Lytic granules from cytotoxic T cells exhibit kinesin-dependent motility on microtubules in vitro

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

1985 • 1,930 citations

Forces of a single-beam gradient laser trap on a dielectric sphere in the ray optics regime

1992 • 1,623 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

A novel brain ATPase with properties expected for the fast axonal transport motor

1985 • 604 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts

1978 • 547 citations

Retrograde transport by the microtubule-associated protein MAP 1C

1987 • 547 citations

Translocation and clustering of endosomes and lysosomes depends on microtubules.

1987 • 498 citations

Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein.

1991 • 482 citations

Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro

1985 • 463 citations

Video‐enhanced contrast, differential interference contrast (AVEC‐DIC) microscopy: A new method capable of analyzing microtubule‐related motility in the reticulopodial network of allogromia laticollaris

1981 • 419 citations

[36] Preparation of tubulin from brain

1982 • 395 citations

Intracellular Transport Using Microtubule-Based Motors

1987 • 356 citations

The movement of membranous organelles in axons. Electron microscopic identification of anterogradely and retrogradely transported organelles.

1980 • 349 citations

Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon

1985 • 346 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

Two activators of microtubule-based vesicle transport.

1991 • 325 citations

A novel serine esterase expressed by cytotoxic T lymphocytes

1985 • 319 citations

Cytoplasmic dynein is a minus end-directed motor for membranous organelles

1989 • 313 citations

Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells

1990 • 299 citations

Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets.

1983 • 294 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

Radial extension of macrophage tubular lysosomes supported by kinesin

1990 • 276 citations

Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules.

1987 • 270 citations

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

1989 • 258 citations

Role of microtubules in polarized delivery of apical membrane proteins to the brush border of the intestinal epithelium.

1989 • 240 citations

Rotation and translocation of microtubules in vitro induced by dyneins from Tetrahymena cilia

1988 • 237 citations

Microtubules, membrane traffic, and cell organization

1990 • 229 citations

Reclustering of scattered Golgi elements occurs along microtubules.

1989 • 228 citations

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors.

1984 • 219 citations

Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans

1987 • 218 citations

Bovine brain kinesin is a microtubule-activated ATPase.

1986 • 215 citations

Microtubule-acting drugs lead to the nonpolarized delivery of the influenza hemagglutinin to the cell surface of polarized Madin-Darby canine kidney cells.

1987 • 210 citations

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1989 • 186 citations

Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP

1985 • 184 citations

Inhibition of kinesin-driven microtubule motility by monoclonal antibodies to kinesin heavy chains.

1988 • 180 citations

The role of kinesin and other soluble factors in organelle movement along microtubules.

1988 • 179 citations

Nocodazole, a microtubule-active drug, interferes with apical protein delivery in cultured intestinal epithelial cells (Caco-2).

1989 • 176 citations

Role of microtubules in the organisation of the Golgi apparatus

1990 • 171 citations

Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.

1986 • 166 citations

The short term accumulation of axonally transported organelles in the region of localized lesions of single myelinated axons

1980 • 163 citations

Steady-state distribution and biogenesis of endogenous Madin-Darby canine kidney glycoproteins: evidence for intracellular sorting and polarized cell surface delivery.

1989 • 155 citations

Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro

1980 • 155 citations

Characterization of the microtubule movement produced by sea urchin egg kinesin.

1987 • 153 citations

The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments.

1990 • 152 citations

Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.

1985 • 137 citations

Ultrastructure of human natural killer cells: nature of the cytolytic contacts in relation to cellular secretion.

1982 • 132 citations

Photosensitized cleavage of dynein heavy chains. Cleavage at the V2 site by irradiation at 365 NM in the presence of oligovanadate.

1987 • 132 citations

Photosensitized cleavage of dynein heavy chains. Cleavage at the “V1 site” by irradiation at 365 nm in the presence of ATP and vanadate.

1987 • 131 citations

Purified kinesin promotes vesicle motility and induces active sliding between microtubules in vitro.

1991 • 124 citations

The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells.

1985 • 106 citations

Binding of pp170 to microtubules is regulated by phosphorylation.

1991 • 101 citations

Kinesin is bound with high affinity to squid axon organelles that move to the plus-end of microtubules.

1992 • 95 citations

Mechanisms of human cell-mediated cytotoxicity. III. Dependence of natural killing on microtubule and microfilament integrity.

1982 • 94 citations

The mechanism and regulation of fast axonal transport

1989 • 90 citations

Chapter 23 Preparation and Purification of Dynein

1982 • 82 citations

Target-effector cell interaction in the natural killer cell system. V. Energy requirements, membrane integrity, and the possible involvement of lysosomal enzymes.

1980 • 82 citations

A model for kinesin movement from nanometer-level movements of kinesin and cytoplasmic dynein and force measurements

1991 • 51 citations

Direct Analysis of Individual Killer T Cells: Susceptibility of Target Cells to Lysis and Secretion of Hydrolytic Enzymes by CTL

1982 • 51 citations

Secretory granules and endosomes show saltatory movement biased to the anterograde and retrograde directions, respectively, along microtubules in AtT20 cells.

1989 • 47 citations

Cultured cell extracts support organelle movement on microtubules in vitro

1988 • 47 citations

Differential requirements for the induction of interleukin 2 responsiveness in L3T4+ and Lyt-2+ T cell subsets.

1985 • 45 citations

Identification of a lysosome membrane protein which could mediate ATP-dependent stable association of lysosomes to microtubules

1989 • 40 citations

Three intracellular signals for cytotoxic T lymphocyte-mediated killing. Independent roles for protein kinase C, Ca2+ influx, and Ca2+ release from internal stores.

1991 • 39 citations

Signal requirements for the in vitro differentiation of cytotoxic T lymphocytes (CTL): distinct soluble mediators promote preactivation of CTL‐precursors, clonal growth and differentiation into cytotoxic effector cells

1985 • 39 citations

Electron microscopic study of natural killer cell-tumor cell conjugates

1982 • 34 citations

Inhibition of NK and ADCC Activity by Antibodies Against Purified Cytoplasmic Granules From Rat LGL Tumors

1987 • 28 citations

Cell-mediated cytotoxicity and the reorientation of effector cell granules towards the target cell are inhibited by the protonophore carbonylcyanide m-chlorophenylhydrazone

1988 • 7 citations