Is the Vulnerability of Neurons in the Substantia Nigra of Patients with Parkinson's Disease Related to Their Neuromelanin Content?

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1988 • 1,235 citations

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones.

1978 • 1,073 citations

Histopathologic Technic and Practical Histochemistry

1966 • 989 citations

Greenfield's neuropathology

1976 • 961 citations

Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.

1991 • 543 citations

Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray Microanalysis

1991 • 518 citations

Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease.

1984 • 291 citations

Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?

1989 • 290 citations

Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP ⁺ Binds to Neuromelanin

1986 • 289 citations

Subdivisions of the dopamine-containing A8-A9-A10 complex identified by their differential mesostriatal innervation of striosomes and extrastriosomal matrix

1987 • 276 citations

Possible role of neuromelanin in the pathogenesis of Parkinson's disease

1983 • 210 citations

LIPOPROTEIN PIGMENTS—THEIR RELATIONSHIP TO AGEING IN THE HUMAN NERVOUS SYSTEM

1974 • 207 citations

A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics.

1983 • 197 citations

Differences in tyrosine hydroxylase-like immunoreactivity characterize the mesostriatal innervation of striosomes and extrastriosomal matrix at maturity.

1987 • 146 citations

Neuromelanin and Parkinson's disease.

1983 • 139 citations

An Antigenic Profile of Lewy Bodies: Immunocytochemical Indication for Protein Phosphorylation and Ubiquitination

1989 • 138 citations

Evidence for neuromelanin involvement in MPTP-induced neurotoxicity

1987 • 120 citations

Advances in Neurology, vol 53, Parkinson's Disease: Anatomy, Pathology, and Therapy

1991 • 98 citations

Topographic immunocytochemical mapping of monoamine oxidase-A, monoamine oxidase-B and tyrosine hydroxylase in human post mortem brain stem

1988 • 96 citations

NEURONAL PIGMENTS: SPECTROSCOPIC CHARACTERIZATION OF HUMAN BRAIN MELANIN

1978 • 75 citations

Quantitative Autoradiography of Tyrosine Hydroxylase Immunoreactivity in the Rat Brain

1991 • 50 citations

Quantitative image analysis with densitometry for immunohistochemistry and autoradiography of receptor binding sites—methodological considerations

1991 • 48 citations

Catecholaminergic systems in the medulla oblongata in parkinsonian syndromes

1990 • 33 citations

Binding of dopaminergic drugs by the neuromelanin of the substantia nigra, synthetic melanins and melanin granules.

1978 • 33 citations

Microtopography of d1 dopaminergic binding sites in the human substantia nigra: An autoradiographic study

1990 • 26 citations

monoclonal antibodies raised against Lewy bodies in brains from subjects with Parkinson's disease

1985 • 15 citations