Hepatocellular Carcinoma

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

2010 • 21,372 citations

Hepatocellular carcinoma

2012 • 3,818 citations

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

2012 • 3,075 citations

Risk of Hepatocellular Carcinoma Across a Biological Gradient of Serum Hepatitis B Virus DNA Level

2006 • 3,012 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity

2012 • 1,763 citations

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

2012 • 1,322 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

2006 • 1,129 citations

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

2009 • 1,075 citations

Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling

2004 • 874 citations

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

2012 • 850 citations

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

2012 • 822 citations

Statements from the Taormina expert meeting on occult hepatitis B virus infection

2008 • 789 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

2013 • 671 citations

Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection

2012 • 660 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

1978 • 657 citations

Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma

1980 • 610 citations

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

2013 • 599 citations

Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score

2011 • 595 citations

Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.

1978 • 588 citations

Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of Hepatocellular Carcinoma

2008 • 567 citations

The Enigmatic X Gene of Hepatitis B Virus

2004 • 486 citations

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

2011 • 407 citations

Mechanisms of HBV-related hepatocarcinogenesis

2010 • 394 citations

Associations Between Hepatitis B Virus Mutations and the Risk of Hepatocellular Carcinoma: A Meta-Analysis

2009 • 372 citations

A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.

1980 • 367 citations

Infectious agents and cancer: criteria for a causal relation

2004 • 329 citations

Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas

2005 • 313 citations

Association of Nucleos(t)ide Analogue Therapy With Reduced Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B—A Nationwide Cohort Study

2014 • 292 citations

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

1997 • 286 citations

Molecular functions and biological roles of hepatitis B virus x protein

2006 • 281 citations

The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients

2012 • 281 citations

Hepatocarcinogenicity of the woodchuck hepatitis virus.

1987 • 273 citations

Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours

1990 • 245 citations

Hepatitis B virus PreS/S gene variants: Pathobiology and clinical implications

2014 • 238 citations

The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.

1987 • 204 citations

Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma

1988 • 192 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis

2009 • 177 citations

Virus associated malignancies: The role of viral hepatitis in hepatocellular carcinoma

2014 • 172 citations

Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat.

1984 • 156 citations

Chapter 4 Hepatitis B Virus X Protein

2009 • 148 citations

Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: Presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections

1989 • 147 citations

Effectiveness of Hepatitis B Treatment in Clinical Practice

2012 • 145 citations

Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues.

1990 • 140 citations

Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection

2004 • 133 citations

HBsAg andHBx knocked into thep21 locus causes hepatocellular carcinoma in mice

2004 • 123 citations

Hepatitis B Virus X and Regulation of Viral Gene Expression

2016 • 120 citations

Mutational landscape of HCC—the end of the beginning

2014 • 109 citations

The function of targeted host genes determines the oncogenicity of HBV integration in hepatocellular carcinoma

2013 • 106 citations

Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients

2000 • 105 citations

Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations

2012 • 103 citations

Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1

2008 • 99 citations

Evidence for long-range oncogene activation by hepadnavirus insertion.

1994 • 99 citations

Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection

2005 • 99 citations

Transcriptomic analysis of the woodchuck model of chronic hepatitis B

2012 • 91 citations

Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors

1992 • 81 citations

Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration

1989 • 80 citations

Alteration of Gene Expression in Human Hepatocellular Carcinoma with Integrated Hepatitis B Virus DNA

2005 • 77 citations

Interaction of Hepatitis B Viral Oncoprotein with Cellular Target HBXIP Dysregulates Centrosome Dynamics and Mitotic Spindle Formation

2007 • 76 citations

Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver

2009 • 71 citations

Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from a chronically infected liver

1984 • 61 citations

Integration of woodchuck hepatitis and N-myc rearrangement determine size and histologic grade of hepatic tumors

2004 • 54 citations

Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion.

1994 • 51 citations

Hepatocellular carcinoma in WHV/N-myc2 transgenic mice: oncogenic mutations of β-catenin and synergistic effect of p53 null alleles

2000 • 48 citations

Polo-like Kinase 1 Activated by the Hepatitis B Virus X Protein Attenuates Both the DNA Damage Checkpoint and DNA Repair Resulting in Partial Polyploidy

2010 • 44 citations

Are novel combination therapies needed for chronic hepatitis B?

2012 • 40 citations

Activation of the N-myc2 Oncogene by Woodchuck Hepatitis Virus Integration in the Linked Downstreamb3nLocus in Woodchuck Hepatocellular Carcinoma

1999 • 29 citations

Animal Models and the Molecular Biology of Hepadnavirus Infection

2015 • 27 citations