Polo-like Kinase 1 Activated by the Hepatitis B Virus X Protein Attenuates Both the DNA Damage Checkpoint and DNA Repair Resulting in Partial Polyploidy

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

2007 • 2,956 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Regulation of the G2/M transition by p53

2001 • 1,524 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

2001 • 1,036 citations

Gene Expression Patterns in Human Liver Cancers

2002 • 810 citations

BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo

2007 • 792 citations

Loss of a yeast telomere: Arrest, recovery, and chromosome loss

1993 • 787 citations

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

1998 • 773 citations

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

2004 • 724 citations

The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1

2007 • 664 citations

The impact of a negligent G2/M checkpoint on genomic instability and cancer induction

2007 • 574 citations

The Enigmatic X Gene of Hepatitis B Virus

2004 • 486 citations

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

1995 • 471 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

Polo-like kinase-1 is a target of the DNA damage checkpoint

2000 • 437 citations

CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint

1997 • 433 citations

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

2000 • 394 citations

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation

1997 • 392 citations

Polo-like kinases (Plks) and cancer

2005 • 380 citations

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

2008 • 374 citations

Polo-like Kinase-1 Controls Recovery from a G2 DNA Damage-Induced Arrest in Mammalian Cells

2004 • 361 citations

Polo-like kinases and oncogenesis

2005 • 360 citations

Plk1 promotes nuclear translocation of human Cdc25C during prophase

2002 • 318 citations

Normal Cells, but Not Cancer Cells, Survive Severe Plk1 Depletion

2006 • 300 citations

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

1997 • 286 citations

SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

2006 • 280 citations

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

2001 • 276 citations

Getting in and out of mitosis with Polo-like kinase-1

2005 • 268 citations

Polo-like Kinase 1 (Plk1) Inhibits p53 Function by Physical Interaction and Phosphorylation

2004 • 253 citations

Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress

2006 • 246 citations

Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk

1998 • 239 citations

Human Claspin Is Required for Replication Checkpoint Control

2003 • 232 citations

Adaptation of a DNA Replication Checkpoint Response Depends upon Inactivation of Claspin by the Polo-like Kinase

2004 • 220 citations

Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas

1998 • 219 citations

Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery

2006 • 217 citations

Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53

2004 • 193 citations

Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA

2002 • 183 citations

Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

1995 • 165 citations

Adaptation to the Ionizing Radiation–Induced G2 Checkpoint Occurs in Human Cells and Depends on Checkpoint Kinase 1 and Polo-like Kinase 1 Kinases

2006 • 159 citations

Inhibition of Polo-like Kinase-1 by DNA Damage Occurs in an ATM- or ATR-dependent Fashion

2001 • 157 citations

The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review).

1999 • 150 citations

A Role for Plk1 Phosphorylation of NudC in Cytokinesis

2003 • 146 citations

The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 Genes Are Required for Tolerating Irreparable, Ultraviolet-Induced DNA Damage

1998 • 133 citations

Rad17 Phosphorylation Is Required for Claspin Recruitment and Chk1 Activation in Response to Replication Stress

2006 • 130 citations

Probing cell-division phenotype space and Polo-like kinase function using small molecules

2006 • 122 citations

Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas

2004 • 118 citations

Hepatitis B Virus X Protein Acts as a Tumor Promoter in Development of Diethylnitrosamine-Induced Preneoplastic Lesions

2001 • 117 citations

Pifithrin-α Inhibits p53 Signaling after Interaction of the Tumor Suppressor Protein with hsp90 and Its Nuclear Translocation

2004 • 106 citations

Plk1-dependent Phosphorylation Regulates Functions of DNA Topoisomerase IIα in Cell Cycle Progression

2008 • 95 citations

Polo‐like kinase 1 phosphorylation of G2 and S‐phase‐expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery

2010 • 94 citations

Human Papillomavirus 16 E7 Oncoprotein Attenuates DNA Damage Checkpoint Control by Increasing the Proteolytic Turnover of Claspin

2009 • 92 citations

Hepatitis B Virus X Protein Differentially Activates RAS-RAF-MAPK and JNK Pathways in X-transforming Versus Non-transforming AML12 Hepatocytes

2001 • 90 citations

Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing

2008 • 89 citations

Sustained Activation of p38 Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase Pathways by Hepatitis B Virus X Protein Mediates Apoptosis via Induction of Fas/FasL and Tumor Necrosis Factor (TNF) Receptor 1/TNF-α Expression

2004 • 89 citations

Plk1-mediated Phosphorylation of Topors Regulates p53 Stability

2009 • 84 citations

Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis

2008 • 80 citations

Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6

2005 • 78 citations

Hepatitis B Virus X Protein Differentially Regulates Cell Cycle Progression in X-transforming Versus Nontransforming Hepatocyte (AML12) Cell Lines

2002 • 73 citations

Differential Immediate Early Gene Expression in Conditional Hepatitis B Virus pX-transforming VersusNontransforming Hepatocyte Cell Lines

1999 • 69 citations

Checkpoint adaptation in human cells

2007 • 67 citations

A Functional Role for p38 MAPK in Modulating Mitotic Transit in the Absence of Stress

2007 • 64 citations

Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes

2002 • 60 citations

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage

2005 • 56 citations

Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression

2008 • 52 citations

Hepatitis B Virus X Protein Increases the Cdt1-to-Geminin Ratio Inducing DNA Re-replication and Polyploidy

2008 • 50 citations

Plk1 Phosphorylation of TRF1 Is Essential for Its Binding to Telomeres

2008 • 45 citations

Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression

2009 • 42 citations

Papillomavirus type 16 E6/E7 and human telomerase reverse transcriptase in esophageal cell immortalization and early transformation

2006 • 31 citations

Polo‐like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation

2006 • 28 citations

Cdc2-mediated Phosphorylation of CLIP-170 Is Essential for Its Inhibition of Centrosome Reduplication

2009 • 26 citations

More is less

2007 • 3 citations