Identification and mutation analysis of the complete gene for Chediak–Higashi syndrome

Predicting Coiled Coils from Protein Sequences

1991 • 3,977 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

Issues in searching molecular sequence databases

1994 • 781 citations

[33] Analysis of compositionally biased regions in sequence databases

1996 • 768 citations

Crystal structure of a GA protein βγdimer at 2.1 Å resolution

1996 • 741 citations

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1995 • 736 citations

Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules

1996 • 651 citations

PHD-an automatic mail server for protein secondary structure prediction

1994 • 561 citations

Identification of the homologous beige and Chediak–Higashi syndrome genes

1996 • 536 citations

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.

1993 • 340 citations

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

1995 • 298 citations

.alpha.- And .beta.-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

1990 • 236 citations

Congenital Gigantism of Peroxidase Granules

1954 • 217 citations

Identification of the murine beige gene by YAC complementation and positional cloning

1996 • 193 citations

Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice.

1975 • 173 citations

Giant Granules in Leukocytes of the Beige Mouse

1967 • 170 citations

[11] Applying motif and profile searches

1996 • 159 citations

Protein sequence motifs

1996 • 156 citations

Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci

1984 • 141 citations

The giant organelles in beige and Chediak-Higashi fibroblasts are derived from late endosomes and mature lysosomes.

1993 • 131 citations

A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery.

1991 • 107 citations

Genetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43.

1996 • 91 citations

On the analysis of the pathophysiology of Chediak-Higashi syndrome. Defects expressed by cultured melanocytes.

1994 • 81 citations

A new class of lysosomal/vacuolar protein sorting signals.

1990 • 77 citations

Homozygosity mapping of the gene for Chediak-Higashi syndrome to chromosome 1q42-q44 in a segment of conserved synteny that includes the mouse beige locus (bg).

1996 • 57 citations

Chediak-Higashi lymphoblastoid cell lines: Granule characteristics and expression of lysosome-associated membrane proteins

1992 • 32 citations

The origin and fate of large dense bodies in beige mouse fibroblasts

1981 • 22 citations

Turnover of kidney beta-glucuronidase in normal and Chédiak-Higashi (beige) mice.

1978 • 22 citations

A comparative study of the lesions in cultured fibroblasts of humans and four species of animals with Chediak‐Higashi syndrome

1987 • 19 citations

Lysosomal enzyme activities in Chediak-Higashi syndrome: evaluation of lymphoblastoid cell lines and review of the literature.

1994 • 17 citations