Hepatitis B virus PreS/S gene variants: Pathobiology and clinical implications

Van Damme A.

1986 • 3,477 citations

Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease

2004 • 2,260 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Hepatitis B Virus Biology

2000 • 1,426 citations

Vaccine-induced escape mutant of hepatitis B virus

1990 • 1,081 citations

Hepatitis B Virus Infection

2008 • 955 citations

Long-term Therapy With Adefovir Dipivoxil for HBeAg-Negative Chronic Hepatitis B for up to 5 Years

2006 • 890 citations

Large surface proteins of hepatitis B virus containing the pre-s sequence

1984 • 812 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Hepatitis B Virus Resistance to Nucleos(t)ide Analogues

2009 • 666 citations

Occult hepatitis B virus infection

2006 • 541 citations

Control of cccDNA function in hepatitis B virus infection

2009 • 509 citations

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.

1993 • 454 citations

Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review

2010 • 441 citations

The role of envelope proteins in hepatitis B virus assembly.

1991 • 389 citations

Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region

2001 • 388 citations

Associations Between Hepatitis B Virus Mutations and the Risk of Hepatocellular Carcinoma: A Meta-Analysis

2009 • 372 citations

Hepatitis B viruses: Reverse transcription a different way

2008 • 357 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

Clinical relevance of hepatitis B viral mutations

2000 • 348 citations

Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification

1990 • 332 citations

Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis

1998 • 324 citations

Low Resistance to Adefovir Combined With Lamivudine: A 3-Year Study of 145 Lamivudine-Resistant Hepatitis B Patients

2007 • 320 citations

Nucleic Acid Testing to Detect HBV Infection in Blood Donors

2011 • 312 citations

Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation

2007 • 309 citations

Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma.

1994 • 307 citations

Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen

1994 • 304 citations

Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage

2004 • 288 citations

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator

1990 • 284 citations

Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation

1998 • 274 citations

Hepatitis B virus genetic variability and evolution

2007 • 273 citations

High Prevalence and Mapping of Pre-S Deletion in Hepatitis B Virus Carriers With Progressive Liver Diseases

2006 • 270 citations

Hepatitis B virus morphogenesis

2007 • 268 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Hepatitis B virus-induced oncogenesis

2007 • 264 citations

Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine

2004 • 259 citations

Hepatitis B virus pre‐S mutants, endoplasmic reticulum stress and hepatocarcinogenesis

2006 • 258 citations

Endoplasmic Reticulum Stress Stimulates the Expression of Cyclooxygenase-2 through Activation of NF-κB and pp38 Mitogen-activated Protein Kinase

2004 • 243 citations

New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA

2004 • 238 citations

Pre-S Deletion and Complex Mutations of Hepatitis B Virus Related to Advanced Liver Disease in HBeAg-Negative Patients

2007 • 225 citations

Different Types of Ground Glass Hepatocytes in Chronic Hepatitis B Virus Infection Contain Specific Pre-S Mutants that May Induce Endoplasmic Reticulum Stress

2003 • 218 citations

The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound

2008 • 218 citations

In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplified by an intracellular pathway

1990 • 216 citations

Transfusion-transmitted hepatitis B virus infection

2009 • 212 citations

Inhibition of Secretion of Hepatitis B Surface Antigen by a Related Presurface Polypeptide

1986 • 211 citations

Genetic variability of the S gene of hepatitis B virus: clinical and diagnostic impact

2004 • 211 citations

Occult HBV infection

2012 • 204 citations

Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection

2001 • 203 citations

Occult hepatitis B virus infection: a covert operation

2009 • 203 citations

The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma

2005 • 202 citations

Morphogenetic and regulatory effects of mutations in the envelope proteins of an avian hepadnavirus

1991 • 198 citations

Molecular basis of hepatitis B virus serotype variations within the four major subtypes

