Back to search

Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver

Data up to Jan 2025

Published2009
Citations71
References49

Total Citations Per Year

Abstract

References (49)

Global cancer statistics

2011 • 55,498 citations

Global Cancer Statistics, 2002

2005 • 17,966 citations

Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

2007 • 5,258 citations

Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors

2006 • 1,310 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Wnt signaling in disease and in development

2005 • 970 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin

2005 • 551 citations

Molecular viral oncology of hepatocellular carcinoma

2003 • 496 citations

The Enigmatic X Gene of Hepatitis B Virus

2004 • 486 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Dysregulation of growth factor signaling in human hepatocellular carcinoma

2006 • 387 citations

Genetics of hepatocellular carcinoma

2000 • 332 citations

Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma

2004 • 243 citations

Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

1997 • 228 citations

Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis

2006 • 226 citations

Hepatitis B virus X protein is essential for the activation of Wnt/β-catenin signaling in hepatoma cells

2004 • 206 citations

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

2008 • 201 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Effects of hepatitis B virus X protein on the development of liver cancer

2006 • 185 citations

An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis

2004 • 184 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

HBV induced carcinogenesis

2005 • 179 citations

Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells

2008 • 168 citations

Aspartyl-asparagyl β hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms

2006 • 156 citations

Oncogenic role of the frizzled-7/β-catenin pathway in hepatocellular carcinoma

2005 • 151 citations

Wnt/frizzled signaling in hepatocellular carcinoma

2006 • 150 citations

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma.

1996 • 142 citations

Molecular Profiling of Human Hepatocellular Carcinoma Defines Mutually Exclusive Interferon Regulation and Insulin-Like Growth Factor II Overexpression

2004 • 130 citations

Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor beta1-induced apoptosis.

1996 • 119 citations

Hepatitis B Virus X Protein Acts as a Tumor Promoter in Development of Diethylnitrosamine-Induced Preneoplastic Lesions

2001 • 117 citations

Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma

2006 • 115 citations

Beta‐catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E‐cadherin and accumulation of p53, but not with expression of conventional WNT‐1 target genes

2003 • 114 citations

Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation.

2000 • 114 citations

Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes

1997 • 104 citations

Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma

1994 • 101 citations

PIN1 overexpression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma

2004 • 99 citations

Overexpression of Human Insulin Receptor Substrate 1 Induces Cellular Transformation with Activation of Mitogen-Activated Protein Kinases

1996 • 88 citations

Neoplastic Transformation Induced by Insulin Receptor Substrate-1 Overexpression Requires an Interaction with Both Grb2 and Syp Signaling Molecules

1996 • 82 citations

Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) β-hydroxylase suppress migration of cholangiocarcinoma cells

2003 • 76 citations

Aspartyl-(asparaginyl)-β-hydroxylase regulates hepatocellular carcinoma invasiveness

2006 • 76 citations

A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype.

1996 • 73 citations

Expression of Hepatitis B Virus X Protein Does Not Alter the Accumulation of Spontaneous Mutations in Transgenic Mice

2000 • 54 citations

Clinicopathological correlates of aspartyl (asparaginyl) β-hydroxylase over-expression in cholangiocarcinoma

2004 • 50 citations

Increased expression of insulin-like growth factor 2 in hepatocellular carcinoma is primarily regulated at the transcriptional level.

1996 • 46 citations

Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein

2006 • 30 citations

Constitutive over-expression of the insulin receptor substrate-1 causes functional up-regulation of Fas receptor

2003 • 14 citations

Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only

2008 • 7 citations

Cited By (0)

No citing papers found in database

Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant… (2009) – Hepatology | Metascience Observatory Explorer