A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Uncoating ATPase is a member of the 70 kilodalton family of stress proteins

1986 • 607 citations

Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells.

1984 • 522 citations

Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous.

1984 • 513 citations

Complex Interactions Among Members of an Essential Subfamily of hsp70 Genes in Saccharomyces Cerevisiae

1987 • 358 citations

Expression of human HSP70 during the synthetic phase of the cell cycle.

1986 • 316 citations

Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions

1980 • 286 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

Complex regulation of heat shock- and glucose-responsive genes in human cells.

1988 • 242 citations

Peptide sequences that target proteins for enhanced degradation during serum withdrawal.

1988 • 238 citations

Developmental control of the heat shock response in Xenopus.

1984 • 195 citations

Saccharomyces cerevisiae contains a complex multigene family related to the major heat shock-inducible gene of Drosophila.

1982 • 177 citations

Constitutively Expressed Rat mRNA Encoding a 70-Kilodalton Heat-Shock-Like Protein

1985 • 164 citations

Organization, nucleotide sequence, and transcription of the chicken HSP70 gene.

1986 • 122 citations

Degradation of proteins microinjected into IMR-90 human diploid fibroblasts.

1981 • 121 citations

Regulation of catabolism of microinjected ribonuclease A. Identification of residues 7-11 as the essential pentapeptide.

1986 • 117 citations

Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids.

1983 • 81 citations

Proteins related to the mouse L-cell major heat shock protein are synthesized in the absence of heat shock gene expression.

1984 • 75 citations

Differential regulation of the 70K heat shock gene and related genes in Saccharomyces cerevisiae.

1984 • 67 citations

Lysosomal degradation of ribonuclease A and ribonuclease S-protein microinjected into the cytosol of human fibroblasts.

1985 • 65 citations

70-Kilodalton Heat Shock Polypeptides from Rainbow Trout: Characterization of cDNA Sequences

1984 • 58 citations

Artifacts associated with 2-mercaptoethanol upon high resolution two-dimensional electrophoresis

1984 • 53 citations

78-Kilodalton Glucose-Regulated Protein Is Induced in Rous Sarcoma Virus-Transformed Cells Independently of Glucose Deprivation

1988 • 45 citations

Intracellular distribution of mammalian stress proteins. Effects of cytoskeletal-specific agents.

1987 • 45 citations

The 73 kilodalton heat shock cognate protein purified from rat brain contains nonesterified palmitic and stearic acids

1986 • 41 citations

Peptide signals for protein degradation within lysosomes.

1989 • 35 citations

Degradation of endocytosed proteins is unaltered in senescent human fibroblasts

1988 • 17 citations

Purification and characterization of lysosomes from Chinese hamster ovary cells

1987 • 16 citations

Spontaneous fragmentation of several proteins in Drosophila pupae.

1987 • 6 citations

An ATP-dependent system specific for degradation of long-lived proteins in permeabilized cells

1988 • 3 citations