The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?

The Metabolic Basis of Inherited Diseases

1972 • 1,762 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage.

1981 • 990 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

1994 • 676 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Rab 7: an important regulator of late endocytic membrane traffic.

1995 • 625 citations

Implications of the SNARE hypothesis for intracellular membrane topology and dynamics

1994 • 582 citations

Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation

1985 • 448 citations

THE INTERACTION OF SOLUBLE HORSERADISH PEROXIDASE WITH MOUSE PERITONEAL MACROPHAGES IN VITRO

1972 • 431 citations

Endosomes

1983 • 416 citations

Rab GTPases in vesicular transport

1993 • 379 citations

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes.

1996 • 357 citations

Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

1995 • 331 citations

Targeting of membrane proteins to endosomes and lysosomes

1994 • 304 citations

The rab7 gtpase resides on a vesicular compartment connected to lysosomes

1995 • 297 citations

Cytoplasmic coat proteins involved in endosome function

1995 • 290 citations

Molecular characterization of phagosomes.

1994 • 287 citations

The small GTP-binding protein rab4 is associated with early endosomes.

1991 • 286 citations

Blueprint for a cell: the nature and origin of life

1991 • 286 citations

Biogenesis of phagolysosomes: the 'kiss and run' hypothesis

1995 • 252 citations

Cycling of the integral membrane glycoprotein, LEP100, between plasma membrane and lysosomes: Kinetic and morphological analysis

1987 • 244 citations

Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport.

1995 • 230 citations

The discovery of lysosomes.

1981 • 223 citations

Exocytosis of pinocytosed fluid in cultured cells: kinetic evidence for rapid turnover and compartmentation.

1981 • 215 citations

Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins.

1987 • 197 citations

Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes.

1990 • 185 citations

Receptor-Mediated Protein Sorting to the Vacuole in Yeast: Roles for a Protein Kinase, a Lipid Kinase and GTP-Binding Proteins

1995 • 184 citations

Involvement of microtubule motors in basolateral and apical transport in kidney cells

1994 • 183 citations

Selective recycling of the mannose 6-phosphate/IGF-II receptor to the trans Golgi network in vitro

1988 • 177 citations

A Casein Kinase II Phosphorylation Site in the Cytoplasmic Domain of the Cation-dependent Mannose 6-Phosphate Receptor Determines the High Affinity Interaction of the AP-1 Golgi Assembly Proteins with Membranes

1996 • 173 citations

Maturation models for endosome and lysosome biogenesis

1991 • 172 citations

The motif Tyr-X-X-hydrophobic residue mediates lysosomal membrane targeting of lysosome-associated membrane protein 1.

1993 • 169 citations

The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes

1994 • 145 citations

Targeting signals and subunit interactions in coated vesicle adaptor complexes.

1995 • 145 citations

Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts.

1993 • 144 citations

The giant organelles in beige and Chediak-Higashi fibroblasts are derived from late endosomes and mature lysosomes.

1993 • 131 citations

Molecular size-fractionation during endocytosis in macrophages.

1995 • 130 citations

The fusion pore and mechanisms of biological membrane fusion

1996 • 120 citations

Evidence for retrograde traffic between terminal lysosomes and the prelysosomal/late endosome compartment

1994 • 117 citations

Principles of Medical Biology

1997 • 109 citations

Plasticity of the tubular lysosomal compartment in macrophages

1990 • 103 citations

Biogenesis of lysosomal membranes

1994 • 101 citations

Re-expression of the Mannose 6-Phosphate Receptors in Receptor-deficient Fibroblasts

1996 • 83 citations

Evidence for both prelysosomal and lysosomal intermediates in endocytic pathways.

1984 • 81 citations

A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes.

1995 • 79 citations

Roles for mannose-6-phosphate receptors in lysosomal enzyme sorting, IGF-II binding and clathrin-coat assembly

1995 • 77 citations

The morphology but not the function of endosomes and lysosomes is altered by brefeldin A.

1992 • 77 citations

Differential and sequential delivery of fluorescent lysosomal probes into phagosomes in mouse peritoneal macrophages.

1987 • 69 citations

Biogenesis of phagolysosomes: the ‘kiss and run’ hypothesis

1995 • 67 citations

Animal cell lysosomes rapidly exchange membrane proteins.

1988 • 59 citations

Osmotic swelling of endocytic compartments induced by internalized sucrose is restricted to mature lysosomes in cultured mammalian cells

1991 • 49 citations

The lysosomal proenzyme receptor that binds procathepsin L to microsomal membranes at pH 5 is a 43-kDa integral membrane protein.

1993 • 49 citations

Enigma variations: Protein mediators of membrane fusion

1995 • 46 citations

Complementation analysis of Chediak-Higashi Syndrome: The same gene may be responsible for the defect in all patients and species

1993 • 35 citations

Assembly of Lysosomes: Perspectives from Comparative Molecular Cell Biology

1988 • 35 citations

Comparative behavior of lysosomes and the pre-lysosome compartment (PLC) in in vivo cell fusion experiments

1991 • 35 citations

Chediak-higashi syndrome is not due to a defect in microtubule-based lysosomal mobility

1993 • 32 citations

Membrane fusion in organelle biogenesis

1996 • 31 citations

Retention of pinocytized solute by cho cell lysosomes correlates with molecular weight

1987 • 27 citations

Roles for mannose-6-phosphate receptors in lysosomal enzyme sorting, IGF-II binding and clathrin-coat assembly

1995 • 23 citations

Lysosomal integral membrane glycoproteins are expressed at high levels in the inclusion bodies of I-cell disease fibroblasts

1989 • 18 citations

Effects of pH, detergent and salt on aggregation of Chinese-hamster-ovary-cell lysosomal enzymes

1988 • 16 citations

Chinese Hamster Ovary Cell Lysosomes Retain Pinocytized Horseradish Peroxidase and In Situ-Radioiodinated Proteins

1984 • 10 citations

Small GTP-Binding Proteins on Rat Liver Lysosomal Membranes.

1992 • 7 citations

Protein Exchange Within the Lysosome and Pre-Lysosome Compartment: A Mechanism for Maintaining Organelle Functionality?

1992 • 2 citations