Toxicity of 6‐hydroxydopamine and dopamine for dopaminergic neurons in culture

Chemical Neuroanatomy

1984 • 1,646 citations

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1988 • 1,235 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones.

1978 • 1,073 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Pharmacological actions of 6-hydroxydopamine.

1974 • 792 citations

Catecholamines: Basic and Clinical Frontiers

1979 • 730 citations

EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN

1970 • 653 citations

6-Hydroxydopamine and catecholamine neurons

1971 • 637 citations

Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine

1971 • 535 citations

Light‐microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. II. Late ontogeny

1981 • 497 citations

Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.

1970 • 486 citations

A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra

1989 • 445 citations

Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas.

1969 • 445 citations

An electron microscopic study of selective, acute degeneration of sympathetic nerve terminals after administration of 6-hydroxydopamine

1968 • 442 citations

Light‐microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. I. Early ontogeny

1981 • 349 citations

Monoamine Innervation of the Cerebral Cortex

1985 • 308 citations

The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence.

1983 • 224 citations

Possible role of neuromelanin in the pathogenesis of Parkinson's disease

1983 • 210 citations

Catecholamine toxicity in cerebral cortex in dissociated cell culture

1988 • 207 citations

Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine

1972 • 204 citations

Quantitation of Fluorescence of Biogenic Monoamines

1971 • 187 citations

Model experiments on the molecular mechanism of action of 6-hydroxydopamine.

1971 • 170 citations

Specific stimulation of in vitro maturation of mesencephalic dopaminergic neurones by striatal membranes

1981 • 151 citations

Semiquinone anion radicals from addition of amino acids, peptides, and proteins to quinones derived from oxidation of catechols and catecholamines. An ESR spin stabilization study.

1987 • 151 citations

Non-specific histopathological changes induced by the intracerebral injection of 6-hydroxy-dopamine (6-OH-DA)

1972 • 149 citations

Serum Factor Supporting Long-Rerm Survival of Rat Central Neurons in Culture

1983 • 113 citations

Selective Destruction of Cultured Dopaminergic Neurons from Fetal Rat Mesencephalon by 1‐Methyl‐4‐Phenylpyridinium: Cytochemical and Morphological Evidence

1988 • 87 citations

Studies on the Oxidation of the Dopaminergic Neurotoxin 1‐Methyl‐4‐Phenyl‐1,2,5,6‐Tetrahydropyridine by Monoamine Oxidase B

1985 • 83 citations

Toxicity of 1‐Methyl‐4‐Phenylpyridinium for Rat Dopaminergic Neurons in Culture: Selectivity and Irreversibility

1990 • 76 citations

1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in cultures of dissociated rat mesencephalic neurons

1986 • 73 citations

Katecholaminhaltige Neurone in der neuroendokrinen Steuerung Prinzip, Anwendung der Mikrofluorimetrie

1970 • 58 citations

Toxic effects of potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium on cultured rat dopaminergic neurons.

1989 • 46 citations

Amine-mediated toxicity

1986 • 40 citations

Inhibition of catecholamine uptake by 6-hydroxydopamine in rat brain

1970 • 39 citations

EVIDENCE FOR DEGENERATION OF SYMPATHETIC NERVE TERMINALS CAUSED BY THE ORTHO‐ AND PARA‐QUINONES OF 6‐HYDROXYDOPAMINE

1973 • 28 citations

Studies on the Formation of 6‐Hydroxydopamine in Mouse Brain After Administration of 2,4,5‐Trihydroxyphenylalanine (6‐HydroxyDOPA)

1989 • 14 citations

Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: Selective toxicity of 1-methyl-4-(4′-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture

1990 • 13 citations

Cross-Linking of Protein Molecules by the Reactive Metabolite of Acetaminophen, N-Acetyl-p-Benzoquinone Imine, and Related Quinoid Compounds

1986 • 8 citations

STUDIES ON THE MODE OF ACTION OF 6-HYDROXYDOPAMINE AND RELATED NEUROTOXINS

1979 • 1 citations