stimulation in Parkinson's disease.

1997 • 65 citations

Benefits and risks of hosting animal cells in the human brain

1997 • 64 citations

In VivoL-DOPA Production by Genetically Modified Primary Rat Fibroblast or 9L Gliosarcoma Cell Grafts via Coexpression of GTPcyclohydrolase I with Tyrosine Hydroxylase

1998 • 62 citations

Genetics of parkinson's disease

1998 • 61 citations

Mitogenic effect of basic fibroblast growth factor on embryonic ventral mesencephalic dopaminergic neurone precursors

1993 • 61 citations

Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor.

1995 • 58 citations

Sustained behavioral recovery from unilateral nigrostriatal damage produced by the controlled release of dopamine from a silicone polymer pellet placed into the denervated striatum

1990 • 56 citations

Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease

1997 • 49 citations

Polymer-Encapsulated PC12 Cells Promote Recovery of Motor Function in Aged Rats

1993 • 48 citations

Memory in Neurodegenerative Disease

1998 • 46 citations

Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat

1994 • 45 citations

Neural transplantation as a therapy for Parkinson's disease.

1997 • 43 citations

Functional Neural Transplantation

1995 • 42 citations

Neuropathology of fetal nigral grafts in patients with Parkinson's disease.

1998 • 33 citations

Neuroprotection for parkinson's disease

1998 • 28 citations

Growth Factor Function in the Development and Maintenance of Midbrain Dopaminergic Neurons: Concepts, Facts and Prospects for TGF‐β

2007 • 25 citations

Potential of gene therapy for Parkinson's disease: neurobiologic issues and new developments in gene transfer methodologies.

1998 • 20 citations

The role of executive deficits in memory disorders in neurodegenerative disease

1998 • 14 citations

An introduction to the new surgery for Parkinson's disease. Past and present problems.

1997 • 10 citations

Cell death and neuroprotection in Parkinson's disease

2000 • 7 citations

Deleted Work

1955 • 0 citations