Alteration of Gene Expression in Human Hepatocellular Carcinoma with Integrated Hepatitis B Virus DNA

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

An Introduction to Multivariate Statistical Analysis

1986 • 9,529 citations

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation

2002 • 3,503 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Estimates of the worldwide mortality from 25 cancers in 1990

1999 • 1,494 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma

1986 • 399 citations

Cloning and structural analyses of hepatitis B virus DNAs, subtypeadr

1983 • 309 citations

Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours

1990 • 245 citations

Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers

2003 • 229 citations

Design and Testing of β-Actin Primers for RT-PCR that Do Not Co-amplify Processed Pseudogenes

1997 • 182 citations

Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis.

1990 • 162 citations

Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat.

1984 • 156 citations

Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.

1986 • 155 citations

RREB-1, a Novel Zinc Finger Protein, Is Involved in the Differentiation Response to Ras in Human Medullary Thyroid Carcinomas

1996 • 148 citations

Somatic mutation of mitochondrial DNA in cancerous and noncancerous liver tissue in individuals with hepatocellular carcinoma.

2001 • 139 citations

Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer.

1991 • 125 citations

Selective amplification of cDNA sequence from total RNA by cassette-ligation mediated polymerase chain reaction (PCR): Application to sequencing 6·5 kb genome segment of hantavirus strain B-1

1992 • 123 citations

Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line

1985 • 113 citations

MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines

1999 • 107 citations

Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging

2001 • 105 citations

MLL2: A New Mammalian Member of the trx/MLL Family of Genes

1999 • 89 citations

Amplification and sequence analysis of DNA flanking integrated proviruses by a simple two-step polymerase chain reaction method

1993 • 87 citations

p16INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB

2003 • 83 citations

Identification of hepatitis B virus integration in hepatitis C virus-infected hepatocellular carcinoma tissues

1997 • 73 citations

Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma

1991 • 71 citations

A Novel PCR Technique UsingAlu-Specific Primers to Identify Unknown Flanking Sequences from the Human Genome

1995 • 68 citations

Possible contribution to hepatocarcinogenesis of X transcript of hepatitis B virus in japanese patients with hepatitis C virus

1999 • 62 citations

Calmodulin Binds to p21Cip1 and Is Involved in the Regulation of Its Nuclear Localization

1999 • 56 citations

The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.

1997 • 39 citations

Frequent loss of chromosome 8p in hepatitis B virus-positive hepatocellular carcinomas from China.

1996 • 36 citations

Inverse polymerase chain reaction for cloning cellular sequences adjacent to integrated hepatitis B virus DNA in hepatocellular carcinomas

1994 • 31 citations

State of HBV DNA in HBsAg‐negative, anti‐HCV‐positive hepatocellular carcinoma: Existence of HBV DNA possibly as nonintegrated form with analysis by Alu‐HBV DNA PCR and conventional HBV PCR

2001 • 21 citations