1992 • 196 citations

Minimization of hepatitis B infection by a 25-year universal vaccination program

2012 • 196 citations

The virological and clinical significance of mutations in the overlapping envelope and polymerase genes of hepatitis B virus

2002 • 196 citations

Hepatitis B virus infection and transfusion medicine: science and the occult

2008 • 193 citations

High-level expression of hepatitis B viral antigens in fibrosing cholestatic hepatitis

1992 • 192 citations

Hepatitis B Virus Envelope Variation After Transplantation With and Without Hepatitis B Immune Globulin Prophylaxis

1996 • 189 citations

Formation of Hepatitis B Virus Covalently Closed Circular DNA: Removal of Genome-Linked Protein

2007 • 188 citations

Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen–negative Chinese carriers

2001 • 185 citations

Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody—treated liver transplant patients

1992 • 183 citations

Virological suppression does not prevent the development of hepatocellular carcinoma in HBeAg-negative chronic hepatitis B patients with cirrhosis receiving oral antiviral(s) starting with lamivudine monotherapy: results of the nationwide HEPNET. Greece cohort study

2011 • 182 citations

Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors

2012 • 174 citations

Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis

1997 • 169 citations

Molecular Genetics of HBV Infection

2010 • 165 citations

The PreS2 activator MHBst of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice

2002 • 162 citations

Cytoplasmic hepatitis B antigen in "ground-glass" hepatocytes of carriers.

1973 • 161 citations

Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic Hepatitis B virus infection

2004 • 161 citations

The Hepatitis B Virus Large Surface Protein (LHBs) Is a Transcriptional Activator

1996 • 147 citations

A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA.

1990 • 145 citations

Infectious Hepatitis B Virus Variant Defective in Pre-S2 Protein Expression in a Chronic Carrier

1993 • 139 citations

Generation of Covalently Closed Circular DNA of Hepatitis B Viruses via Intracellular Recycling Is Regulated in a Virus Specific Manner

2010 • 132 citations

Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver

2003 • 131 citations

Mutant hepatitis B viruses: a matter of academic interest only or a problem with far-reaching implications?

2001 • 131 citations

The Hepatitis B Virus and Common Mutants

2003 • 131 citations

Impact of hepatitis B virus (HBV) preS/S genomic variability on HBV surface antigen and HBV DNA serum levels

2012 • 129 citations

Hepatitis B virus escape mutants induced by antiviral therapy

2008 • 127 citations

Ground glass hepatocytes contain pre‐S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection

2008 • 126 citations

Integrated hepatitis B virus X and 3' truncated preS/S sequences derived from human hepatomas encode functionally active transactivators.

1994 • 119 citations

Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes

2005 • 115 citations

Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice

1995 • 114 citations

HBV Life Cycle: Entry and Morphogenesis

2009 • 111 citations

Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis

2009 • 110 citations

Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease

2003 • 107 citations

Pre-S2 defective hepatitis B virus infection in patients with fulminant hepatitis

1997 • 106 citations

Combined Mutations in Pre‐S/Surface and Core Promoter/Precore Regions of Hepatitis B Virus Increase the Risk of Hepatocellular Carcinoma: A Case-Control Study

2008 • 104 citations

High prevalence of occult hepatitis B virus infection in children born to HBsAg-positive mothers despite prophylaxis with hepatitis B vaccination and HBIG

2012 • 102 citations

A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassembly

1997 • 102 citations

Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy

1992 • 100 citations

A unique insertion in theS gene of surface antigen–negative hepatitis B virus Chinese carriers

1995 • 99 citations

Properties of Hepatitis B Virus Pre-S1 Deletion Mutants

1994 • 97 citations

Hypermodification and Immune Escape of an Internally Deleted Middle-Envelope (M) Protein of Frequent and Predominant Hepatitis B Virus Variants

2002 • 97 citations

Association of Hepatitis B Virus Pre-S Deletions with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B

2011 • 96 citations

Prevalence of naturally occurring surface antigen variants of hepatitis B virus in Korean patients infected chronically

2005 • 96 citations

Altered antigenicity of 'a' determinant variants of hepatitis B virus.

