Back to search

A molecular chaperone complex at the lysosomal membrane is required for protein translocation

Data up to Jan 2025

Published2001
Citations362
References60

Total Citations Per Year

Abstract

References (60)

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

1996 • 904 citations

Identification of CHIP, a Novel Tetratricopeptide Repeat-Containing Protein That Interacts with Heat Shock Proteins and Negatively Regulates Chaperone Functions

1999 • 904 citations

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1990 • 674 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

[16] Isolation of subcellular organelles

1990 • 563 citations

Autophagy and related mechanisms of lysosome-mediated protein degradation

1994 • 506 citations

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1996 • 460 citations

Hip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle

1995 • 436 citations

Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.

1985 • 365 citations

Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation

1995 • 322 citations

An Intralysosomal hsp70 Is Required for a Selective Pathway of Lysosomal Protein Degradation

1997 • 299 citations

Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin

1994 • 297 citations

Chaperones get in touch: the Hip-Hop connection

1997 • 289 citations

Unique properties of lamp2a compared to other lamp2 isoforms

2000 • 289 citations

A Population of Rat Liver Lysosomes Responsible for the Selective Uptake and Degradation of Cytosolic Proteins

1997 • 283 citations

The Carboxy-Terminal Domain of Hsc70 Provides Binding Sites for a Distinct Set of Chaperone Cofactors

1998 • 269 citations

The Assembly of Progesterone Receptor-hsp90 Complexes Using Purified Proteins

1998 • 239 citations

Protein translocation into mitochondria: the role of TIM complexes

2000 • 226 citations

Import of a Cytosolic Protein into Lysosomes by Chaperone-Mediated Autophagy depends on its Folding State

2000 • 204 citations

Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein.

1992 • 201 citations

Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins.

1987 • 197 citations

Import of a Cytosolic Protein into Lysosomes by Chaperone-mediated Autophagy Depends on Its Folding State

2000 • 180 citations

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release

1998 • 179 citations

Protein transport into mitochondria

2000 • 158 citations

The Mammalian Calcium-binding Protein, Nucleobindin (CALNUC), Is a Golgi Resident Protein

1998 • 154 citations

Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats

1991 • 152 citations

ATP-dependent chaperoning activity of reticulocyte lysate

1994 • 143 citations

Bag1 Functions In Vivo as a Negative Regulator of Hsp70 Chaperone Activity

2000 • 137 citations

Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes

1994 • 134 citations

Structural Features Required for the Interaction of the Hsp70 Molecular Chaperone DnaK with Its Cochaperone DnaJ

1999 • 127 citations

Isolation and Characterization of Pas2p, a Peroxisomal Membrane Protein Essential for Peroxisome Biogenesis in the Methylotrophic Yeast Pichia pastoris

1996 • 125 citations

Degradation of proteins microinjected into IMR-90 human diploid fibroblasts.

1981 • 121 citations

Human DnaJ Homologs dj2 and dj3, and bag-1 Are Positive Cochaperones of hsc70

2000 • 121 citations

Polypeptide import and degradation by isolated lysosomes.

1993 • 103 citations

Characterization of Interactions between the Anti-apoptotic Protein BAG-1 and Hsc70 Molecular Chaperones

1998 • 103 citations

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper

2001 • 100 citations

Regulation of intracellular protein degradation in IMR‐90 human diploid fibroblasts

1983 • 99 citations

A family of ubiquitin‐like proteins binds the ATPase domain of Hsp70‐like Stch

2000 • 91 citations

Distinct Isoforms of the Cofactor BAG-1 Differentially Affect Hsc70 Chaperone Function

2000 • 85 citations

Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids.

1983 • 81 citations

Maturation of steroid receptors: an example of functional cooperation among molecular chaperones and their associated proteins

2000 • 79 citations

The Early Stage of Chloroplast Protein Import Involves Com70

1997 • 74 citations

Lysosomal Pathways of Protein Degradation

2000 • 69 citations

Membrane association of cytochrome b6f subunits. The Rieske iron-sulfur protein from Chlamydomonas reinhardtii is an extrinsic protein.

1994 • 69 citations

Membrane deinsertion of SecA underlying proton motive force-dependent stimulation of protein translocation

1999 • 67 citations

A Rapid and Simplified Method for the Preparation of Lysosomal Membranes from Rat Liver<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1983 • 64 citations

Purification and Characterization of a 66-kDa Protein from Rabbit Reticulocyte Lysate Which Promotes the Recycling of Hsp 70

1996 • 54 citations

Oxa1p, which is required for cytochrome c oxidase and ATP synthase complex formation, is embedded in the mitochondrial inner membrane

1997 • 51 citations

The biogenesis and assembly of bacterial membrane proteins

2000 • 46 citations

Solubilization and characterization of yeast signal peptidase

1989 • 45 citations

How to get a folded protein across a membrane

1999 • 45 citations

Translocation of Proteins across the Endoplasmic Reticulum Membrane

1997 • 44 citations

Import into and Degradation of Cytosolic Proteins by Isolated Yeast Vacuoles

1999 • 34 citations

Interaction between Hsc70 and DnaJ Homologues: Relationship between Hsc70 Polymerization and ATPase Activity

1999 • 21 citations

Purification of a 38-kDa Protein from Rabbit Reticulocyte Lysate Which Promotes Protein Renaturation by Heat Shock Protein 70 and Its Identification as δ-Aminolevulinic Acid Dehydratase and as a Putative DnaJ Protein

1999 • 11 citations

Mammalian Hsc70, Hsp70 proteins

1997 • 1 citations

Cited By (0)

Loading...
A molecular chaperone complex at the lysosomal membrane is required for protein… (2001) – Journal of Cell Science | Metascience Observatory Explorer