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Sorafenib in Advanced Hepatocellular Carcinoma

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Hepatocellular Carcinoma

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HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

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Chronic hepatitis B: Update 2009 #

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Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

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Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

2005 • 2,741 citations

The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide

2006 • 2,489 citations

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

2005 • 2,470 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

Hepatitis B Virus Infection — Natural History and Clinical Consequences

2004 • 2,271 citations

Complete Replication of Hepatitis C Virus in Cell Culture

2005 • 2,239 citations

Treatment of HCV Infection by Targeting MicroRNA

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Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

2012 • 1,885 citations

Universal Hepatitis B Vaccination in Taiwan and the Incidence of Hepatocellular Carcinoma in Children

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Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

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HBx gene of hepatitis B virus induces liver cancer in transgenic mice

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Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

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NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

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THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

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Epidemiology of Hepatocellular Carcinoma

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CD8⁺T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection

2002 • 913 citations

Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein

2002 • 894 citations

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

2012 • 850 citations

Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection

2007 • 847 citations

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

2012 • 822 citations

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

2012 • 809 citations

Eradication of Hepatitis C Virus Infection and the Development of Hepatocellular Carcinoma

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Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988–1994

2013 • 768 citations

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

2012 • 768 citations

Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma

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Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

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Ubiquitous Activation of Ras and Jak/Stat Pathways in Human HCC

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Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease

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Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B

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Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin

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Control of cccDNA function in hepatitis B virus infection

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Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

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Outcome of sustained virological responders with histologically advanced chronic hepatitis C

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HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

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Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

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Woodchuck hepatitis virus X protein is required for viral infection in vivo

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Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

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Hepatitis C Virus Core Protein Inhibits Mitochondrial Electron Transport and Increases Reactive Oxygen Species (ROS) Production

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Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication

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Immune Pathogenesis of Hepatocellular Carcinoma

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Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression

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Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: Incidence and survival in hepatitis C patients with advanced fibrosis

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Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis

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Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

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Hepatitis B virus X protein: a multifunctional viral regulator

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Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas

2005 • 313 citations

Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies

2007 • 310 citations

Mitochondrially Associated Hepatitis B Virus X Protein Constitutively Activates Transcription Factors STAT-3 and NF-κB via Oxidative Stress

2001 • 310 citations

Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene

2003 • 308 citations

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy

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Hepatitis B‐related hepatocellular carcinoma: epidemiological characteristics and disease burden

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Prospective Study of Hepatocellular Carcinoma and Liver Cirrhosis in Asymptomatic Chronic Hepatitis B Virus Carriers

1997 • 293 citations

A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease

2011 • 291 citations

Hepatitis B Virus X Protein Interferes with Cellular DNA Repair

1998 • 272 citations

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation

1995 • 250 citations

Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient*

2001 • 249 citations

Hepatitis C Virus NS5A Physically Associates with p53 and Regulates p21/waf1 Gene Expression in a p53-Dependent Manner

2001 • 248 citations

Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours

1990 • 245 citations

Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

1999 • 243 citations

Oncofetal GeneSALL4in Aggressive Hepatocellular Carcinoma

2013 • 238 citations

Serum Vascular Endothelial Growth Factor Predicts Venous Invasion in Hepatocellular Carcinoma : A Prospective Study

2001 • 237 citations

Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins

1996 • 237 citations

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

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Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

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New insight in the pathobiology of hepatitis B virus infection

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Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation

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Hepatitis B virus X protein is essential for the activation of Wnt/β-catenin signaling in hepatoma cells

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Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis

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Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer

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Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues.