1997 • 94 citations

Hepatitis B virus surface antigen and polymerase gene variants: Potential virological and clinical significance

1998 • 91 citations

A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis

2001 • 87 citations

Hepatocellular carcinoma: the point of view of the hepatitis B virus

2011 • 86 citations

Infectivity and Pathogenicity in Chimpanzees of a Surface Gene Mutant of Hepatitis B Virus that Emerged in a Vaccinated Infant

1997 • 85 citations

The concept of hepatitis B virus mutant escape

2005 • 85 citations

No Increase in Prevalence of Hepatitis B Surface Antigen Mutant in a Population of Children and Adolescents Who Were Fully Covered by Universal Infant Immunization

2010 • 82 citations

Hepatitis B virus mutations in the pre-S genome before and after liver transplantatio

1996 • 82 citations

Nucleotide change of codon 182 in the surface gene of hepatitis B virus genotype C leading to truncated surface protein is associated with progression of liver diseases

2011 • 79 citations

Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes

1994 • 77 citations

Hepatitis B virus surface mutations associated with infection after liver transplantation

1996 • 77 citations

Deficiencies in the standardization and sensitivity of diagnostic tests for hepatitis B virus

2007 • 76 citations

A molecular analysis of viral persistence in surface antigen-negative chronic hepatitis B

1996 • 76 citations

The Oncogenic Potential of Hepatitis B virus rtA181T/ Surface Truncation Mutant

2008 • 75 citations

Hepatitis B Virus Pre-S2 Mutant Surface Antigen Induces Degradation of Cyclin-Dependent Kinase Inhibitor p27Kip1 through c-Jun Activation Domain-Binding Protein 1

2007 • 75 citations

The PreS2 Activators of the Hepatitis B Virus: Activators of Tumour Promoter Pathways

1998 • 74 citations

Clinical significance of pre‐S mutations in patients with genotype C hepatitis B virus infection

2006 • 74 citations

Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants

2010 • 72 citations

Roles of the Envelope Proteins in the Amplification of Covalently Closed Circular DNA and Completion of Synthesis of the Plus-Strand DNA in Hepatitis B Virus

2011 • 72 citations

Increased hepatocyte expression of hepatitis B virus transcription in patients with features of fibrosing cholestatic hepatitis

1993 • 71 citations

High level of genetic heterogeneity in S and P genes of genotype D hepatitis B virus

2007 • 69 citations

Aberrant cyclin A expression and centrosome overduplication induced by hepatitis B virus Pre-S2 mutants and its implication in hepatocarcinogenesis

2011 • 68 citations

Challenges in hepatitis B detection among blood donors

2011 • 65 citations

Increased Seroprevalence of HBV DNA With Mutations in the S Gene Among Individuals Greater Than 18 Years Old After Complete Vaccination

2012 • 65 citations

Characterization of essential domains for the functionality of the MHBst transcriptional activator and identification of a minimal MHBst activator.

1995 • 65 citations

Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein

2002 • 64 citations

Hepatitis B virus genetic diversity and its impact on diagnostic assays

2007 • 62 citations

Global control of hepatitis B virus: does treatment-induced antigenic change affect immunization?

2009 • 62 citations

Breakthrough of hepatitis B virus escape mutants after vaccination and virus reactivation

2006 • 61 citations

Viral apoptotic mimicry: an immune evasion strategy developed by the hepatitis B virus?

