Lysosomal enzyme secretory mutants of Dictyostelium discoideum

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

1980 • 743 citations

The Development of Dictyostelium Discoideum

1982 • 664 citations

Role of carbohydrates in protein secretion and turnover: Effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts

1978 • 391 citations

Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity.

1981 • 323 citations

Suppression of glycoprotein formation of Semliki Forest, influenza, and avian sarcoma virus by tunicamycin

1976 • 254 citations

Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting.

1983 • 186 citations

Acetylglucosaminidase, an Early Enzyme in the Development of Dictyostelium discoideum

1969 • 122 citations

Structural analysis of the asparagine-linked oligosaccharides from three lysosomal enzymes of Dictyostelium discoideum. Evidence for an unusual acid-stable phosphodiester.

1983 • 111 citations

Developmental Regulation of α-Mannosidase in Dictyostelium discoideum

1970 • 109 citations

Secretion of Lysosomal enzymes in the cellular slime mold, Dictyostelium discoideum.

1981 • 109 citations

Protozoan Parasite of Humans: Surface Membrane with Externally Disposed Acid Phosphatase

1981 • 108 citations

Isolation of mutations in Dictyostelium discoideum affecting α-mannosidase

1975 • 95 citations

Identification of methylphosphomannosyl residues as components of the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins.

1984 • 93 citations

Structural analysis of N-linked oligosaccharides from glycoproteins secreted by Dictyostelium discoideum. Identification of mannose 6-sulfate.

1986 • 90 citations

Influence of the heterosaccharides in porcine pancreatic ribonuclease on the conformation and stability of the protein

1977 • 89 citations

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

1986 • 85 citations

Antigenic determinants shared by lysosomal proteins of Dictyostelium discoideum. Characterization using monoclonal antibodies and isolation of mutations affecting the determinant.

1984 • 79 citations

Enzyme synthesis in myxamoebae of the cellular slime mould Dictyostelium discoideum during growth in axenic culture

1972 • 79 citations

Pathways involved in targeting and secretion of a lysosomal enzyme in Dictyostelium discoideum.

1985 • 70 citations

Structure and function of beta-blucosidases in Dictyostelium discoideum.

1976 • 62 citations

The mannose 6-phosphate receptor of Chinese hamster ovary cells. Compartmentalization of acid hydrolases in mutants with altered receptors.

1981 • 61 citations

Synthesis of related forms of the lysosomal enzyme alpha-mannosidase in Dictyostelium discoideum.

1983 • 61 citations

Isolation and characterization of mutations affecting UDPG pyrophosphorylase activity in Dictyostelium discoideum

1976 • 55 citations

Regulation and secretion of early developmentally controlled enzymes during axenic growth in Dictyostelium discoideum

1981 • 54 citations

Lysosomal enzymes in Dictyostelium discoideum are transported to lysosomes at distinctly different rates.

1986 • 47 citations

Hydrolase secretion is a consequence of membrane recycling.

1984 • 46 citations

The mod A mutant of Dictyostelium discoideum is missing the alpha 1,3-glucosidase involved in asparagine-linked oligosaccharide processing.

1983 • 44 citations

The high mannose oligosaccharides of Dictyostelium discoideum glycoproteins contain a novel intersecting N-acetylglucosamine residue.

1987 • 44 citations

Isolation and characterization of a mutant of Tetrahymena thermophila blocked in secretion of lysosomal enzymes

1987 • 43 citations

Mod A: A post-translational mutation affecting phosphorylated and sulfated glycopeptides in Dictyostelium discoideum

1981 • 40 citations

Mannose-receptor ligands stimulate secretion of lysosomal enzymes from rabbit alveolar macrophages.

1987 • 36 citations

Transit of alpha-mannosidase during its maturation in Dictyostelium discoideum.

1985 • 35 citations

Chapter 7 Defining the Intracellular Localization Pathways followed by Lysosomal Enzymes in Dictyostelium discoideum

1987 • 35 citations

[65] Secretory mutants in the cellular slime mold Dictyostelium discoideum

1983 • 34 citations

Protease secretion during onset of development in Dictyostelium discoideum

1978 • 30 citations

Processing, transport, and secretion of the lysosomal enzyme acid phosphatase in Dictyostelium discoideum

1989 • 30 citations

Secretion heterogeneity of lysosomal enzymes in Tetrahymena pyriformis

1987 • 29 citations

Developmental changes in the modification of lysosomal enzymes in Dictyostelium discoideum

1985 • 25 citations

Initial events involved in the synthesis of the lysosomal enzyme α-mannosidase in Dictyostelium discoideum

1986 • 24 citations

A Dictyostelium discoideum mutant that missorts and oversecretes lysosomal enzyme precursors is defective in endocytosis.

1989 • 22 citations

Effects of Sugars on Glycosidase Secretion in Dictyostelium discoideum

1979 • 21 citations

Lysosomes in Tetrahymena.

1975 • 14 citations

Biosynthesis of secreted β-hexosaminidase in Tetrahymena thermophila. A comparison of the wild type with a secretory mutant

1988 • 14 citations

Biogenesis of lysosomal enzymes in the α-glucosidase II-deficient modA mutant of Dictyostelium discoideum: Retention of α-1,3-linked glucose on N-linked oligosaccharides delays intracellular transport but does not alter sorting of α-mannosidase or β-glucosidase

1989 • 13 citations

Developments in cell biology: secretory processes

1986 • 13 citations

Characterization and distribution of multiple antigens on N-linked oligosaccharides of Dictyostelium discoideum proteins

1987 • 13 citations

Examination of isoelectric focusing and electrophoretic methods for resolving acidic proteins

1986 • 1 citations