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A Sustained Virological Response to Interferon or Interferon/Ribavirin Reduces Hepatocellular Carcinoma and Improves Survival in Chronic Hepatitis C: A Nationwide, Multicentre Study in Taiwan

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Cancer gene discovery in hepatocellular carcinoma

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The Hepatitis B Virus-X Protein Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade

2001 • 181 citations

Recurrent Targeted Genes of Hepatitis B Virus in the Liver Cancer Genomes Identified by a Next-Generation Sequencing–Based Approach

2012 • 181 citations

Expression of DNA Methyltransferase 1 Is Activated by Hepatitis B Virus X Protein via a Regulatory Circuit Involving the p16INK4a-Cyclin D1-CDK 4/6-pRb-E2F1 Pathway

2007 • 178 citations

Hepatitis B virus transgenic mice: Insights into the virus and the disease*1

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Hepatitis B virus X protein modulates oncogene yes-associated protein by CREB to promote growth of hepatoma cells

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Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model

2011 • 167 citations

Hepatic Iron Overload Induces Hepatocellular Carcinoma in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein

2006 • 166 citations

Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis

2012 • 164 citations

Hepatitis C Virus Seromarkers and Subsequent Risk of Hepatocellular Carcinoma: Long-Term Predictors From a Community-Based Cohort Study

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Hepatitis B Virus X Protein Stimulates Viral Genome Replication via a DDB1-Dependent Pathway Distinct from That Leading to Cell Death

2005 • 156 citations

HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice

2009 • 150 citations

The long and winding road leading to the identification of the hepatitis C virus

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Meta‐analysis: the impact of oral anti‐viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B

2013 • 146 citations

Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase

2005 • 142 citations

Hepatitis C Virus NS5A-Mediated Activation of Phosphoinositide 3-Kinase Results in Stabilization of Cellular β-Catenin and Stimulation of β-Catenin-Responsive Transcription

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Antibody to Hepatitis B Core Antigen and Risk for Hepatitis C–Related Hepatocellular Carcinoma

2007 • 136 citations

Hepatitis B Virus X Protein-Induced Aberrant Epigenetic Modifications Contributing to Human Hepatocellular Carcinoma Pathogenesis

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A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated With Risk for Hepatocellular Carcinoma

2011 • 136 citations

Long-term protection provided by hepatitis B vaccine and need for booster dose: A meta-analysis

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Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma

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Empirically Calibrated Model of Hepatitis C Virus Infection in the United States

2002 • 130 citations

Declining Incidence of Hepatocellular Carcinoma in Osaka, Japan, from 1990 to 2003

2008 • 128 citations

Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells

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Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/β-catenin signaling

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Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein

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Factors That Affect Risk for Hepatocellular Carcinoma and Effects of Surveillance

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The human liver-uPA-SCID mouse: A model for the evaluation of antiviral compounds against HBV and HCV

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Transcriptional repression of the human p53 gene by hepatitis B viral X protein

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Src kinases involved in hepatitis B virus replication

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Estrogen Represses Hepatocellular Carcinoma (HCC) Growth via Inhibiting Alternative Activation of Tumor-associated Macrophages (TAMs)

2012 • 116 citations

Hepatocellular carcinoma: insight from animal models

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Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

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Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam

2006 • 114 citations

Efficacy of tenofovir disoproxil fumarate at 240 weeks in patients with chronic hepatitis B with high baseline viral load

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Hepatitis B Viral RNA Directly Mediates Down-regulation of the Tumor Suppressor MicroRNA miR-15a/miR-16-1 in Hepatocytes

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Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1

2008 • 99 citations

Evidence for long-range oncogene activation by hepadnavirus insertion.

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Synergistic Effects of Family History of Hepatocellular Carcinoma and Hepatitis B Virus Infection on Risk for Incident Hepatocellular Carcinoma

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Functional Genomic Studies: Insights into the Pathogenesis of Liver Cancer

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Role of miR-148a in Hepatitis B Associated Hepatocellular Carcinoma

2012 • 95 citations

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation

2007 • 94 citations

Modulation of the Transforming Growth Factor-β Signal Transduction Pathway by Hepatitis C Virus Nonstructural 5A Protein

2006 • 94 citations

NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner

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MicroRNA-602 regulating tumor suppressive gene RASSF1A is over-expressed in hepatitis B virus-infected liver and hepatocellular carcinoma

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In vitro tumorigenicity of hepatitis B virus DNA and HBx protein

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Nonstructural 5A protein activates β-catenin signaling cascades: Implication of hepatitis C virus-induced liver pathogenesis