2003 • 60 citations

PreS and Core Gene Heterogeneity in Hepatitis B Virus (HBV) Genomes Isolated from Patients with Long-Lasting HBV Chronic Infection

1995 • 59 citations

A clustered ground‐glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery

2011 • 59 citations

Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic Hepatitis B virus infection

2004 • 59 citations

A molecular analysis of viral persistence in surface antigen-negative chronic hepatitis B

1996 • 58 citations

The Pre-S region determines the intracellular localization and appearance of hepatitis B virus

1999 • 56 citations

Hepatitis B virus sequence changes evolving in liver transplant recipients with fulminant hepatitis

1997 • 56 citations

Fibrosing cholestatic hepatitis: clinicopathologic spectrum, diagnosis and pathogenesis.

2008 • 56 citations

Identification of a Hepatitis B Virus S Gene Mutant in Lamivudine-Treated Patients Experiencing HBsAg Seroclearance

2006 • 54 citations

Development of HBV S gene mutants in chronic hepatitis B patients receiving nucleotide/nucleoside analogue therapy

2010 • 54 citations

Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERT

2009 • 54 citations

A unique insertion in the S gene of surface antigen?Negative hepatitis B virus chinese carriers

1995 • 54 citations

Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein

2002 • 53 citations

Acute liver injury following infection with a cytopathic strain of duck hepatitis B virus

1999 • 51 citations

Variability of reverse transcriptase and overlapping S gene in hepatitis B virus isolates from untreated and lamivudine-resistant chronic hepatitis B patients

2008 • 51 citations

Specific Amino Acid Substitutions in the S Protein Prevent Its Excretion In Vitro and May Contribute to Occult Hepatitis B Virus Infection

2013 • 49 citations

Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: Correlation with viral serotypes and clinical stages of liver disease

2002 • 45 citations

Hepatitis B envelope protein mutants in human hepatocellular carcinoma tissues

1999 • 43 citations

Analysis of viral proteins in circulating immune complexes from chronic carriers of hepatitis B virus.

1991 • 43 citations

Transmission of G145R mutant of HBV to an unrelated contact

2005 • 42 citations

Non-sequencing molecular approaches to identify preS2-defective hepatitis B virus variants proved to be associated with severe liver diseases

2003 • 42 citations

Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment

2012 • 39 citations

Histologic findings in recurrent HBV

2006 • 38 citations

Pre-S2 Deletions of Hepatitis B Virus and Hepatocellular Carcinoma in Children

2009 • 38 citations

Identification of nonsense mutations in hepatitis B virus S gene in patients with hepatocellular carcinoma developed after lamivudine therapy

2009 • 38 citations

Escape hepatitis B virus mutations in recipients of antibody to hepatitis B core antigen-positive liver grafts receiving hepatitis B immunoglobulins

2010 • 32 citations

Hepatic failure due to fibrosing cholestatic hepatitis in a patient with pre-surface mutant hepatitis B virus and mixed connective tissue disease treated with prednisolone and chloroquine

2004 • 29 citations

Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B

2013 • 28 citations

The hepatitis B virus protein MHBs(t) sensitizes hepatoma cells to TRAIL-induced apoptosis through ERK2

2007 • 27 citations

Variants of Hepatitis B Virus

1992 • 21 citations

Clinical course ofde novohepatitis B infection after pediatric liver transplantation

2010 • 21 citations

Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine

2004 • 21 citations

Hepatitis B caused by a hepatitis B surface antigen escape mutant

2008 • 20 citations

Revisiting the cytopathic effect of hepatitis B virus infection

2002 • 19 citations

Revisiting the cytopathic effect of hepatitis B virus infection

2002 • 16 citations

Hepatitis B antiviral resistance and vaccine escape: two sides of the same coin.

2008 • 16 citations

Hepatitis B defective virus with rearrangements in the preS gene during HBV chronic infection

1991 • 15 citations

Article Commentary: Hepatitis B Antiviral Resistance and Vaccine Escape: Two Sides of the Same Coin

2008 • 13 citations

Supportive Role Played by Precore and PreS2 Genomic Changes in the Establishment of Lamivudine‐Resistant Hepatitis B Virus

2008 • 13 citations