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Alteration of Intrahepatic Cytokine Expression and AP-1 Activation in Transgenic Mice Expressing Hepatitis C Virus Core Protein

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Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma

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Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

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Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-β pathway

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Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication

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Occult and previous hepatitis B virus infection are not associated with hepatocellular carcinoma in United States patients with chronic hepatitis C

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Targeted therapy of hepatocellular carcinoma: Present and future

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Hepatitis B virus X protein stimulates gene expression selectively from extrachromosomal DNA templates

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Cloning and analysis of integrated hepatitis virus sequences from a human hepatoma cell line

1984 • 75 citations

Association between vascular endothelial growth factor gene polymorphisms and survival in hepatocellular carcinoma patients†

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Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis

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New insights into HCV replication: potential antiviral targets.

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NF-κB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival

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Molecular biology of the hepatitis B virus and role of the X gene

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The DNA Damage Sensors Ataxia-Telangiectasia Mutated Kinase and Checkpoint Kinase 2 Are Required for Hepatitis C Virus RNA Replication

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Mechanisms of HCV-induced liver cancer: What did we learn from in vitro and animal studies?

2013 • 68 citations

Chronic liver inflammation and hepatocellular carcinoma: persistence matters

2011 • 66 citations

Hepatitis B Virus X Protein Associated with UV-DDB1 Induces Cell Death in the Nucleus and Is Functionally Antagonized by UV-DDB2

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Prospective Evaluation of Hepatitis B 1762T/1764A Mutations on Hepatocellular Carcinoma Development in Shanghai, China

2009 • 62 citations

Hepatic Expression of HCV RNA-Dependent RNA Polymerase Triggers Innate Immune Signaling and Cytokine Production

2012 • 60 citations

Hepatitis C virus NS5A protein interacts with -catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion

2009 • 58 citations

Proteomic Profiling Identifies Aberrant Epigenetic Modifications Induced by Hepatitis B Virus X Protein

2008 • 57 citations

Hepatitis B virus X protein induces hypermethylation of p16^INK4Apromoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis

2009 • 57 citations

Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice

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Hepatitis B virus X gene is implicated in liver carcinogenesis

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Zinc finger transcription factor 191, directly binding to β-catenin promoter, promotes cell proliferation of hepatocellular carcinoma

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Epidermal Growth Factor Gene Polymorphism and Risk of Hepatocellular Carcinoma: A Meta-Analysis

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Molecular evolutionary analyses implicate injection treatment for schistosomiasis in the initial hepatitis C epidemics in Japan

2004 • 52 citations

Serum aminotransferase level and the risk of hepatocellular carcinoma: a population-based cohort study in Japan

2008 • 50 citations

Hepatitis B Virus Inhibits Apoptosis of Hepatoma Cells by Sponging the MicroRNA 15a/16 Cluster

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Animal models for the study of HBV replication and its variants

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Incidence of hepatocellular carcinoma in hepatitis C carriers with normal alanine aminotransferase levels

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Republished: Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

2013 • 46 citations

Distinct hepatitis C virus core and F protein quasispecies in tumoral and nontumoral hepatocytes isolated via microdissection

2007 • 45 citations

HBV integrants of hepatocellular carcinoma cell lines contain an active enhancer

2001 • 42 citations

Altered Binding Site Selection of p53 Transcription Cassettes by Hepatitis B Virus X Protein

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Hepatitis C virus quasispecies in cancerous and noncancerous hepatic lesions: the core protein-encoding region.

2002 • 35 citations

Update in the management of chronic hepatitis B

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Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma

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Liver-specific Enhancer II Is the Target for the p53-mediated Inhibition of Hepatitis B Viral Gene Expression

1998 • 25 citations

Animal models in the study of hepatitis C virus-associated liver pathologies

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HCV Tumor Promoting Effect Is Dependent on Host Genetic Background

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Emerging Therapeutic Targets for Hepatitis C Virus Infection

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Epigenetic regulation of miR‐122 by PPARgammar and hepatitis B virus X protein in hepatocellular carcinoma cells

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Genotype 1a HCV (H77S) Infection System

2009 • 10 citations